Results 221 to 230 of about 615,884 (310)

Clinofibrate Disrupts the SNORA80B/YTHDC1‐Driven M6A Modification to Suppress Cholesterol Metabolism and Cisplatin Resistance in ESCC

Advanced Science, EarlyView.
This study uncovers a non‐canonical role of SNORA80B in ESCC, showing it mediates AR‐driven metabolic reprogramming via N⁶‐methyladenosine (m6A) methylation. By binding YTHDC1, SNORA80B stabilizes cholesterol‐metabolic enzyme mRNAs and promotes tumor progression. The FDA‐approved drug clinofibrate inhibits SNORA80B by disrupting cholesterol homeostasis,
Hongyu Yuan, Ge Ge, LiQiu Liu, Sijun Hu, Miaomiao Tian, Yongzhan Nie, Zitong Zhao, Yongmei Song   +7 more
wiley   +1 more source

Hypertrophic Pulmonary Osteoarthropathy as an Initial Manifestation of Lung Cancer. [PDF]

Cureus
Mohamed Ahmed SK, Mohamedahmed YK, Fadl L, Salih D, Mohamedahmed RK.   +4 more
europepmc   +1 more source

Lung Non-Small Cell Squamous Carcinoma [PDF]

, 2020
openaire   +1 more source

Engineered Mesenchymal Stem Cell–NK Cell Complexes for Spatially Targeted and Functionally Revitalized Cancer Immunotherapy

Advanced Science, EarlyView.
IL‐15‐engineered stem cell–NK cell complexes, assembled via bioorthogonal chemistry, enable effective lung cancer immunotherapy. Abstract Natural killer (NK) cells represent a powerful immunotherapeutic strategy due to their intrinsic cytotoxicity and ability to target tumor cells independently of antigen presentation.
Qian Zhang, Bo Yin, Munaiwaier Sabier, Youlan Yang, Mengling Wu, Zhouping Zhao, Xuanzhi Luo, Yuehong Zhong, Xiuming Zhu, Jie Zhang, Jing Wang, Kai Chen, Fei Ruan, Wei Zhang, Zhimin Lu, Jiong Wang   +15 more
wiley   +1 more source

Different detection rates of brain metastasis in different pathological types of lung cancer by ¹⁸F-FAPI PET/CT. [PDF]

BMC Cancer
Li H, Li P, Zhu S, Hou W, Zhao W, Yu Q, Qin J, Hu X, Wei Y.   +8 more
europepmc   +1 more source

A Novel FGFR3‐Targeting Antibody‐Drug Conjugate Induces Tumor Cell Apoptosis through the cGAS–STING Pathway in Bladder Cancer

Advanced Science, EarlyView.
LZU‐WZLYCS01 is a novel FGFR3‐targeting ADC for bladder cancer with 7‐ethyl‐9‐fluorocamptothecin (A2) as its cytotoxic payload. LZU‐WZLYCS01 intracellularly releases A2, which targets MAD2L1 to activate the cGAS‐STING pathway and induce tumor cell apoptosis.
Shu Cui, Xiongfei Luo, Guangrui Fan, Jingqi Jiang, Yingru Wang, Enguang Yang, Jinpeng Ma, Ze Zhang, Yuhan Wang, Juan Wang, Dengtuo Wang, Hanzhang Wang, Liang Cheng, Junqiang Tian, Zhilong Dong, Yingqian Liu, Zhiping Wang   +16 more
wiley   +1 more source

Case Report: Two cases of non-small cell lung cancer with coexistence of <i>NTRK2</i> fusion and <i>EGFR</i> mutations. [PDF]

Front Oncol
Zhang Y, Zhang H, Li X.
europepmc   +1 more source

Improved radiotherapy for locally advanced Non-Small Cell Lung Carcinoma (NSCLC) patients [PDF]

, 2015
Ottosson, Wiviann
core  

Precise Regulation of Membrane Proteins: From Physical Technology to Biomolecular Strategy

Advanced Science, EarlyView.
This review summarizes the emerging strategies for the precise regulation of membrane proteins using physical stimuli and biomolecule‐based tools. These methods provide new insights into cell regulation and offer promising directions for future disease treatment.
Xiu Zhao, Qingqing Zhou, Mengli Li, Wen Zou, Zhenzhong Zhang, Jinjin Shi, Junjie Liu   +6 more
wiley   +1 more source

Small intestinal SMARCA4-deficient undifferentiated carcinoma with intussusception: A case report. [PDF]

Oncol Lett
Cai X, Liu S, Li L, Zhang Y, Guo Q, Chen Z, Qu M, Wang Y, Yang B, Yue X.   +9 more
europepmc   +1 more source