Results 171 to 180 of about 34,592 (264)

Unveiling toxicological adverse outcomes: toward construction and simulation of large-scale networks. [PDF]

Toxicol Sci
Ikonomi N, Ketter N, Pepe MAA.
europepmc   +1 more source

Advances in Immunological Combination Therapy for Colorectal Cancer

iMetaMed, EarlyView.
Review the progress of combined immunotherapy for colorectal cancer. ABSTRACT Immune checkpoint inhibitors (ICIs) have been utilized extensively and shown to be therapeutically beneficial in the treatment of solid tumors in recent years. Nonetheless, considerable heterogeneity in Colorectal cancer (CRC) requires careful consideration.
Jiayue Wu, Rongbo Wen, Tianshuai Zhang, Fuao Cao, Xiaoming Zhu, Liqiang Hao, Wei Zhang, Guanyu Yu   +7 more
wiley   +1 more source

Impact of carbon-based fibers morphologies on their carcinogenic potential. [PDF]

Part Fibre Toxicol
Wagner A, Schulz F, Meyer-Plath A, Dahlmann F, Rittinghausen S, Schaudien D.   +5 more
europepmc   +1 more source

Microbiome—pancreatic cancer crosstalk: From tumor biology to therapeutic intervention

iMetaOmics, EarlyView.
The intratumoral microbiome acts as a critical regulator in pancreatic cancer progression and therapeutic resistance. This comprehensive review delineates the origins of pancreatic microbes, elucidates their multifaceted mechanisms in driving immune suppression, metabolic reprogramming, and stromal desmoplasia, and highlights the clinical potential of ...
Yuqin Xie, Jingyuan Ye, Sheng Wang, Maoyun Liu, Fengsheng Dai, Mingzhen Bai, Yi Wang, Athena Savoji, Yu Wang, Phillip B. Hylemon, Huiping Zhou, Hui Li, Dewei Li   +12 more
wiley   +1 more source

Network toxicology and molecular docking elucidate the hepatotoxic and carcinogenic mechanisms of potassium sorbate validated by in vitro assays. [PDF]

Sci Rep
Li Y, Dai W, Li J, Mo W, Xu X.
europepmc   +1 more source

Climate change amplifies global mycotoxin exposure: Emerging risks and sustainable solutions

iMetaOmics, EarlyView.
Climate change intensifies mycotoxin contamination through rising temperatures, elevated CO2, and altered precipitation. Global surveys reveal a high and widespread prevalence of major mycotoxins in staple cereals, with low‐income countries bearing the greatest burden.
Mengyao Xue, Zheng Qu, Tingting Jiang, Antonio F. Logrieco, Antonio Moretti, Ke Dong, Yanpo Yao, Qi Zhang, Peiwu Li   +8 more
wiley   +1 more source

A comprehensive analysis reveals the molecular mechanisms linking preservatives to prostate cancer risk. [PDF]

Discov Oncol
Zhu X, Li Y, Liu Z, Wu Q, Deng Q.
europepmc   +1 more source

Human biomarker navigator

iMeta, EarlyView.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

Machine learning driven LD₅₀ prediction for cancer risk assessment using modern molecular language models. [PDF]

Front Oncol
Sharma T, Sona P, Jung J.
europepmc   +1 more source

Environmental chemicals and the tumor immune microenvironment

iMeta, EarlyView.
Impact of representative environmental chemicals on tumor immune microenvironment (TIME). Representative environmental chemicals are ubiquitously distributed across air, soil, aquatic systems, and biota. These toxicants enter the human body via multiple exposure routes, including inhalation, dietary intake, and dermal absorption, subsequently ...
Tongtong Zhang, Yanxia Hu, Weiran Zhang, Yang Jin, Chaoyang Sun, Afshin Samali, Shunqing Xu, Xia Sheng   +7 more
wiley   +1 more source