Results 271 to 280 of about 1,472,301 (348)

The IQGAP1-Claudin4-JNK Signaling Axis as a Differential Biomarker in Renal Cell Carcinoma. [PDF]

open access: yesClin Transl Sci
Puente N   +8 more
europepmc   +1 more source

N6‐Methyladenosine (m6A) in Liver Disease: Pathogenic Mechanisms and Therapeutic Potential

open access: yesiNew Medicine, EarlyView.
ABSTRACT Accumulating evidence highlights the critical role of epigenetic modifications, particularly N6‐methyladenosine (m6A), in liver disease. As the most abundant RNA modification in eukaryotic cells, m6A is dynamically regulated by multicomponent m6A methyltransferases (e.g., METTL3 and METTL14), demethylases (FTO and ALKBH5), and m6A‐binding ...
Yingfen Chen   +6 more
wiley   +1 more source

Napabucasin transforms liver microenvironment and boosts immunotherapy efficacy by converting potential metastases into “hot” tumors

open access: yesInterdisciplinary Medicine, EarlyView.
Napabucasin reduces liver metastases by reprogramming the hepatic microenvironment. It induces hepatocyte secretion of CCL21 via c‐Fos activation, recruiting lymphocytes and converting “cold” metastases into immunologically “hot” tumors. This effect is liver‐specific and independent of cancer cells.
Qiongqiong Wang   +19 more
wiley   +1 more source

Ultrasound–triggered tumor‐selective nitric oxide release enhances tumor penetration of antibody–conjugated nanomedicine

open access: yesInterdisciplinary Medicine, EarlyView.
Ultrasound‐triggered nitric oxide release from S‐nitrosated hyaluronic acid (HA‐SNO) induces tumor vasodilation and disrupts the vascular barrier, potently enhancing the intratumoral penetration of antibody‐conjugated nanomedicines. Abstract The tumor vascular barrier restricts the penetration of antibody‐conjugated nanomedicine, severely limiting its ...
Xiaodong Wang   +4 more
wiley   +1 more source

Incidental renal pelvis and ureteral verrucous carcinoma: A case report and literature review. [PDF]

open access: yesMedicine (Baltimore)
Yang Z   +7 more
europepmc   +1 more source

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