Results 141 to 150 of about 213,511 (352)

Meisoindigo Acts as a Molecular Glue to Target PKMYT1 for Degradation in Chronic Myeloid Leukemia Therapy

Advanced Science, EarlyView.
Meisoindigo targets PKMYT1 for degradation by acting as a molecular glue that enhances PKMYT1‐TRIM25 interaction, leading to K48‐linked ubiquitination and subsequent proteasomal degradation, thereby exerting therapeutic effects in chronic myeloid leukemia.
Zhao‐Xin Zhang, Shu‐Ying Li, Fang‐Fei Li, Qin‐Yan Shi, Cheng‐Yong Tan, Xiao‐Jing Wang, Mi Li, Yun‐Bao Liu, Jing Jin, Yong Li, Shi‐Shan Yu   +10 more
wiley   +1 more source

Modified Appleby Procedure with Arterial Reconstruction for Locally Advanced Pancreatic Adenocarcinoma: A Literature Review and Report of Three Unusual Cases. [PDF]

, 2016
BACKGROUND: Pancreatic body and tail ductal adenocarcinomas are often diagnosed with local vascular invasion of the celiac axis (CA) and its various branches. With such involvement, these tumors have traditionally been considered unresectable.
Lamb, Kathleen M., Latona, Jessica A., Maley, Warren R., Pucci, Michael J., Yeo, Charles J.   +4 more
core   +1 more source

Expression of p16 protein and cyclin d1 in periampullary carcinomas [PDF]

, 2011
Objective: The majority of the tumors in periampullary region are pancreatic and ampulla of Vater carcinomas. The aim of this study was to compare histopathological features of ampulla of Vater carcinomas with pancreatic ductal adenocarcinomas and to ...
Ersin Tuncer, Nese Calli Demirkan, Nilay Sen Turk, Sema Arici, Suleyman Ender Duzcan   +4 more
core   +1 more source

Differential Diagnosis for Pancreatic Cysts in CT Scans Using Densely-Connected Convolutional Networks [PDF]

arXiv, 2018
The lethal nature of pancreatic ductal adenocarcinoma (PDAC) calls for early differential diagnosis of pancreatic cysts, which are identified in up to 16% of normal subjects, and some of which may develop into PDAC. Previous computer-aided developments have achieved certain accuracy for classification on segmented cystic lesions in CT.
arxiv  

COPS5 Triggers Ferroptosis Defense by Stabilizing MK2 in Hepatocellular Carcinoma

Advanced Science, EarlyView.
COPS5, which is overexpressed in HCC in an amplification‐ and ATF4‐dependent manner, stabilizes MK2 through deubiquitination and, in turn, induces HSPB1 activation, protecting HCC cells from ferroptosis and thus promoting sorafenib resistance and tumor progression. Abstract Sorafenib, which is proven to serve as a potent ferroptosis inducer, is used as
Ai‐Ling Luo, Wen‐Ying Zheng, Qiong Zhang, Yan Yuan, Mei‐Qi Li, Kai Du, An‐Ran Gao, Li‐Jun Pei, Jie Xie, Wen‐Hao Chen, Long Zhang, Xiu‐Zhu Guo, Xiao‐Ran Yang, Chao Zeng, Guo‐Hua Yang, Min Deng   +15 more
wiley   +1 more source

Diagnosing primary pancreatic acinar cell carcinoma – Clinical correlation of radiological/molecular imaging, histopathologic features and whole genome/transcriptome profiling, and review of the literature

Current Problems in Cancer: Case Reports, 2023
Pancreatic acinar cell carcinoma (ACC) is a rare pancreatic neoplasm, often eluding clinicians because of the lack of diagnosis awareness and expert knowledge regarding clinical, radiological and pathological characteristics of ACC.
Kevin Tran, Owen W.J. Prall, Catherine Mitchell, Angela Chou, Anthony J. Gill, Sean M Grimmond, Grace Kong, Gareth Kiernan, Cristina Torche, Lara Lipton, Benjamin Thomson, HS Ko   +11 more
doaj  

Pancreatic acinar cell carcinoma: A review on molecular profiling of patient tumors

World Journal of Gastroenterology, 2017
Pancreatic carcinomas with acinar differentiation are rare, accounting for 1%-2% of adult pancreatic tumors; they include pancreatic acinar cell carcinoma (PACC), pancreatoblastoma, and carcinomas of mixed differentiation.
A. Al-Hader, R. Al-Rohil, Haiyong Han, D. V. Von Hoff   +3 more
semanticscholar   +1 more source

Extracellular Vesicular Delta‐Like Ligand 3 and Subtype Transcription Factors for Small Cell Lung Cancer Diagnosis

Advanced Science, EarlyView.
Small cell lung cancer (SCLC) harbors high molecular heterogeneity. Using a new liquid biopsy assay, SCLC subtypes can be identified by measuring mRNA of subtype transcription factors (ASCL1, POU2F3, and NEUROD1) in exosome‐rich extracellular vesicles. Combining with Delta‐like ligand 3 (DLL3) mRNA in exosomes and its membrane protein in extracellular ...
Hong Li, Chi‐Ling Chiang, Kwang Joo Kwak, Hsin‐Lun Lee, Xinyu Wang, Giulia Romano, Michela Saviana, Robin Toft, Tai‐Shan Cheng, Yuehshih Chang, Bi‐Da Hsiang, Guan‐Wan Liu, Xiaokui Mo, Yifan Ma, Junjie Pan, Xilal Y. Rima, Truc Nguyen Kim, Eduardo Reategui, Chia‐Ning Shen, Yeh‐Shiu Chu, Carlo Croce, Peter Mu‐Hsin Chang, Yi‐Chen Yeh, David P. Carbone, Chi‐Ying F. Huang, Chi‐Lu Chiang, Patrick Nana‐Sinkam, L. James Lee   +27 more
wiley   +1 more source

Comparing VIP and PD‐L1 expression as cancer biomarkers

ImmunoMedicine, Volume 2, Issue 2, December 2022., 2022
Abstract Immune checkpoint molecules are critical targets of cancer therapies due to their ability to modulate immune responses to cancer. Vasoactive intestinal peptide (VIP) has been proposed as an immune checkpoint molecule, but its predictive and prognostic values have not been established.
Jojo Y. Liu, Hanwen Zhang, Sruthi Ravindranathan, Taofeek K. Owonikoko, Bassel F. El‐Rayes, Yuan Liu, Edmund K. Waller   +6 more
wiley   +1 more source

PPAR-alpha: a novel target in pancreatic cancer [PDF]

, 2015
Background: Current targeted therapies in pancreatic cancer have been ineffective. The tumor stroma, including intra- and peri-tumoral inflammation and fibrosis, is increasingly implicated in pancreatic cancer.
Hua, Alexander Mach
core   +1 more source