Results 221 to 230 of about 1,472,301 (348)

Overall Survival and Updated Results for Sunitinib Compared With Interferon Alfa in Patients With Metastatic Renal Cell Carcinoma

Journal of Clinical Oncology, 2009
R. Motzer, Thomas E. Hutson, P. Tomczak, M. Michaelson, R. Bukowski, S. Oudard, S. Négrier, C. Szczylik, R. Pili, G. Bjarnason, X. Garcia-Del-Muro, J. Sosman, E. Solska, G. Wilding, John A Thompson, Sindy T. Kim, I. Chen, Xin Huang, R. Figlin   +18 more
semanticscholar   +1 more source

A dose‐finding population pharmacokinetic/pharmacodynamic model of ginisortamab, an anti‐gremlin‐1 monoclonal antibody, in patients with solid tumours

British Journal of Clinical Pharmacology, EarlyView.
Aims Ginisortamab, a first‐in‐class human monoclonal antibody for the treatment of advanced solid tumours, binds to gremlin‐1 and restores bone morphogenetic protein signalling. We used pharmacokinetic/pharmacodynamic (PK/PD) modelling to characterize the relationship between ginisortamab dose and serum gremlin‐1 binding, using model‐based simulations ...
Yin Cheong Wong, Luisa Rojas Chavarro, Paul Jones, David Egging, Wanchana Ungphakorn, Marta Valle, Ivan Matthews   +6 more
wiley   +1 more source

Integrated spatial and single‑cell transcriptomics maps disulfidptosis in renal cell carcinoma and reveals PDLIM1 as a prognostic biomarker and potential therapeutic target. [PDF]

Transl Oncol
Liu W, Liu X, Yi J, Tang Z, Dai Z, Song J, Chen T, Wang J, Wang J, Jiang W, Jiang A, Wu Z, Tang L, Jin Y, Chen Y, Wang L.   +15 more
europepmc   +1 more source

Engineered B7‐H3 Binding in Modular Gp2 Miniproteins

Biotechnology and Bioengineering, EarlyView.
ABSTRACT B7‐H3, an important immune checkpoint modulator of T‐cell function, is a tumor vasculature biomarker and is overexpressed in a variety of cancers. Its expression is associated with tumor growth, metastasis, and poor clinical prognosis, which makes B7‐H3 an appealing target for diagnostics and therapeutics.
Abbigael Harthorn, Hannah K. Windsor, Zachary Schmitz, Nathaniel Cheung, Ebube Agwaramgbo, Benjamin J. Hackel   +5 more
wiley   +1 more source

Dual Pathway Inhibition in Patients With mRCC: A Case Series From Kuwait Highlighting the Role of Avelumab and Axitinib. [PDF]

Case Rep Oncol Med
Ashour M, El-Shahat M.
europepmc   +1 more source

Theranostic nanoplatform for high‐performance dual‐modal magnetic resonance imaging‐guided therapy of orthotopic hepatocellular carcinoma

BMEMat, EarlyView.
This article introduces a biomimetic Mn‐doped polydopamine nanoplatform (HAMM NPs) coated with cancer cell membranes. It enables targeted hepatocellular carcinoma theranostics via T1/T2 dual‐mode magnetic resonance imaging and tumor microenvironment‐triggered sonodynamic therapy/chemodynamic therapy, achieving potent antitumor efficacy in subcutaneous ...
Jiayin Lin, Wenbo Chen, Xiuqi Hou, Kai Wang, Fan Liu, Ruling Zhang, Zhong Cao, Jian Zheng   +7 more
wiley   +1 more source

Correction to "Successful Treatment of Paranasal Sinus Metastasis From Renal Cell Carcinoma With Immune Checkpoint Inhibitors and Radiotherapy: A Case Report". [PDF]

IJU Case Rep
europepmc   +1 more source

Renal schwannoma appears on imaging as renal cell carcinoma: a case report. [PDF]

J Med Case Rep
Akdagcik Z, Bilgetekin I, Ozturk E, Demir N, Akturk S, Basar H.   +5 more
europepmc   +1 more source

The SWI/SNF protein PBRM1 restrains VHL-loss-driven clear cell renal cell carcinoma [PDF]

, 2017
et al,, Hsieh, James J
core   +2 more sources

Pazopanib in Locally Advanced or Metastatic Renal Cell Carcinoma: Results of a Randomized Phase III Trial

Journal of Clinical Oncology, 2010
C. Sternberg, I. Davis, J. Mardiak, C. Szczylik, Eunsik Lee, J. Wagstaff, C. Barrios, P. Salman, O. Gladkov, A. Kavina, J. Zarbá, Mei Chen, L. McCann, L. Pandite, D. Roychowdhury, R. Hawkins   +15 more
semanticscholar   +1 more source