Results 91 to 100 of about 230,259 (343)
Angewandte Chemie, EarlyView.ROXendin668 is a peptidic GLP‐1 receptor agonist that generates toxic singlet oxygen upon irradiation with far‐red light. Pancreatic beta cells can be photo‐ablated in a spatiotemporally controlled manner. This approach has the potential to provide a safer alternative to streptozotocin or alloxan for creating model systems for type 1 diabetes research.
Kilian Roßmann +17 more
wiley +2 more sources
ToxicsPolycyclic aromatic hydrocarbons (PAHs) are ubiquitous combustion-derived contaminants that represent a significant cross-cutting threat to human, animal, and environmental health.
Jose L. Domingo +2 more
doaj +1 more source
Smart Bioinks for 4D Bioprinting: Requirements, Design, and Applications
Advanced Science, EarlyView.Smart bioinks empower 4D‐bioprinted constructs to dynamically adapt and remodel in response to stimuli, effectively biomimicking native tissues. Artificial Intelligence (AI) and Machine Learning (ML) play a guiding role in their rational design by optimizing relevant properties.
Shangsi Chen +11 more
wiley +1 more source
Functionalization and Metal Ion Encapsulation Within a Triaxial Supramolecular Weave
Angewandte Chemie, EarlyView.The functionalization of a triaxially woven supramolecular weave was achieved. Pre‐assembly modification of the peptide‐perylene monoimide building block enabled facile and homogeneous introduction of acetyl, pivaloyl and thiophene moieties throughout the assembly without disrupting the woven structure.
Andreas Herdlitschka +6 more
wiley +2 more sources
Вавиловский журнал генетики и селекции, 2016 Various mutationally impaired genes are often found in malignant tumors of animals and humans. At the same time, a large number of carcinogens demonstrate positive activity in different in vitro tests for mutagenicity.
V. I. Kaledin +4 more
doaj +1 more source
Sucralose Non-Carcinogenicity: A Review of the Scientific and Regulatory Rationale
Nutrition and Cancer, 2016 Regulatory authorities worldwide have found the nonnutritive sweetener, sucralose, to be noncarcinogenic, based on a range of studies. A review of these and other studies found through a comprehensive search of electronic databases, using appropriate key
C. Berry +5 more
semanticscholar +1 more source
Assessing compound carcinogenicity in vitro using connectivity mapping
, 2014 One of the main challenges of toxicology is the accurate prediction of compound carcinogenicity. The default test model for assessing chemical carcinogenicity, the 2 year rodent cancer bioassay, is currently criticized because of its limited specificity.
Kleinjans, Jos +3 more
core +1 more source
Advanced Science, EarlyView.ACCE has a good alleviating effect on AFB1‐induced liver injury, and this alleviating effect is related to the PI3K‐AKT pathway regulated by ACCE and the butyrate metabolism of gut microbiota. ABSTRACT Aflatoxin B1 (AFB1) is a potent hepatotoxin commonly ingested through contaminated food. Abrus cantoniensis Hance, a traditional Chinese medicinal herb,
Hongjie Hu +12 more
wiley +1 more source
Angewandte Chemie, EarlyView.This review highlights an emerging anticancer approach integrating platinum agents into photodynamic therapy (PDT) and photoactivated chemotherapy (PACT) systems, further augmented by cancer cell membrane‐ and organelle‐targeting. By directing photoactivated platinum complexes from nontargeted distribution to cancer cells or defined subcellular sites ...
Shu Chen +3 more
wiley +2 more sources
Lung carcinogenicity of inhaled multi-walled carbon nanotube in rats
Particle and Fibre Toxicology, 2015 Multi-walled carbon nanotubes (MWCNTs) constitute one of the most promising types of nanomaterials in industry today. With their increasing use, the potential toxicity and carcinogenicity of MWCNT needs to be evaluated in bioassay studies using rodents ...
T. Kasai +7 more
semanticscholar +1 more source