Results 161 to 170 of about 34,592 (264)

Artificial Intelligence in Colonoscopy Surveillance for Lynch Syndrome: Emerging Evidence, Lessons Learned From Average‐Risk Populations, and Future Directions

International Journal of Cancer, EarlyView.
ABSTRACT Lynch syndrome (LS) is the most common hereditary colorectal cancer (CRC) syndrome and is characterized by an accelerated adenoma‐carcinoma sequence, a relatively higher prevalence of flat and subtle CRC precursor lesions, and exceptionally high adenoma miss rates despite intensive colonoscopy surveillance.
Robert Hüneburg, Querijn N. E. van Bokhorst, Evelien Dekker, Jacob Nattermann   +3 more
wiley   +1 more source

Aumolertinib Versus Osimertinib as First‐Line Treatment for EGFR‐Mutant Non‐Small Cell Lung Cancer: A Retrospective Real‐World Multicenter Study

International Journal of Cancer, EarlyView.
As third‐generation EGFR‐tyrosine kinase inhibitors, both aumolertinib and osimertinib demonstrate clinical efficacy for non‐small cell lung adenocarcinoma, especially in patients with brain metastases. Currently, head‐to‐head studies comparing these two agents in real‐world settings are scarce.
Jinxia Wang, Ping Qi, Jinhua Li, Na Wang, Caihong Fu, Lixin Liu, Shuping Li, Xiao Li, Xiaoming Hou, Hui Qiao   +9 more
wiley   +1 more source

An Industry Perspective on Key Considerations for the ICH S13 Guidance: Nonclinical Safety Evaluations of Oligonucleotide-Based Therapeutics. [PDF]

Int J Toxicol
Sisler JD, Andersson P, Brown A, Harbison C, Irrechukwu O, Lightfoot H, Maes M, Mukherjee S, Parry JD, Schumacher J, Westlind Johnsson A, Yang Y, Harper TA.   +12 more
europepmc   +1 more source

New‐Onset Type 2 Diabetes Mellitus and Cancer Risk: A Matched Cohort Study in China Kadoorie Biobank

International Journal of Cancer, EarlyView.
ABSTRACT The prevalence of type 2 diabetes mellitus (T2DM) is rising rapidly in China and is linked to increased cancer risk, but causality remains unclear due to biases. We examined the causal effect of T2DM on cancer risk using bias‐minimizing methods.
Mengying Wang, Owen Tipping, Bowen Liu, Derrick A. Bennett, Baiyong Shen, Siyi Zou, Shulin Zhao, Richard M. Martin, Matthew Sperrin, Andrew G. Renehan   +9 more
wiley   +1 more source

Two-Year Inhalation Studies in Mice and Rats With HFO-1234ze(E), a Near Zero Global Warming Potential Propellant for Use in Pressurized Metered Dose Inhalers. [PDF]

Int J Toxicol
Giffen P, Jacobsen M, Cartwright J, Hall R, Waterhouse N, Carter P, Saul J, Wright L, Aberg P, Platz S.   +9 more
europepmc   +1 more source

The Association Between Human Papillomavirus and Prostate Cancer: A Systematic Review and Meta‐Analysis

International Journal of Cancer, EarlyView.
ABSTRACT Human papillomavirus (HPV), the necessary cause of cervical cancer, is associated with an increased risk of other anogenital cancers. While HPV has frequently been detected in prostate specimens, its role in prostate carcinogenesis remains controversial. We synthesized and meta‐analyzed the epidemiological literature on the association between
Sarah Botting‐Provost, Kristy Ng, Cassandra Laurie, Rodrigo Noorani, Mariam El‐Zein, Eduardo L. Franco   +5 more
wiley   +1 more source

Summary of the Safety Assessment Data of the Most Common Organogermanium Food Ingredient, Asaigermanium (Poly-trans-[(2-carboxyethyl)germasesquioxane]). [PDF]

J Food Sci
Doiyama S, Nakamura T.
europepmc   +1 more source

Non–AIDS‐Defining Cancer Incidence in People With HIV in Milan, Italy, 2000–2023: Temporal Trends and Comparison With the General Population

International Journal of Cancer, EarlyView.
ABSTRACT People with HIV (PWH) are living longer, but contemporary data on non–AIDS‐defining cancers (NADCs) in Italy remain limited. We assessed incident cancers in a retrospective cohort of PWH in Milan, Italy, between January 2000 and December 2023. Follow‐up was grouped into 2000–2007, 2008–2015, and 2016–2023. Incidence rates (IRs) were calculated
Giacomo Pozza, Maddalena Matone, Letizia Oreni, Giorgia Carrozzo, Beatrice Caloni, Maria Vittoria Cossu, Davide Moschese, Anna Lisa Ridolfo, Cristina Gervasoni, Cinzia Fasola, Nicla La Verde, Davide Dalu, Spinello Antinori, Andrea Gori, Andrea Giacomelli   +14 more
wiley   +1 more source

Carcinogenicity of vinyl acetate: evidence from multiple data streams. [PDF]

Environ Health
Li K, Ricker K, Tsai FC, Cheng V, Osborne G, Guha N, Elmore S, Alvarado-Cruz I, Sandy MS, Sun M.   +9 more
europepmc   +1 more source

Efficacy and related factors of levonorgestrel‐releasing intrauterine system combined with metformin in fertility‐preserving treatment for atypical endometrial hyperplasia and early endometrial cancer: A retrospective cohort study

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective To compare the efficacy of the levonorgestrel‐releasing intrauterine system combined with metformin versus oral progestin combined with metformin in fertility‐preserving treatment for patients with atypical endometrial hyperplasia and early endometrial cancer, and to analyze related factors affecting efficacy.
Pengpeng Gu, Jialu Gao, Yuxin Li, Mei Huang, Xiaoshuang Wang, Xin Zhao   +5 more
wiley   +1 more source