Results 201 to 210 of about 284,642 (297)

Review of Transcriptomic Biomarkers That Predict In Vitro Genotoxicity in Human Cell Lines

open access: yesEnvironmental and Molecular Mutagenesis, EarlyView.
ABSTRACT The current genotoxicity testing paradigm provides little mechanistic information, has poor specificity in predicting carcinogenicity in humans, and is not suited to assessing a large number of chemicals. Genomic technologies enable the characterization of genome‐wide transcriptional changes in response to chemical treatments that can inform ...
Heng‐Hong Li   +7 more
wiley   +1 more source

Global and Chinese trends in acute myeloid leukemia burden (1990-2021): a comprehensive analysis based on the GBD study. [PDF]

open access: yesFront Med (Lausanne)
Lu X   +9 more
europepmc   +1 more source

Critical Evaluation of Methods for the Identification of Aneugens

open access: yesEnvironmental and Molecular Mutagenesis, EarlyView.
ABSTRACT The genotoxic potential of chemicals must be evaluated in regulatory safety assessment settings, including but not limited to, the development of new pharmaceuticals, industrial chemicals, food and cosmetic ingredients, and agrochemicals. Initial assessment of the chromosome‐damaging potential of chemicals is often conducted in mammalian cells
Xiaowen Sun   +8 more
wiley   +1 more source

Identifying Gene Predictors of Chemicals Linked With Breast Cancer: A Machine Learning Analysis of MCF7 Cellular Transcriptomic Screening Data

open access: yesEnvironmental and Molecular Mutagenesis, EarlyView.
ABSTRACT Breast cancer is the most prevalent cancer in women and has been linked to exposure to environmental chemicals. However, many chemicals have not been evaluated for relationships with this outcome. In this study, we analyzed RNA sequencing data from human breast cancer‐derived MCF7 cells exposed to hundreds of individual chemicals.
Lauren E. Koval   +2 more
wiley   +1 more source

Sustainable polypropylene chair: A life cycle assessment and cost analysis of industrial production

open access: yesEnvironmental Progress &Sustainable Energy, EarlyView.
Abstract Due to their multiple properties, including flexibility, lightness, and strength, thermoplastics are an essential material in the development of processes at both industrial and domestic levels. However, thermoplastics are often derived from polymers synthesized using non‐renewable petroleum resources. This has environmental consequences.
Lucrezia Maggi   +4 more
wiley   +1 more source

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