Results 201 to 210 of about 5,058,773 (393)

Supplementary Table S6 from Association of MicroRNA Expression in Hepatocellular Carcinomas with Hepatitis Infection, Cirrhosis, and Patient Survival

, 2023
Jinmai Jiang, Yuriy Gusev, Ileana Aderca, Teresa A. Mettler, David M. Nagorney, Daniel J. Brackett, Lewis R. Roberts, Thomas D. Schmittgen   +7 more
openalex   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Supplementary Data from A Phase II Trial of Pembrolizumab and Vorinostat in Recurrent Metastatic Head and Neck Squamous Cell Carcinomas and Salivary Gland Cancer

, 2023
Cristina P. Rodriguez, Qian Wu, Jenna Voutsinas, Jonathan R. Fromm, Xiuyun Jiang, Venu G. Pillarisetty, Sylvia M. Lee, Rafael Santana-Dávila, Bernardo H. L. Goulart, Christina S. Baik, Laura Q.M. Chow, Keith D. Eaton, Renato Martins   +12 more
openalex   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Data Supplement from Squamous Cell Carcinoma of the Oral Tongue in Young Non-Smokers Is Genomically Similar to Tumors in Older Smokers

, 2023
Curtis R. Pickering, Jiexin Zhang, David M. Neskey, Mei Zhao, Samar A. Jasser, Jiping Wang, Alexandra Ward, C. Jillian Tsai, Marcus V. Ortega Alves, Jane H. Zhou, Jennifer Drummond, Adel K. El‐Naggar, Richard A. Gibbs, John N. Weinstein, David A. Wheeler, Jing Wang, Mitchell J. Frederick, Jeffrey N. Myers   +17 more
openalex   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Table S3 from Integrative Kinome Profiling Identifies mTORC1/2 Inhibition as Treatment Strategy in Ovarian Clear Cell Carcinoma

, 2023
Joseph J. Caumanns, Katrien Berns, G. Bea A. Wisman, Rudolf S.N. Fehrmann, Tushar Tomar, Harry Klip, Gert Jan Meersma, E. Marielle Hijmans, Annemiek M.C. Gennissen, Evelien W. Duiker, Desirée Weening, Hiroaki Itamochi, Roelof J.C. Kluin, Anna K.L. Reyners, Michael J. Birrer, Helga B. Salvesen, Ignace Vergote, Els Van Nieuwenhuysen, James D. Brenton, Elena Ioana Braicu, Jolanta Kupryjańczyk, Beata Śpiewankiewicz, Lorenza Mittempergher, René Bernards, Ate G.J. van der Zee, Steven de Jong   +25 more
openalex   +1 more source

Sorafenib in advanced clear-cell renal-cell carcinoma.

New England Journal of Medicine, 2007
B. Escudier, T. Eisen, W. Stadler, C. Szczylik, S. Oudard, M. Siebels, S. Négrier, C. Chevreau, E. Solska, A. Desai, F. Rolland, T. Demkow, Thomas E. Hutson, M. Gore, S. Freeman, B. Schwartz, M. Shan, R. Simantov, R. Bukowski   +18 more
semanticscholar   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Collision thyroid tumors: a case report of coexisting papillary and follicular carcinoma. [PDF]

J Surg Case Rep
Torselli-Valladares DE, Argueta V, Cordón CR, Peñalonzo MA.   +3 more
europepmc   +1 more source