Results 51 to 60 of about 3,245,969 (343)

Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma.

New England Journal of Medicine, 2007
BACKGROUND Interferon alfa is widely used for metastatic renal-cell carcinoma but has limited efficacy and tolerability. Temsirolimus, a specific inhibitor of the mammalian target of rapamycin kinase, may benefit patients with this disease.
G. Hudes, M. Carducci, P. Tomczak, J. Dutcher, R. Figlin, A. Kapoor, E. