Results 141 to 150 of about 89,882 (308)

MEK inhibitors cobimetinib and trametinib, regressed a gemcitabine-resistant pancreatic-cancer patient-derived orthotopic xenograft (PDOX). [PDF]

, 2017
A pancreatic ductal adenocarcinoma (PDAC), obtained from a patient, was grown orthotopically in the pancreatic tail of nude mice to establish a patient-derived orthotopic (PDOX) model.
Bouvet, Michael, Clary, Bryan M, Delong, Jonathan C, Hoffman, Robert M, Hwang, Ho Kyoung, Igarashi, Kentaro, Kawaguchi, Kei, Kiyuna, Tasuku, Lwin, Thinzar M, Murakami, Takashi, Unno, Michiaki   +10 more
core  

Regulation of pyruvate dehydrogenase complex: Dancing to different drums in cancer

International Journal of Cancer, EarlyView.
Abstract Mechanisms governing the regulation of pyruvate dehydrogenase complex (PDC) are markedly modified in cancer cells compared to normal cells. PDC activity in normal cells is controlled by the reversible phosphorylation of three serine residues by dedicated kinases and phosphatases.
Mulchand S. Patel, Todd C. Rideout
wiley   +1 more source

Radioterapia: papel actual en el cáncer de páncreas = Radiotherapy: its present role in pancreatic cancer

Iatreia, 2012
El cáncer de páncreas es una enfermedad de mal pronóstico, que presenta una tasa de supervivencia a 5 años de 5-15% luego de manejo radical. Su evolución agresiva, asociada a una sintomatología inespecífica, retarda el manejo; razón por la cual sólo ...
Mancera Morales, Juliana, Hoyos Duque, Sergio   +1 more
doaj  

Protein Induced by Vitamin K Absence or Antagonist‐II: Significantly Elevated in Obstructive Jaundice and Sepsis Patients Without Hepatocellular Carcinoma

Journal of Clinical Laboratory Analysis, EarlyView.
The PIVKA‐II produced by HCC may differ from that produced by obstructive jaundice and sepsis. Given that serum PIVKA‐II levels are abnormally elevated in patients with obstructive jaundice and sepsis, the results should be interpreted with caution in patients with hepatocellular carcinoma combined with these diseases. ABSTRACT Background PIVKA‐II is a
Ke Zhang, Xiarui Ye, Xianran Fu
wiley   +1 more source

Long‐Term Outcomes of Congenital Biliary Dilatation Surgery: A Single‐Center Study Highlighting the High Incidence of Complications Within 5 Years

Journal of Hepato-Biliary-Pancreatic Sciences, EarlyView.
ABSTRACT Background Congenital biliary dilatation (CBD) is a rare anomaly often treated surgically, yet postoperative complications remain a concern. This study aimed to evaluate the incidence, timing, and risk factors of such complications after CBD surgery.
Takuya Maeda, Hiroo Uchida, Chiyoe Shirota, Takahisa Tainaka, Satoshi Makita, Hajime Asai, Ami Utsunomiya, Yui Murata, Yaohui Guo, Jiahui Liu   +9 more
wiley   +1 more source

PPAR-alpha: a novel target in pancreatic cancer [PDF]

, 2015
Background: Current targeted therapies in pancreatic cancer have been ineffective. The tumor stroma, including intra- and peri-tumoral inflammation and fibrosis, is increasingly implicated in pancreatic cancer.
Hua, Alexander Mach
core   +1 more source

Early Definitive Surgery for Congenital Biliary Dilatation in Children Is Associated With Lower Morbidity: Comparison of Infant and School‐Age Children From 231 Consecutive Cases in a Multicenter Study in the Kyushu Area of Japan During the Past Decade

Journal of Hepato-Biliary-Pancreatic Sciences, EarlyView.
ABSTRACT Purpose There has been little discussion on the differences in characteristics and long‐term outcomes of congenital biliary dilation (CBD) by age group. Methods We conducted a regional multicenter study to investigate all pediatric cases of CBD in the Kyushu area of Japan over the past decade.
Masakazu Murakami, Koshiro Sugita, Shohei Maeda, Kina Miyoshi, Yusuke Yamane, Taichiro Kosaka, Shun Onishi, Makoto Hayashida, Toshiharu Matsuura, Kimio Asagiri, Motofumi Torikai, Yukihiro Tatekawa, Takeshi Yamanouchi, Taizo Hibi, Tatsuro Tajiri, Satoshi Ieiri   +15 more
wiley   +1 more source

BMI and Breast Subcutaneous Fat

Journal of Ultrasound in Medicine, EarlyView.
Objectives Obesity is closely associated with the occurrence and progression of breast cancer. While body mass index (BMI) is widely used to diagnose obesity, it has certain limitations. Subcutaneous fat thickness (SFT) also serves as an indicator of body composition. However, studies on breast SFT are scarce.
Shiyu Wang, Jin Zhou, Yunxia Huang, Dongdong Zheng, Ruoqing Hou, Shichong Zhou   +5 more
wiley   +1 more source

Data‐Independent Acquisition Mass Spectrometry in Tumor Classification and Cancer Biomarker Research

Mass Spectrometry Reviews, EarlyView.
Abstract Cancer treatment is far from optimal also because current classification systems do not reflect the complex molecular status of the tumor and its phenotype in sufficient detail. To construct molecular tumor classifiers, omics tools provide complex molecular data reflecting many aspects from genotype to phenotype.
Jan Simonik, Petr Lapcik, Pavla Bouchalova, Pavel Bouchal   +3 more
wiley   +1 more source

Intratumoral Nerve Phased Development: A Promising Therapeutic Target

Medicine Bulletin, EarlyView.
ABSTRACT The nervous system has emerged as a critical regulator of tumor biology, engaging in dynamic crosstalk with cancer cells. Although the protumorigenic role of innervation is well established, increasing attention is now directed toward reciprocal influences—how tumors actively shape and remodel local nerve networks within the tumor ...
Xiangxian Che, Hang Wang, Han Wang, Yi‐Zhou Jiang   +3 more
wiley   +1 more source