Results 41 to 50 of about 83,751 (271)

Exposures to pesticides and risk of cancer: Evaluation of recent epidemiological evidence in humans and paths forward

International Journal of Cancer, Volume 152, Issue 5, Page 879-912, 1 March 2023., 2023
Abstract Knowledge of the role in cancer etiology of environmental exposures as pesticides is a prerequisite for primary prevention. We review 63 epidemiological studies on exposure to pesticides and cancer risk in humans published from 2017 to 2021, with emphasis on new findings, methodological approaches, and gaps in the existing literature.
Haleigh Cavalier, Leonardo Trasande, Miquel Porta   +2 more
wiley   +1 more source

AI-based Carcinoma Detection and Classification Using Histopathological Images: A Systematic Review [PDF]

arXiv, 2022
Histopathological image analysis is the gold standard to diagnose cancer. Carcinoma is a subtype of cancer that constitutes more than 80% of all cancer cases. Squamous cell carcinoma and adenocarcinoma are two major subtypes of carcinoma, diagnosed by microscopic study of biopsy slides.
arxiv  

Sentinel lymph node mapping in endometrial cancer: A comparison of main national and international guidelines

International Journal of Gynecology &Obstetrics, Volume 160, Issue 1, Page 220-225, January 2023., 2023
Abstract Objectives To compare national and international guidelines regarding sentinel lymph node (SLN) mapping in endometrial cancer. Methods A descriptive comparative study of the National Comprehensive Cancer Network (NCCN), the Society of Gynecologic Oncology (SGO), the European Society of Gynecological Oncology (ESGO), the British Gynecological ...
Aharon Dick, Tamar Perri, Liron Kogan, Benny Brandt, Raanan Meyer, Gabriel Levin   +5 more
wiley   +1 more source

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source

A case of primary renal oncocytic tumor: Chromophobe renal cell carcinoma or oncocytoma?

IJU Case Reports, Volume 6, Issue 1, Page 18-21, January 2023., 2023
Introduction “Other oncocytic renal tumors of the kidney” is a new category constituted by 2022 WHO classification and different in the point of morphology and immunohistochemistory from typical oncocytic/eosinophilic renal tumors including chromophobe renal cell carcinoma and oncocytoma. Case presentation The patient was an 84‐year‐old woman in whom a
Kenta Matsui, Katsunori Uchida, Masahiro Kanai, Kana Asakawa, Miki Usui, Tetsuya Murata   +5 more
wiley   +1 more source

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

A rare case of a clear cell carcinoma in a female urethral diverticulum

IJU Case Reports, Volume 6, Issue 1, Page 77-80, January 2023., 2023
Introduction Urethral clear cell carcinoma is rare and often arises from a urethral diverticulum and rarely from the Müllerian duct. However, an explanation for this correlation remains unknown. Case presentation We report the case of a 46‐year‐old woman who presented with hypermenorrhea.
Masakazu Gonda, Toshiki Etani, Masahiko Isogai, Kengo Kawase, Takashi Nagai, Teruaki Sugino, Taku Naiki, Shuzo Hamamoto, Noriyasu Kawai, Takahiro Yasui   +9 more
wiley   +1 more source

Development and Evaluation of a Deep Neural Network for Histologic Classification of Renal Cell Carcinoma on Biopsy and Surgical Resection Slides [PDF]

arXiv, 2020
Renal cell carcinoma (RCC) is the most common renal cancer in adults. The histopathologic classification of RCC is essential for diagnosis, prognosis, and management of patients. Reorganization and classification of complex histologic patterns of RCC on biopsy and surgical resection slides under a microscope remains a heavily specialized, error-prone ...
arxiv  

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

Metastatic small‐cell carcinoma of the bladder that maintains a complete response to chemoradiation therapy

IJU Case Reports, Volume 6, Issue 1, Page 81-84, January 2023., 2023
Introduction Small‐cell carcinoma of the urinary bladder has a poor prognosis, and no standard treatment has been established. We encountered a case of a patient with metastasis in which complete response and long‐term survival were obtained by treating the primary lesion with a combination of irinotecan, carboplatin chemotherapy, and radiation therapy.
Shinya Miyazaki, Takashi Ueda, Ryosuke Tamai, Akihisa Ueno, Terukazu Nakamura   +4 more
wiley   +1 more source