Results 81 to 90 of about 34,330 (305)

Genome-Wide Significance Levels and Weighted Hypothesis Testing [PDF]

, 2009
Genetic investigations often involve the testing of vast numbers of related hypotheses simultaneously. To control the overall error rate, a substantial penalty is required, making it difficult to detect signals of moderate strength.
Roeder, Kathryn, Wasserman, Larry
core   +1 more source

Spatial Profiling Reveals Distinct Molecular and Immune Evolution of Mouse Lung Adenocarcinoma Precancers with or Without Carcinogen Exposure

Advanced Science, EarlyView.
Tumor evolution in lung adenocarcinoma is shaped by genetic alterations and spatial immune dynamics. By integrating whole‐exome sequencing, imaging mass cytometry, and spatial transcriptomics across two mouse models, this study reveals how mutational burden, immune infiltration, and cell–state interactions evolve during early and late carcinogenesis ...
Bo Zhu, Muhammad Aminu, Pingjun Chen, Jian‐Rong Li, Chuanpeng Dong, Chenyang Li, Yanhua Tian, Shao‐Wei Lu, Hong Chen, Chenxi Ma, Xin Hu, Jie Ye, Andrew Y. Liu, Beibei Huang, Frank R. Rojas, Parra Cuentas. Edwin Roger, Ou Shi, Monique B. Nilsson, Alissa Poteete, Khaja B. Khan, Wei Lu, Luisa M. Solis Soto, Junya Fujimoto, Cara Haymaker, Ignacio I. Wistuba, Zhubo Wei, Linghua Wang, Don L. Gibbons, Ken Chen, Alexandre Reuben, Jason M. Schenkel, John V. Heymach, Chao Cheng, Jia Wu, Jianjun Zhang   +34 more
wiley   +1 more source

TRIM38 Suppresses Breast Cancer Progression via Modulating SQSTM1 Ubiquitination and Autophagic Flux

Advanced Science, EarlyView.
TRIM38, an E3 ubiquitin ligase, suppresses breast cancer progression by inhibiting proliferation, migration, and invasion. Downregulated in breast tumor, its loss correlates with poor prognosis. Mechanistically, TRIM38 mediates K63‐linked ubiquitination of SQSTM1/p62 at K420, disrupting SQSTM1‐LC3 interaction and blocking autophagic flux.
Shan Jiang, Lijuan Wang, Dianwen Han, Peng Su, Bing Chen, Wenjing Zhao, Tong Chen, Ning Zhang, Xiaolong Wang, Yiran Liang, Yaming Li, Chen Li, Xi Chen, Dan Luo, Qifeng Yang   +14 more
wiley   +1 more source

Is Duhuo Jisheng Tang containing Xixin safe? A four-week safety study

Chinese Medicine, 2010
Background Though the nephrotoxicity and carcinogenicity of aristolochic acid (AA) are known, its safety in clinical usage is not clear. This study aims to evaluate the safety of Duhuo Jisheng Tang (DJT) in a four-week study to treat osteoarthritis (OA ...
Chen Pau-Chung, Lai Jung-Nien, Hsieh Shu-Ching, Chen Chao-Chung, Chen Huey-Jen, Wang Jung-Der   +5 more
doaj   +1 more source

Retrospective on U.S. Health Risk Assessment: How Others Can Benefit [PDF]

, 1995
Dr. Paustenbach reviews the scientific underpinnings of about twenty years of health risk assessment practice and their implications for environmental policy.
Paustenbach, Dennis J.
core   +1 more source

Precision requirements in pesticide risk assessments: Contrasting value-of-information recommendations with the regulatory practice in the EU [PDF]

, 2016
Pesticides, while rendering immense agricultural benefits, potentially entail risks to human health and the environment. To limit these risks, market approval of a pesticide is typically conditional on an extensive risk assessment demonstrating its ...
Goeschl, Timo, Heyen, Daniel
core   +1 more source

Disrupting the Formation of YAP Condensates Promotes the Activation of AMPKα to Inhibit the Progression of Primary Liver Cancer

Advanced Science, EarlyView.
This study systematically investigates the function and molecular mechanisms of YAP phase separation in multiple primary liver cancers. These findings provide novel insights into phase separation‐mediated primary liver cancer development and validate targeted disruption of this process as an effective therapeutic strategy for primary liver cancer ...
Shuang‐Zhou Peng, Jia‐Jia Liang, Yun‐Feng Zhan, Wei‐Xun Wu, Wan‐Li Xu, Xiao‐Kun Zhang, Li‐Jun Cai, Fu‐Quan Jiang   +7 more
wiley   +1 more source

Cheek Advancement Flap for BCC of the Nose: The Nitrosamine Contamination During the Combined Drug Intake as Important Skin Cancer Triggering Factor

Acta Medica Bulgarica
The emerging insights and (hypo)theses regarding the pathogenesis of skin cancer are particularly intriguing, as they introduce a novel and unconventional etiopatho- genetic factor: the presence of contaminants, specifically nitrosamines, in medications ...
Tchernev G., Kordeva S.
doaj   +1 more source

Environmental Toxicology: The legacy of Silent Spring [PDF]

, 2004
The transcript of a Witness Seminar held by the Wellcome Trust Centre for the History of Medicine at UCL, London, London, on 12 March 2002. First published by the Wellcome Trust Centre for the History of Medicine at UCL, 2004.©The Trustee of the Wellcome
Christie, DA, Tansey, EM
core  

Male reproductive health and environmental xenoestrogens [PDF]

, 1996
EHP is a publication of the U.S. government. Publication of EHP lies in the public domain and is therefore without copyright. Research articles from EHP may be used freely; however, articles from the News section of EHP may contain photographs or ...
A Giwercman, Ansell PE, Avellan L, B Jégou, Baird DD, Baumrucker GO, Berkowitz GD, Berkowitz GS, Bibbo M, Bigler WJ, Bj N, Blom K, Bostofte E, Bradbury RB, Bromage NR, Brown LM, Buemann B, Campbell DM, Cassidy A, Chung CS, Clemens MJ, Conover MR, Copeland PA, Czeizel A, Depue RH, Driscoll SG, E Rajpert-De Meyts, Forman D, Fox GA, Freeman HC, Frst P, Fry DM, Gray LEJ, Gray LEJ, Greco TL, H Leffers, Hakulinen T, Halevi HS, Harris LE, Hautau ER, Henderson BE, Hirasing RA, Hohlbein R, Hsieh J-T, Ikeda Y, J A McLachlan, J C Larsen, J Müller, J Sumpter, J Toppari, Jennings ML, Jost A, Kallen B, Kallen B, Korach KS, Kupfer D, L J Guillette, Leatherland JF, Leatherland JF, McDonnell DP, McIntosh R, N E Skakkebaek, N Keiding, Newbold RR, O Meyer, P Christiansen, P Grandjean, P Jouannet, Panayotou PC, Pearce N, Peterson RE, Pohjanvirta R, R Sharpe, Rey RA, Schumacher GFB, Scully RE, Sell S, Soto AM, Sweet RA, T K Jensen, T Scheike, Thomas KB, Thomas KB, Thorup J, Tryphonas L, Turscott B, Vessey MP, Wallace HM, Ward B, Wilkinson TJ   +89 more
core   +2 more sources