Results 161 to 170 of about 63,783 (265)

Impact of propofol‐based vs. volatile‐based anaesthesia on survival and recurrence after cancer surgery: a systematic review and meta‐analysis of randomised trials

Anaesthesia, EarlyView.
Summary Introduction Choice of peri‐operative anaesthetic technique may influence cancer recurrence, survival and mortality following curative surgery. Conflicting evidence exists on whether propofol‐based anaesthesia improves outcomes over volatile anaesthesia.
Ashmit Daiyan Mustafa, Pavan Shet, Sameen Shadman Sawdagar   +2 more
wiley   +1 more source

Diagnostic efficacy of endoscopic ultrasound-guided fine needle aspiration cytology in pancreatic lesions. [PDF]

Sci Rep
Mohanty P, Dehuri P, Narayan J.
europepmc   +1 more source

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

British Journal of Pharmacology, EarlyView.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown, Alan Armstrong, David J. Mann   +2 more
wiley   +1 more source

A Deep Dive into the Molecular and Immune Landscape of Undifferentiated Carcinomas with Osteoclast-like Giant Cells. [PDF]

Cells
Chang E, Shi J.
europepmc   +1 more source

Cancer pain: current practice and emerging targets

British Journal of Pharmacology, EarlyView.
Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye, Marcin Chwistek, Zhiting Gong, Vanessa Uzonwanne, Xiaojie Shi, Arpad Szallasi   +5 more
wiley   +1 more source

Case report: Metastatic pancreatic cancer to bilateral testes and spermatic cords. [PDF]

Urol Case Rep
Phillipi M, Roberts S, Yao D.
europepmc   +1 more source

Targeting KRAS for cancer therapy

British Journal of Pharmacology, EarlyView.
In recent years, therapeutics targeted against KRAS proto‐oncogene GTPase (KRAS)‐mutant cancers have seen significant progress. Herein we outline the biology and epidemiology of KRAS alterations at the lineage and allele levels, reviewing the clinical evidence for KRASG12C inhibition from the discovery of the recessive switch pocket to sotorasib ...
Jianlong Jia, Ruonan Liu, Tonia A. Adamide, Isis E. Fernandez, Georgios T. Stathopoulos   +4 more
wiley   +1 more source

Genotypic and Phenotypic Diversity as a Function of CRISPR-Directed Gene Knock-Out of <i>NRF2</i> in Pancreatic Adenocarcinoma Cells, a Feasibility Study. [PDF]

Biomolecules
McGill LP, Banas KH, Tiesi G, Kmiec EB.
europepmc   +1 more source

Usefulness of cytologic examination using pancreatic duct lavage fluid for diagnosis of pancreatic ductal carcinoma -A novel examination developed for pancreatic ductal carcinoma-

Progress of Digestive Endoscopy, 2003
Imamura, Tsunao, Yoshida, Hitoshi, Kitamura, Katsuya, Yanagawa, Tatsurou, Saito, Takeshi, Hanawa, Katsuhiro, Miyokawa, Akio, Ikegami, Akitoshi, Nozu, Fumihiko, Takahashi, Akira, Niikawa, Junichi, Tanaka, Shigeki, Kushima, Miki, Mitamura, Keiji   +13 more
openaire   +2 more sources

Bile‐Derived Exosomal miR‐196a/‐196b as Diagnostic Biomarkers Associated With Tumor Progression in Biliary Tract Cancer

Cancer Science, EarlyView.
Bile‐derived exosomal miR‐196a and miR‐196b are identified as novel biomarkers for biliary tract cancer. Serum miR‐196a levels are significantly elevated in advanced disease with metastasis, while both miRNAs contribute to tumor progression by promoting cancer cell proliferation and invasion.
Naotaka Kugiyama, Katsuya Nagaoka, Takehisa Watanabe, Michihiro Yoshida, Tadashi Toyohara, Cheng Pan, Kenyu Hashimoto, Fumiya Otsuka, Shinya Ushijima, Yukiko Uramoto, Hajime Iwasaki, Motohiro Yoshinari, Shunpei Hashigo, Kazuki Hayashi, Itaru Naitoh, Fumihiro Okumura, Hiromu Kondo, Kaiki Anbe, Hiromitsu Hayashi, Yoshihiro Komohara, Yasuhito Tanaka   +20 more
wiley   +1 more source