Results 71 to 80 of about 33,845 (314)

Machine Learning for Green Solvents: Assessment, Selection and Substitution

Advanced Science, EarlyView.
Environmental regulations have intensified demand for green solvents, but discovery is limited by Solvent Selection Guides (SSGs) that quantify solvent sustainability. Training a machine learning model on GlaxoSmithKline SSG, a database of sustainability metrics for 10,189 solvents, GreenSolventDB is developed. Integrated with Hansen solubility metrics,
Rohan Datta, Janhavi Nistane, Abhishek Sose, Harikrishna Sahu, Rampi Ramprasad   +4 more
wiley   +1 more source

Oral cancer among Khat users: finding evidence from DNA analysis of nine cancer-related gene mutations

BMC Oral Health, 2021
Background Khat leaves contain the alkaloid cathinone. Research shows that khat might provoke toxicity, mutagenicity, as well as carcinogenicity. Methods Two groups were identified as khat abusers and were categorized by abuse time and diagnosis of oral ...
Sawsan Abdullah Alshahrani, Wedad Saeed Al-Qahtani, Nawaf Abdulrahman Almufareh, Dalia Mostafa Domiaty, Gadah Ibraheem Albasher, Fatmah Ahmed Safhi, Fatima Abdullah AlQassim, Mashael Alhumaidi Alotaibi, Tahani Mohamed Al-Hazani, Bassam Ahmed Almutlaq   +9 more
doaj   +1 more source

Mutagenicity assessment of aerosols in emissions from wood combustion [PDF]

, 2011
Mestrado em Estudos AmbientaisPolycyclic aromatic hydrocarbon (PAH) extracts of PM2.5 collected from combustion of seven wood species and briquettes were tested for mutagenic activities using Ames test with Salmonella typhimurium TA98 and TA100.
Binh Ngan Vu
core   +1 more source

Green fluorescent diamidines as diagnostic probes for trypanosomes [PDF]

, 2014
LED fluorescence microscopy offers potential benefits to the diagnosis of human African trypanosomiasis, as well as to other aspects of diseases management, such as detection of drug resistant strains.
Arvind Kumar, Bailey, Baker, Barrett, Bieler, Bridges, Carter, Chappuis, David W. Boykin, de Koning, Federica Giordani, Hanscheid, Jones, Keiser, Lanteri, Manoj Munde, Mathis, Mathis, Matovu, Michael P. Barrett, Minion, Mohamed A. Ismail, Paine, Steingart, Stewart, Vincent, W. David Wilson, Wilson   +27 more
core   +1 more source

Gemella morbillorum Promotes Colorectal Carcinogenesis: LPBDCP‐Mediated Invasion Activates Ras Signaling and Destabilizes p53

Advanced Science, EarlyView.
ABSTRACT Gut microbiota dysbiosis promotes colorectal cancer (CRC) tumorigenesis. A global fecal metagenomic analysis identified Gemella morbillorum as a key contributor to the CRC‐associated microbiota. Fluorescence in situ hybridization revealed that Gemella morbillorum is enriched in CRC tumor tissues compared to adjacent normal tissues.
Zhen Wang, Jia Zhang, Haojie Lu, Jingjing Ni, Shuaishuai Yang, Yuting Shi, Shuo Zhang, Pei Zhang, Li Liu   +8 more
wiley   +1 more source

Current investigations into the genotoxicity of zinc oxide and silica nanoparticles in mammalian models in vitro and in vivo: carcinogenic/genotoxic potential, relevant mechanisms and biomarkers, artifacts, and limitations

International Journal of Nanomedicine, 2014
Jee Young Kwon,1,* Preeyaporn Koedrith,2,* Young Rok Seo1 1Department of Life Science, Institute of Environmental Medicine, Dongguk University, Seoul, Republic of Korea; 2Faculty of Environment and Resource Studies, Mahidol University, Phuttamonthon ...
Kwon JY, Koedrith P, Seo YR
doaj  

A regulatory perspective on the applicability of NAMs in genotoxicity and carcinogenicity assessment in EU: current practices and future directions

Environment International
New Approach Methodologies (NAMs) are gaining significant momentum globally to reduce animal testing and enhance the efficiency and human relevance of chemical safety assessment.
Cecilia Bossa, Silvia Alivernini, Cristina Andreoli, Gabriele Aquilina, Leonello Attias, Emilio Benfenati, Maria Dusinska, Naouale El Yamani, Henriqueta Louro, Francesca Marcon, Giuseppa Raitano, Elise Rundén-Pran, Maria Teresa Russo, Maria João Silva, Chiara Laura Battistelli   +14 more
doaj   +1 more source

Precision requirements in pesticide risk assessments: Contrasting value-of-information recommendations with the regulatory practice in the EU [PDF]

, 2016
Pesticides, while rendering immense agricultural benefits, potentially entail risks to human health and the environment. To limit these risks, market approval of a pesticide is typically conditional on an extensive risk assessment demonstrating its ...
Goeschl, Timo, Heyen, Daniel
core   +1 more source

Decoding IGLL5 Mutation‐Mediated BCR Signaling: A Novel Mechanism of CD8+ T Cell Exhaustion and Ocular MALT Lymphoma Progression

Advanced Science, EarlyView.
OAML harbors recurrent IGLL5 mutations that reinforce CD79A/CD79B‐associated BCR signaling. Mechanistic analysis of the S47G and A54G variants reveals induction of CXCL10/CXCL11, enhanced CD8+ T‐cell recruitment, and exhaustion‐associated dysfunction, supporting an immune‐tolerant niche.
Andi Zhao, Haoyu Wei, Chenyu Zhou, Xinping Sun, Shuyan Da, Haiyu Liu, Zijin Wang, Hui Zhu, Shiya Shen, Qing Shao, Qi Gong, Hu Liu, Xuejuan Chen   +12 more
wiley   +1 more source

Alternative methods for regulatory toxicology – a state-of-the-art review [PDF]

, 2014
This state-of-the art review is based on the final report of a project carried out by the European Commission’s Joint Research Centre (JRC) for the European Chemicals Agency (ECHA).
BREMER Susanne, BURTON JULIEN, CASATI Silvia, COECKE Sandra, CORVI Raffaella, DESPREZ BERTRAND, DUMONT CORALIE, GOULIARMOU VARVARA, GOUMENOU MARINA - PARASKEVI, GRAEPEL RABEA, GRIESINGER Claudius, HALDER MARIA ELISABETH, JANUSCH ROI Annett, KIENZLER AUDE, MADIA FEDERICA, MUNN SHARON, NEPELSKA MALGORZATA, PAINI ALICIA, PRICE Anna, PRIETO PERAITA Maria Del Pilar, ROLAKI ALEXANDRA, SCHAEFFER MICHAEL WILHELM, TRIEBE Jutta, VIEGAS BARROSO JOAO FILIPE, WHELAN Maurice, WITTWEHR Clemens, WORTH Andrew, ZUANG Valerie   +27 more
core   +1 more source