Results 171 to 180 of about 825,494 (348)

Quantification and expert evaluation of evidence for chemopredictive biomarkers to personalize cancer treatment. [PDF]

, 2017
Predictive biomarkers have the potential to facilitate cancer precision medicine by guiding the optimal choice of therapies for patients. However, clinicians are faced with an enormous volume of often-contradictory evidence regarding the therapeutic ...
Beckman, Robert A., Boca, Simina M., Brody, Jonathan R., Madhavan, Subha, Marshall, John L., Pishvaian, Michael J., Rao, Shruti, Riazi, Shahla, Yabar, Cinthya S.   +8 more
core   +1 more source

Unraveling the Molecular Mechanisms of Glioma Recurrence: A Study Integrating Single‐Cell and Spatial Transcriptomics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Glioma recurrence severely impacts patient prognosis, with current treatments showing limited efficacy. Traditional methods struggle to analyze recurrence mechanisms due to challenges in assessing tumor heterogeneity, spatial dynamics, and gene networks.
Lei Qiu, Yinjiao Fei, Jiaxuan Ding, Kexin Shi, Jinyan Luo, Yuchen Zhu, Xingjian Sun, Gefei Jiang, Yuandong Cao, Weilin Xu, Shu Zhou   +10 more
wiley   +1 more source

Clinical Spectrum and Outcomes of SOX1 Antibody‐Associated Paraneoplastic Neurological Syndromes: A Chinese Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background SOX1 antibody‐positive paraneoplastic neurological syndromes (PNS) exhibit significant population‐specific clinical heterogeneity. While Western cohorts predominantly manifest Lambert‐Eaton myasthenic syndrome (65%–80%), comprehensive clinical characterization and treatment response data in Asian populations remain critically ...
Jin‐Long Ye, Zu‐Ying Kuang, Bo Li, Meng‐Qiu Pan, Li‐Hua Zhou, Yang‐Yang Dai, Si‐Fen Xie, Xian‐Guang Lin, Ye‐Peng Hu, Li‐Hong Jiang, Zhan‐Hang Wang, Wei‐Jing Zhang   +11 more
wiley   +1 more source

Clinical and Molecular Characteristics Associated With Survival Among Patients Treated With Checkpoint Inhibitors for Advanced Non–Small Cell Lung Carcinoma: A Systematic Review and Meta-analysis

JAMA Oncology, 2017
C. Lee, J. Man, S. Lord, W. Cooper, M. Links, V. Gebski, R. Herbst, R. Gralla, T. Mok, J. Yang   +9 more
semanticscholar   +1 more source

Gold Nanoclusters as Dual Agents for Engineering Tumor Vascular Leakiness and Performing Photothermal Therapy

Advanced Functional Materials, EarlyView.
Many cancer nanotherapeutics, while potent, suffer from the inability to escape from the tumor vasculature, especially in the absence of endothelial permeability. In this work, ultrasmall gold nanoclusters could engineer nanomaterials induced endothelial leakiness (NanoEL) and harness strong NIR induced photothermal characteristics to suppress tumor ...
Nengyi Ni, Kuoran Xing, Bihan Zhang, Baoteng Wang, Yinglu Chen, Jianping Xie, Xiao Sun, Jinping Wang, David Tai Leong   +8 more
wiley   +1 more source

Current WHO guidelines and the critical role of immunohistochemical markers in the subclassification of non-small cell lung carcinoma (NSCLC): Moving from targeted therapy to immunotherapy.

