Results 141 to 150 of about 230,259 (343)

ICH S1 prospective evaluation study: weight of evidence approach to predict outcome and value of 2-year rat carcinogenicity studies. A report from the regulatory authorities subgroup

Frontiers in Toxicology
Introduction: The International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH) initiated a process in 2012 to revise the S1B Guideline “Testing for Carcinogenicity of Pharmaceuticals”.
Todd Bourcier, Timothy McGovern, Tania Cavaliero, Geoffrey Ebere, Akiyoshi Nishikawa, Jihei Nishimura, Kumiko Ogawa, Markku Pasanen, Alisa Vespa, Jan Willem Van der Laan   +9 more
doaj   +1 more source

Cost-effectiveness of short-term tests for carcinogenicity

, 1986
Most chemicals to which we are exposed are not properly tested for carcinogenicity. The latest methods of in vitro testing provide a way of screening with sufficient accuracy to remedy this situation.
Lester B Lave (5455793), Gilbert S. Omenn (116828)   +1 more
core   +1 more source

Paediatric development of radiopharmaceutical imaging agents and radioligand therapeutics

British Journal of Clinical Pharmacology, EarlyView.
Abstract This review focuses on the development of radiopharmaceutical imaging agents and radioligand therapeutics for paediatric use. Nuclear medicine plays an important role in the diagnosis and treatment of various childhood conditions, including cancers, infections and brain disorders.
Justin L. Hay, Amandine Manon, Hunter Stephens, S. Y. Amy Cheung, Bart de Keizer, Erik T. te Beek   +5 more
wiley   +1 more source

Analysis of carcinogenicity data from the National Toxicology Program (http://ntp.niehs.nih.gov/).

, 2013
Analysis of carcinogenicity data from the National Toxicology Program (http://ntp.niehs.nih.gov/).
Lya G. Hernández (586116), Jan van Benthem (586117), George E. Johnson (586118)   +2 more
core   +1 more source

Efficacy, safety and cost‐effectiveness of CAR‐T therapy

British Journal of Clinical Pharmacology, EarlyView.
CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher, Amina Džidić‐Krivić, Emma Pinjic, Nejra Selak, Kanita Omerbasic, Alexandar Chupin, Andrej Belancic, Almir Fajkic   +7 more
wiley   +1 more source

Carcinogenicity of consumption of red and processed meat.

The Lancet Oncology, 2015
V. Bouvard, D. Loomis, K. Guyton, Y. Grosse, F. el Ghissassi, L. Benbrahim-Tallaa, N. Guha, Heidi Mattock, K. Straif   +8 more
semanticscholar   +1 more source

Patient‐reported outcomes and medication errors during oral antitumour therapy in paediatrics: Results from the youngAMBORA care programme

British Journal of Clinical Pharmacology, EarlyView.
Aim Increasing use of oral antitumour therapeutics (OAT) in paediatrics is associated with numerous advantages, but also with error‐prone aspects. Based on the randomized AMBORA trial including adults treated with various OAT, we developed a tailored pharmacological/pharmaceutical care programme for children and their caregivers during OAT treatment ...
Phyllis Lensker, Lisa Cuba, Frank Dörje, Martin F. Fromm, Markus Metzler   +4 more
wiley   +1 more source

Corrigendum: Mequindox Induced Genotoxicity and Carcinogenicity in Mice

Frontiers in Pharmacology, 2018
Qianying Liu, Qianying Liu, Zhixin Lei, Qin Wu, Deyu Huang, Shuyu Xie, Shuyu Xie, Xu Wang, Xu Wang, Yuanhu Pan, Yuanhu Pan, Zonghui Yuan, Zonghui Yuan, Zonghui Yuan, Zonghui Yuan   +14 more
doaj   +1 more source

The application of KI.C57-ras2.0 mouse in the carcinogenicity evaluation of medical devices—carcinogenicity evaluation of a novel hemodialyzer

Annals of Medicine
Introduction Alternative transgenic mouse models, such as rasH2, have been developed as to replace the traditional 2-year rodent carcinogenicity study.
Han Wang, Yu-ting Chen, Chang-jun Mu, Zhu Meng, Chen-Yu Zhao, Liu Yang, Rui-qin Guan, Rui Wang, Fan-shan Qiu, Dan-dan Chen, Qian-qian Han   +10 more
doaj   +1 more source

Accelerating green heterocyclic synthesis: Convergence of AI, automation, and sustainable chemistry

Bulletin of the Korean Chemical Society, EarlyView.
Green heterocyclic synthesis and data‐driven tools such as AI, high‐throughput experimentation, continuous flow, and self‐driving laboratories have developed largely in parallel. This review connects them and asks how green metrics such as E‐factor and PMI might serve as explicit optimization targets rather than post‐hoc measures, toward sustainable ...
Noor Aisyah Ahmad Shah, Amirreza Mottafegh, Su‐Hyun Yoo, Jongwoon Kim, Minseon Byeon, Juhwan Noh, Yea‐Lee Lee, Jin Suk Myung, Gwang‐Noh Ahn   +8 more
wiley   +1 more source