Results 61 to 70 of about 36,244 (99)
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The evaluation of the carcinogenicity of environmental substances
Regulatory Toxicology and Pharmacology, 1984A review of the current status of carcinogenicity assessment leads to a number of observations that raise specific questions about the conduct and techniques of these bioassays. An approach is suggested that avoids many of the scientific controversies associated with the use of excessively high doses that cause secondary toxicity, leading to a promoter-
A C, Kolbye, C J, Carr
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Issues in the Regulation of Environmental Carcinogens
Journal of Public Health Policy, 1982UCH of the effort to reduce our vulnerability to cancer is directed toward an application of the regulatory process to the identification of persons at high risk and the reduction of their exposures to toxic substances for which there is evidence of carcinogenic potential.
B, Walker, D R, Wade
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Mutagenicity and carcinogenicity of environmental chemicals
Regulatory Toxicology and Pharmacology, 1982Abstract This article presents a brief analysis of the qualitative relationship between carcinogenicity and mutagenicity (DNA-damaging activity), based on chemicals which are known to be or suspected of being carcinogenic to humans and/or to experimental animals. Details have been published elsewhere ( Tomatis et al. , 1982 ; Bartsch et al. , 1982
H, Bartsch, L, Tomatis, C, Malaveille
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Genetic determinant and environmental carcinogens
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 19982-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is the most abundant mutagenic heterocyclic amine (HCA) present in cooked foods. PhIP induces colon cancer in male Fischer 344 (F344) rats, and its role in human colon carcinogenesis has been suspected.
M, Nagao +5 more
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Archives of Environmental Health: An International Journal, 1969
The acceleration of tumor production in mice by repeated application of polycyclic aromatic hydrocarbon carcinogens of high and low potency in the presence of cocarcinogenic compounds is described. Experiments exploring the concentration levels of carcinogen and cocarcinogen necessary to produce tumors demonstrate that there is a 1,000-fold increase in
E, Bingham, H L, Falk
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The acceleration of tumor production in mice by repeated application of polycyclic aromatic hydrocarbon carcinogens of high and low potency in the presence of cocarcinogenic compounds is described. Experiments exploring the concentration levels of carcinogen and cocarcinogen necessary to produce tumors demonstrate that there is a 1,000-fold increase in
E, Bingham, H L, Falk
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Perspectives on Comparing Risks of Environmental Carcinogens
JNCI Journal of the National Cancer Institute, 1988In 1987, investigators (Ames et al.) concluded that the risks of man-made industrial carcinogens and pesticides (outside of the workplace) are trivial compared with the risks of naturally occurring carcinogens found mostly in the diet. They used a ranking system based on human exposure and rodent potency (HERP) data to arrive at this conclusion.
F, Perera, P, Boffetta
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Environmental carcinogens and large bowel cancer
Nature, 1976THE geographical variation in the incidence of large bowel cancer together with the increased incidence found in migrants from low risk to high risk areas support the view that environmental factors are involved in the aetiology of this disease1. These environmental factors are thought to be largely dietary although other influences have not been ...
A G, Renwick, B S, Drasar
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Environmental carcinogens and mutational pathways in atherosclerosis
International Journal of Hygiene and Environmental Health, 2015Atherosclerosis is associated with DNA damage in both circulating and vessel-wall cells and DNA adducts derived from exposure to environmental mutagens are abundant in atherosclerotic vessels. Environmental chemical carcinogens identified as risk factor for atherosclerosis include polycyclic aromatic hydrocarbons (benzo(a)pyrene, dimethylbenz(a ...
Pulliero, A. +5 more
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Monitoring Human Exposure to Environmental Carcinogens
1991One of the long range goal of research in chemical carcinogenesis is the identification of individuals at increased risk of cancer development. Cancer is a multistep, multistage process in which many factors effect ultimate risk. The initiating event in the process of chemical carcinogenesis is the binding of the reactive electrophilic species of the ...
R M, Santella +4 more
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Electrochemical methods for monitoring of environmental carcinogens
Fresenius' Journal of Analytical Chemistry, 2001The use of modern electroanalytical techniques, namely differential pulse polarography, differential pulse voltammetry on hanging mercury drop electrode or carbon paste electrode, adsorptive stripping voltammetry and high performance liquid chromatography with electrochemical detection for the determination of trace amounts of carcinogenic N-nitroso ...
J, Barek +4 more
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