Results 131 to 140 of about 310,687 (304)
Cell-mediated mutagenesis by chemical carcinogens [PDF]
, 1978 The cell-mediated mutation system, with the proper choice of metabolizing cells, can be used to detect the mutagenic activities of different classes of chemical carcinogens.
Huberman, E., Langenbach, R.
core
Relative DNA Concentration in Mouse Epidermis Treated with Carcinogens or Croton Oil
, 1971 Histophotometry of skin nuclei (stained by the Feulgen reaction) of newborn mice treated with the chemical carcinogens, 7,12-dimethylbenz(a)anthracene and urethan, and the promoting agent croton oil, revealed an early increase in DNA concentration in ...
Humberto Garcia, Silvia Leiva
core +1 more source
Efficacy, safety and cost‐effectiveness of CAR‐T therapy
British Journal of Clinical Pharmacology, EarlyView.CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher +7 more
wiley +1 more source
The NADPH oxidase NOX4 regulates redox and metabolic homeostasis preventing HCC progression
Hepatology, EarlyView., 2022 Loss of NOX4 in HCC tumor cells induces metabolic reprogramming in a Nrf2/MYC‐dependent manner to promote HCC progression. Abstract Background and Aims The NADPH oxidase NOX4 plays a tumor‐suppressor function in HCC. Silencing NOX4 confers higher proliferative and migratory capacity to HCC cells and increases their in vivo tumorigenic potential in ...
Irene Peñuelas‐Haro +14 more
wiley +1 more source
Spatial heterogeneity of KRAS mutations in colorectal cancers in northern France
Cancer Management and Research, 2019 Anthony Turpin,1–3 Michael Genin,4 Mohamed Hebbar,1,2 Florent Occelli,5 Caroline Lanier,5 Francis Vasseur,4 Clotilde Descarpentries,6 Diane Pannier,7 Anne Ploquin1 1Medical oncology unit, Hôpital Claude Huriez, F-59000 Lille, France; 2Lille ...
Turpin A +8 more
doaj
"Light" cigarettes and exposure to carcinogens
, 2005 To assess whether smoking "light" cigarettes reduces the amount of tobacco-specific carcinogens in the body, scientists at the University of Minnesota measured the level of carcinogen uptake in smokers who were using regular, light, and ultralight ...
University of Minnesota
core
British Journal of Clinical Pharmacology, EarlyView.Aim Increasing use of oral antitumour therapeutics (OAT) in paediatrics is associated with numerous advantages, but also with error‐prone aspects. Based on the randomized AMBORA trial including adults treated with various OAT, we developed a tailored pharmacological/pharmaceutical care programme for children and their caregivers during OAT treatment ...
Phyllis Lensker +4 more
wiley +1 more source
Hepatology, EarlyView., 2022 Mesenchymal stem cells subset, educated by TNF‐α, are involved to generate inflammatory microenvironment and promote hepatocarcinogenesis Abstract Background and Aims Increasing evidence suggests that mesenchymal stem cells (MSCs) home to injured local tissues and the tumor microenvironment in the liver.
Chen Zong +9 more
wiley +1 more source
International commission for protection against environmental mutagens and carcinogens
, 1980 The objectives, organization structure, and activities of the newly established International Commission for Protection against Environmental Mutagens and Carcinogens (I.C.P.E.M.C.) are presented.
Lohman, P.H.M.
core
Accelerating green heterocyclic synthesis: Convergence of AI, automation, and sustainable chemistry
Bulletin of the Korean Chemical Society, EarlyView.Green heterocyclic synthesis and data‐driven tools such as AI, high‐throughput experimentation, continuous flow, and self‐driving laboratories have developed largely in parallel. This review connects them and asks how green metrics such as E‐factor and PMI might serve as explicit optimization targets rather than post‐hoc measures, toward sustainable ...
Noor Aisyah Ahmad Shah +8 more
wiley +1 more source