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ENVIRONMENTAL MUTAGENS AND CARCINOGENS

Annual Review of Genetics, 1978
INTRODUCTION METHODOLOGY Mutation Tests Using Microbes .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . Repair test and rec-assay .. Mutation test .
M, Nagao, T, Sugimura, T, Matsushima
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Nitrosamines as Environmental Carcinogens

Nature, 1970
Human cancer might be caused by nitrosamines formed in the body from ingested nitrites and secondary amines. Cooking could be a source of secondary amines.
W, Lijinsky, S S, Epstein
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Genetic determinant and environmental carcinogens

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 1998
2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is the most abundant mutagenic heterocyclic amine (HCA) present in cooked foods. PhIP induces colon cancer in male Fischer 344 (F344) rats, and its role in human colon carcinogenesis has been suspected.
M, Nagao   +5 more
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Environmental carcinogens and large bowel cancer

Nature, 1976
THE geographical variation in the incidence of large bowel cancer together with the increased incidence found in migrants from low risk to high risk areas support the view that environmental factors are involved in the aetiology of this disease1. These environmental factors are thought to be largely dietary although other influences have not been ...
A G, Renwick, B S, Drasar
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Mutagenicity and carcinogenicity of environmental chemicals

Regulatory Toxicology and Pharmacology, 1982
Abstract This article presents a brief analysis of the qualitative relationship between carcinogenicity and mutagenicity (DNA-damaging activity), based on chemicals which are known to be or suspected of being carcinogenic to humans and/or to experimental animals. Details have been published elsewhere ( Tomatis et al. , 1982 ; Bartsch et al. , 1982
H, Bartsch, L, Tomatis, C, Malaveille
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Environmental Carcinogens

Archives of Environmental Health: An International Journal, 1969
The acceleration of tumor production in mice by repeated application of polycyclic aromatic hydrocarbon carcinogens of high and low potency in the presence of cocarcinogenic compounds is described. Experiments exploring the concentration levels of carcinogen and cocarcinogen necessary to produce tumors demonstrate that there is a 1,000-fold increase in
E, Bingham, H L, Falk
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Monitoring Human Exposure to Environmental Carcinogens

1991
One of the long range goal of research in chemical carcinogenesis is the identification of individuals at increased risk of cancer development. Cancer is a multistep, multistage process in which many factors effect ultimate risk. The initiating event in the process of chemical carcinogenesis is the binding of the reactive electrophilic species of the ...
R M, Santella   +4 more
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Environmental chemical carcinogens and liver cancer

Journal of Toxicology and Environmental Health, 1979
An appraisal is made of these chemical carcinogens available in the human environment that have been implicated in the etiology of liver cancer. The possible role of mycotoxins is discussed in detail, in particular the association between the aflatoxins and liver cancer in Africa and the Far East.
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