Results 191 to 200 of about 689,752 (349)

Surfactant protein B gene variations enhance susceptibility to squamous cell carcinoma of the lung in German patients [PDF]

Genetic factors are thought to influence the risk for lung cancer. Since pulmonary surfactant mediates the response to inhaled carcinogenic substances, candidate genes may be among those coding for pulmonary surfactant proteins.
A Agudo, A Anzueto, A Plagens, B Robertson, B Stringer, C Amos, C Seifart, D Phelps, D Skillrud, G De Sanctis, H Suzuki, J Cifuentes, J Clark, J Clark, J Floros, J Liu, K Tokieda, KJB Morgenroth, L Allegra, L Breslow, L Nogee, M Greenblatt, M Greenblatt, M Wolf, N Vamvakopoulos, P Emrie, P Gehr, P von Wichert, R Low, S Lin, S Schürch, S Schürch, S Veletza, T Finley, T Pilot-Matias, U Seifart, V Gerber, W Weiss, Y Kakuta, Z Lin, Z Lin   +40 more
core   +2 more sources

Predictive uncertainty estimation in deep learning for lung carcinoma classification in digital pathology under real dataset shifts [PDF]

arXiv
Deep learning has shown tremendous progress in a wide range of digital pathology and medical image classification tasks. Its integration into safe clinical decision-making support requires robust and reliable models. However, real-world data comes with diversities that often lie outside the intended source distribution.
arxiv  

Understanding and measuring mechanical signals in the tumor stroma

FEBS Open Bio, EarlyView.
This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz, Chiara Cimmino, Maurizio Ventre, Alessandra Cambi   +3 more
wiley   +1 more source

Advances in combined neuroendocrine carcinoma of lung cancer

Pathology and Oncology Research
Lung cancer incidence and mortality rates are increasing worldwide, posing a significant public health challenge and an immense burden to affected families.
Zesen Han, Fujun Yang, Fang Wang, Huayu Zheng, Xiujian Chen, Hongyu Meng, Fenglei Li   +6 more
doaj   +1 more source

Non Small Cell Lung Carcinoma

Jurnal Radiologi Indonesia, 2017
Suwandi Suwandi, Evi Artsini, Lina Choridah   +2 more
openaire   +3 more sources

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source

Comparative single‐cell transcriptomic profiling of patient‐derived renal carcinoma cells in cellular and animal models of kidney cancer

FEBS Open Bio, EarlyView.
We generated and characterized clear cell renal cell carcinoma models using the patient‐derived RCC243 cell line—including cell culture, orthotopic, and metastatic tumors—via single‐cell RNA‐sequencing for comparisons between models and patient tumor datasets.
Richard Huang, Lynn Kee, Alexander Gont, Jalna Meens, Fraser G. Ferens, Meredith S. Irwin, Laurie Ailles, Scott A. Yuzwa, Claire M. Robinson, Michael Ohh   +9 more
wiley   +1 more source

Possible role of human ribonuclease dicer in the regulation of R loops

FEBS Open Bio, EarlyView.
R loops play an important role in regulating key cellular processes such as replication, transcription, centromere stabilization, or control of telomere length. However, the unscheduled accumulation of R loops can cause many diseases, including cancer, and neurodegenerative or inflammatory disorders. Interestingly, accumulating data indicate a possible
Klaudia Wojcik, Paulina Krzeminska, Anna Kurzynska‐Kokorniak   +2 more
wiley   +1 more source

Primary small‐cell carcinoma in the lung was found after the cold snare polypectomy of the small metastatic lesion in the cecum: A case report

DEN Open
Metastasis from small‐cell lung cancer to the colon is very rare. A 74‐year‐old man without respiratory or abdominal symptoms underwent a follow‐up lower gastrointestinal endoscopy after a polypectomy.
Daisuke Suto, Masashi Yoshida, Hidehiko Yamada, Takayuki Akita, Yosuke Osawa, Kiichi Sato, Takaaki Otake, Yoshimasa Nakazato, Nobuhito Arakawa, Hironori Ohdaira, Yutaka Suzuki, Yutaka Kohgo   +11 more
doaj   +1 more source

Long non‐coding RNAs as therapeutic targets in head and neck squamous cell carcinoma and clinical application

FEBS Open Bio, EarlyView.
Long non‐coding RNAs (lncRNAs) occupy an abundant fraction of the eukaryotic transcriptome and an emerging area in cancer research. Regulation by lncRNAs is based on their subcellular localization in HNSCC. This cartoon shows the various functions of lncRNAs in HNSCC discussed in this review.
Ellen T. Tran, Ruchi A. Patel, Amogh Chariyamane, Ratna B. Ray   +3 more
wiley   +1 more source