Results 181 to 190 of about 284,642 (297)

An Improved Synthesis of Ionizable Lipids D‐Lin‐KC2‐DMA and D‐Lin‐MC3‐DMA

open access: yesEuropean Journal of Organic Chemistry, EarlyView.
A new route to ionizable lipid KC2 through the double alkylation of TosMIC with linoleyl tosylate avoids problematic reactions, is higher yielding, and requires three fewer steps. Lipid MC3 is also more efficiently prepared by the new method. Considerable interest exists in ionizable lipids (ILs) for the delivery of nucleic acid therapeutics. While not
Ardalan Nabi   +5 more
wiley   +1 more source

Electrochemical Biosensors for Cancer Biomarker Detection: Basic Concept, Design Strategy and Cutting‐Edge Development

open access: yesElectrochemical Science Advances, EarlyView.
ABSTRACT Cancer is a result of uncontrolled cell growth with the potential to damage or spread to another part of the body. It is the deadliest disease in the world; therefore, rapid and sensitive detection is essential to fight it. In the past few decades, many diagnosis tools have been developed to detect cancer and monitor therapy progress.
Md Mobarok Karim, Tahera Lasker
wiley   +1 more source

Interpretation of in vitro concentration‐response data for risk assessment and regulatory decision‐making: Report from the 2022 IWGT quantitative analysis expert working group meeting

open access: yesEnvironmental and Molecular Mutagenesis, EarlyView.
Abstract Quantitative risk assessments of chemicals are routinely performed using in vivo data from rodents; however, there is growing recognition that non‐animal approaches can be human‐relevant alternatives. There is an urgent need to build confidence in non‐animal alternatives given the international support to reduce the use of animals in toxicity ...
Marc A. Beal   +14 more
wiley   +1 more source

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