Results 201 to 210 of about 1,711,715 (268)

A Non‐Canonical Role of SMAD4 in Regulating 3D Genome Architecture to Inhibit Lung Squamous Cell Carcinoma Development

Advanced Science, EarlyView.
SMAD4 is identified as a guardian of 3D genome architecture in lung squamous cell carcinoma. Loss of SMAD4 unleashes EP300 at chromatin loop anchors, strengthening enhancer–promoter looping and H3K27ac at the SOX2 locus to drive aberrant SOX2 activation and tumor cell proliferation.
Qian Tang, Chen Lian, Xinyan Han, Xuhan Zhang, Zihan Wang, Boyu Wang, Taoyu Zhu, Xinrui Lin, Xiaolei Wang, Yaping Xu, Manyu Xiao, Zijin Wang, Junming Li, Silin Chen, Yunze Wang, Yufei Liu, Songsong Li, Zuolin Shen, Xi Lu, Xueqi Han, Yilu Zhou, Mingyang Xiao, Jiayi Ran, Xiaoran Cao, Xinyi Xu, Hugo Sámano‐Sánchez, Alfredo Rodríguez, Lian Wang, Shuifang Chen, Zhanyu Xu, Shirong Zhang, Nuo Yang, Yong Tang, Jian Liu   +33 more
wiley   +1 more source

Editorial Comment on Rapid Systemic Progression After Ureteroscopic Holmium:YAG Laser Ablation for High-Grade Upper Tract Urothelial Carcinoma in a Solitary Kidney: A Case Report. [PDF]

IJU Case Rep
Kojima T.
europepmc   +1 more source

PTHrP-associated hypercalcemia in gynecologic malignancies: a scoping review. [PDF]

Arch Gynecol Obstet
Bohne SM, Wegwitz F, Kruse-Wieczorek J, Langer L, Gallwas J, Ströbel P, Hasanov MF.   +6 more
europepmc   +1 more source

Spindle Cell (Metaplastic) Carcinoma of the Breast Showing No Clinical Benefit with Pembrolizumab-Based Neoadjuvant Chemoimmunotherapy. [PDF]

Surg Case Rep
Yamada R, Kai K, Hidaka K, Yoshii D, Shirotani R, Takahashi T, Miyasato Y, Murakami S, Mikami Y, Komohara Y, Yamamoto Y.   +10 more
europepmc   +1 more source

Intermammary ulcer in an elderly woman. [PDF]

Int J Womens Dermatol
Martins F, Cardoso JC, Calvão J.
europepmc   +1 more source