Results 171 to 180 of about 35,315 (245)

Personal radio use and risk of cancers among police officers in Great Britain: Results from the airwave health monitoring study

open access: yesInternational Journal of Cancer, EarlyView.
What's New? Terrestrial trunked radio (TETRA) is the standard digital communication system used by police and other emergency services in Great Britain. During active use, TETRA emits radiofrequency electromagnetic fields, which are potentially carcinogenic in humans.
Chiara Di Gravio   +2 more
wiley   +1 more source

HIF2A as a prognostic and clinical therapeutic target in ovarian clear cell carcinoma

open access: yesInternational Journal of Cancer, EarlyView.
What's New? Ovarian clear cell carcinoma is highly associated with hypoxia. Hypoxia‐inducible factor 2A (HIF2A) is a key regulator of hypoxic responses, but its role in ovarian clear cell carcinoma remains unclear. This study demonstrated the unfavorable prognostic significance of HIF2A expression in ovarian clear cell carcinoma.
Mengxin Jiang   +15 more
wiley   +1 more source

Global Burden of Hematologic Malignancies From 1990 to 2021 With Projections to 2030: A Systematic Analysis for the Global Burden of Disease Study 2021

open access: yesiNew Medicine, EarlyView.
ABSTRACT This study aimed to comprehensively analyze the epidemiological trends and global burden of hematologic malignancies (HM) from 1990 to 2021 and to project trends up to the year 2030. Using data from the Global Burden of Disease (GBD) Study 2021, we analyzed the age‐standardized rates (ASRs) and the trends of HM from 1990 to 2021. Decomposition
Ziyuan Shen   +5 more
wiley   +1 more source

Targeting GRP78 and the Proteostasis Network to Break the Therapeutic Ceiling in Neuroendocrine Prostate Cancer

open access: yesiNew Medicine, EarlyView.
ABSTRACT HSPA5 (also known as GRP78/BiP) is a master regulator of the endoplasmic reticulum (ER) stress response and a key node in the proteostasis network. In neuroendocrine prostate cancer (NEPC), an aggressive, therapy‐refractory lineage that emerges under pressure from androgen receptor (AR) directed therapies, GRP78 is upregulated and co‐opted to ...
Amos Olalekan Akinyemi   +14 more
wiley   +1 more source

Chinese pan‐cancer patient genomic characteristics: A comprehensive analysis based on the National Cancer Center–Clinical Diagnostics Knowledgebase real‐world clinical sequencing cohort

open access: yesInterdisciplinary Medicine, EarlyView.
We assembled National Cancer Center–Clinical Diagnostics Knowledgebase, a clinical genomic knowledgebase of 6935 tumors with matched normal samples, revealing key somatic alterations and actionable variants (70.2% of the cohort). Enrichment of certain different gene mutations was observed between Chinese and American populations, along with a strong ...
Hongrui Li   +10 more
wiley   +1 more source

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