Results 231 to 240 of about 615,884 (310)

Occult Lung Non-Small Cell Carcinoma [PDF]

, 2020
openaire   +1 more source

Positive Feedback Loop of Histone Lactylation‐Driven HNRNPC Promotes Autophagy to Confer Pancreatic Ductal Adenocarcinoma Gemcitabine Resistance

Advanced Science, EarlyView.
Histone 3 lysine18 lactylation (H3K18la) drives heterogeneous nuclear ribonucleoprotein C (HNRNPC) overexpression, activating autophagy to mediate gemcitabine resistance by stabilizing TNF receptor‐associated factor 6 (TRAF6) mRNA. Concurrently, HNRNPC stabilizes aldehyde dehydrogenase 1 family member A3 (ALDH1A3) mRNA, which enhances glycolysis and ...
Xi‐Tai Huang, Jiao Chen, En‐Liang Zhu, Ming‐Jian Ma, Yang‐Yin‐Hui Yu, Ying‐Qin Zhu, Jing‐Yuan Ye, Jin‐Zhao Xie, Zi‐Yi Zhao, Xiao‐Yu Yin   +9 more
wiley   +1 more source

Novel immunohistochemical assay utilizing the INSM1 (SP493) antibody demonstrates high specificity and sensitivity in detecting primary neuroendocrine lung neoplasms. [PDF]

Diagn Pathol
Dvorak K, Gomez A, Sainz R.
europepmc   +1 more source

Unresectable Lung Non-Small Cell Carcinoma [PDF]

, 2020
openaire   +1 more source

Targeting the SOX9/TIMP1 Axis with iRGD‐Conjugated Nanoplatform Enhances Dendritic Cell Function and Photodynamic Immunotherapy in Gastric Cancer

Advanced Science, EarlyView.
This study identifies the SOX9/TIMP1 axis as a key regulator of immune evasion in gastric cancer. iRGD‐conjugated nanoparticles co‐delivering si‐SOX9, Ce6, and L‐Arg are developed to synergize with photodynamic therapy. The nanoplatform suppresses tumor growth, promotes dendritic cell maturation, and enhances CD8+ T‐cell activation, offering a ...
Banghua Zhong, Yijie Zhang, Honghu Wang, Lili Guo   +3 more
wiley   +1 more source

Integrative Mendelian randomization and spatial transcriptomics analysis reveals causal links between plasma lipidome and non-small cell lung cancer. [PDF]

Discov Oncol
Zhang B, Liu J, Guo Q, Wang H, Miao L, Zhou L.   +5 more
europepmc   +1 more source

EM2, a Natural Product MST1/2 Kinase Activator, Suppresses Non‐Small Cell Lung Cancer via Hippo Pathway Activation

Advanced Science, EarlyView.
EM2 directly binds to and activates MST1/2, enhancing their kinase activity and sequentially promoting LATS phosphorylation, which increases YAP phosphorylation. Consequently, YAP nuclear translocation is suppressed, leading to reduced transcription of downstream targets CTGF and CYR61, ultimately exerting a robust inhibitory effect on NSCLC cell ...
Siyu Yang, Huayan Xie, Qiang Lin, Liujin Zhou, Junxi Liu, Zekai Fang, Ziling Tang, Ruijie Yuan, Jinxuan Su, Sijia Li, Wenlin Wang, Mingyu Pan, Hao Wang, Xiaoyong Dai, Guocai Wang, Yubo Zhang   +15 more
wiley   +1 more source

Tanshinone IIA targets RNF123 to inhibit non-small cell lung cancer cell proliferation, migration and invasion via KAT2B-mediated H3K18ac modification. [PDF]

Oncol Lett
He Y, Zhang Y, Zhang J, Cai K.
europepmc   +1 more source

Lactylation Enhances the Activity of Lactate Dehydrogenase A and Promotes the Chemoresistance to Cisplatin Through Facilitating DNA Nonhomologous End Junction in Lung Adenocarcinoma

Advanced Science, EarlyView.
Lactylation, linked to glycolysis, is poorly understood in regulation. It is found that LDHA is lactylated at Lys81/Lys318 by AARS1, boosting its activity and cellular lactylation via positive feedback in LUAD. Lactylation regulates NHEJ‐related proteins; their delactylation impairs NHEJ and increases cisplatin sensitivity, offering anticancer insights.
Jizhuo Li, Wenze Xun, Xijie Wang, Ruiguang Luo, Qifan Hu, Zhaocai Zhou, Jian Yuan, Yanan Wang, Xiaorui Wan, Tao Zhao, Tianyu Han, Jian‐Bin Wang   +11 more
wiley   +1 more source

Esophago-tracheobronchial fistula induced by anlotinib: A case report. [PDF]

Medicine (Baltimore)
Qian Y, Qian J, Lv X.
europepmc   +1 more source