Results 151 to 160 of about 2,584,744 (346)

Primary Neuroendocrine Carcinoma of the Palate: A Case Report

Journal of Craniomaxillofacial Research
Primary neuroendocrine carcinomas (NECs) of the oral cavity represent exceptionally rare malignancies (< 30 reported cases globally), posing significant diagnostic challenges due to histological mimicry of other round cell tumors and nonspecific ...
Bahareh Fattahi, Arash Esmaeili, Akram Fallah, Saeedeh Khalesi   +3 more
doaj  

GATA3 is a sensitive marker for primary genital extramammary paget disease: An immunohistochemical study of 72 cases with comparison to gross cystic disease fluid protein 15 [PDF]

, 2017
Cao, Dengfeng, et al,
core   +2 more sources

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

Primary endometrial large cell neuroendocrine carcinoma with melanocytic differentiation

Autopsy and Case Reports, 2018
High-grade endometrial carcinomas are aggressive neoplasms of difficult histological classification. Neuroendocrine differentiation in endometrial carcinomas is rare.
Lucinda Calheiros Guimarães, Priscila Leandro Garcia, João Badaró Castro Filho, Antonio Carlos Oliveira Meneses   +3 more
doaj  

Tarlatamab for Large Cell Neuroendocrine Carcinoma in a Young Adult: A Case Report

JTO Clinical and Research Reports
A 20-year-old man with metastatic large cell neuroendocrine carcinoma of the lung was treated with the delta-like ligand 3–targeting bispecific T cell engager, tarlatamab. Treatment was complicated by transient cytokine release syndrome but resulted in a
Shetal A. Patel, MD, PhD, Young Whang, MD, PhD, Chaely Medley, NP, Kevin Chen, PharmD, Jasmine Jordan, BS, Dante Bortone, PhD, Benjamin Vincent, MD, PhD, Jared Weiss, MD   +7 more
doaj   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Primary Cutaneous Lymphoma-Associated Pseudoepitheliomatous Hyperplasia Masquerading as Squamous Cell Carcinoma in a Young Adult

Acta Medica Iranica, 2015
Primary cutaneous anaplastic large cell lymphoma is a T-cell malignancy with atypical CD30 positive lymphocytes. Pseudoepitheliomatous hyperplasia is an uncommon finding in primary cutaneous anaplastic large cell lymphoma, and may mimic squamous cell ...
Mahsa Ansari, Farid Azmoodeh Ardalan, Masoumeh Najafi, Azadeh Goodarzi, Alireza Ghanadan   +4 more
doaj  

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Lung cancer at a university hospital in Saudi Arabia: A four-year prospective study of clinical, pathological, radiological, bronchoscopic, and biochemical parameters

Annals of Thoracic Medicine, 2010
Objectives and Background: Lung cancer accounts for 4% of all newly diagnosed cancers in Saudi Arabia. The pattern of presentation is unknown. The objectives of this study were to assess the clinical, radiological, pathological, biochemical and ...
Alamoudi Omer
doaj  

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source