Seminars in Cancer Biology, 2017
Lais Osmani, F. Askin, E. Gabrielson, Q. K. Li   +3 more
semanticscholar   +1 more source

Doxorubicin‐Loaded Metal–Organic Framework for Ferroptosis‐Enhanced Chemotherapy Through Sustained Zn Release and Glutathione Peroxidase Downregulation

Advanced Healthcare Materials, EarlyView.
A robust zinc‐based metal–organic framework (ZnMOF) enables dual functions of doxorubicin delivery and sustained Zn2+ release to trigger ferroptosis‐enhnaced chemotherapy. DOX@ZnMOF effectively depletes intracellular glutathione, suppresses GPX4, and elevates reactive oxygen species, leading to efficient oxidative DNA damage and apoptosis.
Xin Ma, Chenghua Deng, Chaoyu Wang, Langston Tilman, Jinhong Li, Wenbin Lin   +5 more
wiley   +1 more source

Assessing Tumor-Infiltrating Lymphocytes in Solid Tumors: A Practical Review for Pathologists and Proposal for a Standardized Method from the International Immuno-Oncology Biomarkers Working Group: Part 2: TILs in Melanoma, Gastrointestinal Tract Carcinomas, Non-Small Cell Lung Carcinoma and Mesothe

Advances in Anatomic Pathology, 2017
S. Hendry, R. Salgado, T. Gevaert, P. Russell, Thomas John, Thomas John, B. Thapa, M. Christie, K. V. D. Vijver, M. V. Estrada, Paula I. Gonzalez-Ericsson, M. Sanders, B. Solomon, C. Solinas, G. V. D. Eynden, Yves Allory, Yves Allory, M. Preusser, J. Hainfellner, G. Pruneri, A. Vingiani, S. Demaria, F. Symmans, P. Nuciforo, L. Comerma, E. Thompson, Sunil R. Lakhani, Sunil R. Lakhani, Seong-Rim Kim, S. Schnitt, C. Colpaert, C. Sotiriou, S. Scherer, M. Ignatiadis, S. Badve, R. Pierce, G. Viale, N. Sirtaine, F. Penault-Llorca, Tomohagu Sugie, S. Fineberg, S. Paik, A. Srinivasan, A. Richardson, Yihong Wang, Yihong Wang, E. Chmielik, J. Brock, Douglas B. Johnson, J. Balko, S. Wienert, V. Bossuyt, S. Michiels, N. Ternès, N. Burchardi, S. Luen, S. Luen, P. Savas, P. Savas, F. Klauschen, P. Watson, Brad H. Nelson, Brad H. Nelson, C. Criscitiello, S. O'toole, D. Larsimont, R. Wind, G. Curigliano, F. André, M. Lacroix-Triki, Mark van de Vijver, F. Rojo, G. Floris, S. Bedri, J. Sparano, D. Rimm, T. Nielsen, Z. Kos, S. Hewitt, Baljit Singh, G. Farshid, S. Loibl, K. Allison, N. Tung, S. Adams, K. Willard-Gallo, H. Horlings, Leena Gandhi, Leena Gandhi, Andre Moreira, F. Hirsch, M. Dieci, M. Urbanowicz, I. Brčić, Konstanty Korski, F. Gaire, H. Koeppen, Amy C. Y. Lo, Amy C. Y. Lo, J. Giltnane, M. Rebelatto, K. Steele, J. Zha, K. Emancipator, J. Juco, C. Denkert, J. Reis-Filho, S. Loi, S. Fox   +108 more
semanticscholar   +1 more source

A case of recurrent non-small-cell lung carcinoma and paraneoplastic Cushing's syndrome [PDF]

, 2006
AERTS, JG, ELTE, JW, MANINTVELD, OC, NOORLANDER, I, Praet, Marleen, Tournoy, Kurt, Van Meerbeeck, Jan   +6 more
core   +2 more sources

Strategies to Improve the Lipophilicity of Hydrophilic Macromolecular Drugs

Advanced Healthcare Materials, EarlyView.
Hydrophilic macromolecular drugs can be successfully lipidized by covalent attachment of lipids, by hydrophobic ion pairing with negatively or positively charged surfactants, and by dry or wet reverse micelle formation. Lipophilicity enhancement of hydrophilic macromolecules has several benefits including stability and bioavailability improvement ...
Sera Lindner, Stefan Keim, Soheil Haddadzadegan, Odile Fernandez Romero, Katrin Zöller, Gabriel Stern, Ilaria Cesi, Krum Kafedjiiski, Andreas Bernkop‐Schnürch   +8 more
wiley   +1 more source