Results 131 to 140 of about 304,742 (351)

DNA methylation biomarkers for noninvasive detection of triple‐negative breast cancer using liquid biopsy

International Journal of Cancer, Volume 152, Issue 5, Page 1025-1035, 1 March 2023., 2023
What's new? While early diagnosis of triple‐negative breast cancer (TNBC) is associated with heightened responsiveness to chemotherapy, biomarkers that can be detected noninvasively are needed to support early TNBC diagnosis. Our study suggests that such markers may exist in the form of methylation signatures in cell‐free DNA. Evaluation of methylation
Mehdi Manoochehri, Nasim Borhani, Clarissa Gerhäuser, Yassen Assenov, Maximilian Schönung, Thomas Hielscher, Brock C. Christensen, Min Kyung Lee, Hermann‐Josef Gröne, Daniel B. Lipka, Thomas Brüning, Hiltrud Brauch, Yon‐Dschun Ko, Ute Hamann   +13 more
wiley   +1 more source

Does the correlation between EBNA-1 and p63 expression in breast carcinomas provide a clue to tumorigenesis in Epstein-Barr virus-related breast malignancies?

Brazilian Journal of Medical and Biological Research, 2004
Several investigators have identified Epstein-Barr virus (EBV) particles in breast carcinomas, a fact that supports a role for EBV in mammary tumorigenesis. The possible mechanism involved in this process is not clear.
A. Ribeiro-Silva, L.N.Z. Ramalho, S.B. Garcia, S. Zucoloto   +3 more
doaj   +3 more sources

Potential biomarkers of ductal carcinoma in situ progression

BMC Cancer, 2020
Background Ductal carcinoma in situ is a non-obligate precursor of invasive breast carcinoma and presents a potential risk of over or undertreatment. Finding molecular biomarkers of disease progression could allow for more adequate patient treatment.
Raquel Spinassé Dettogni, Elaine Stur, Ana Carolina Laus, René Aloísio da Costa Vieira, Márcia Maria Chiquitelli Marques, Iara Viana Vidigal Santana, José Zago Pulido, Laura Fregonassi Ribeiro, Narelle de Jesus Parmanhani, Lidiane Pignaton Agostini, Raquel Silva dos Reis, Eldamária de Vargas Wolfgramm dos Santos, Lyvia Neves Rebello Alves, Fernanda Mariano Garcia, Jéssica Aflávio Santos, Diego do Prado Ventorim, Rui Manuel Reis, Iúri Drumond Louro   +17 more
doaj   +1 more source

HNF3α Targets Nckap1l and Promotes Renal Fibrosis Following Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
Hepatocyte Nuclear Factor 3 alpha (HNF3α) is significantly upregulated in renal tubular epithelial cells of CKD patients and fibrotic mice. Deletion of HNF3α mitigates IRI‐induced renal fibrosis, while overexpression worsens it. HNF3α directly regulates NCK‐associated protein 1‐like (Nckap1l), whose overexpression exacerbates fibrosis.
Ling Hou, Yan Guo, Shuang Xu, Mi Bai, Weidong Cao, Yue Zhang, Zhanjun Jia, Aihua Zhang   +7 more
wiley   +1 more source

A new subtype of papillary ductal carcinoma in situ with tall cell and reversed polarity morphology: a rare case report

BMC Women's Health
Background According to previous studies, tall cell carcinoma with reversed polarity can be easily distinguished from ductal carcinoma in situ based on the absence of myoepithelium and a typical histologic feature.
Ruiqi Zhong, Ziyi Chang, Xiuhong Wang, Dingrong Zhong   +3 more
doaj   +1 more source

Macrophages promote the progression of premalignant mammary lesions to invasive cancer. [PDF]

, 2017
Breast cancer initiation, progression and metastasis rely on a complex interplay between tumor cells and their surrounding microenvironment. Infiltrating immune cells, including macrophages, promote mammary tumor progression and metastasis; however, less
Anderson, Bissell, Blair, Colombatti, Colombo, Condeelis, Coussens, De Palma, Earp, Ghosh, Green, Gunaratne, Hermoso, Hylton, Jensen, Jirstrom, Lewis, Lidereau, Luo, Lydon, Maatta, Machado, Mantovani, Naber, Naldini, Ochiai, Ochoa, Piemonti, Pollard, Pollard, Pollard, Pollard, Pollard, Porse, Rosen, Rosen, Rosen, Sarukhan, Schwertfeger, Schwertfeger, Shen, Strassmann, Suthipintawong, Ullrich, Van Ginderachter, Van Ginderachter, van Rooijen, Visvader, Wang, West   +49 more
core   +1 more source

Cytoplasmic HuR expression is a prognostic factor in invasive ductal breast carcinoma.

Cancer Research, 2005
HuR is a ubiquitously expressed mRNA-binding protein. Intracellular localization of HuR is predominantly nuclear, but it shuttles between the nucleus and the cytoplasm. In the cytoplasm it can stabilize certain transcripts.
Mira Heinonen, P. Bono, K. Narko, Sung-Hee Chang, J. Lundin, H. Joensuu, H. Furneaux, T. Hla, C. Haglund, A. Ristimäki   +9 more
semanticscholar   +1 more source

Zonated Copper‐Driven Breast Cancer Progression Countered by a Copper‐Depleting Nanoagent for Immune and Metabolic Reprogramming

Advanced Science, EarlyView.
Spatially resolved multiomics reveals that high‐copper zones are closely associated with tumor metastasis, immune‐desert phenotypes, and oxidative‐phosphorylation (OXPHOS)‐dependent proliferation. A targeted bacterial nanovesicle delivering copper‐depleting agents effectively reduces tumor copper levels, inhibits OXPHOS‐dependent tumor growth, and ...
Lin Chen, Saibo Ma, Hao Wu, Lingna Zheng, Yunpeng Yi, Guangnian Liu, Baoyi Li, Jiayi Sun, Yang Du, Bing Wang, Yike Liu, Cheng Zhang, Jing Chang, Yuheng Pang, Wenjing Wang, Meng Wang, Motao Zhu   +16 more
wiley   +1 more source

Secretory Breast Carcinoma: A Case Report with MRI Findings

대한영상의학회지, 2019
Secretory carcinoma of the breast is an extremely rare, clinically and histologically distinct variant of invasive ductal carcinoma, with an indolent growth pattern and a more favorable prognosis than that of typical ductal carcinoma.
Sung Hee Shin, Hye Jung Kim, Won Hwa Kim, Hoseok Lee, Wan Wook Kim, Ji Young Park, Dong Sug Kim   +6 more
doaj   +1 more source

BRCA1 and PARP1 mRNA expression during progression from normal breast to ductal carcinoma in situ and invasive breast cancer: a laser microdissection study

Polish Journal of Pathology, 2019
The contribution of DNA damage repair mechanisms to the progression of normal breast to ductal carcinoma in situ (DCIS) and invasive ductal carcinoma is largely unknown. The purpose of this report was to assess the mRNA expression levels of two important
Jolanta Hybiak, Pawel Domagala, Wenancjusz Domagala   +2 more
doaj   +1 more source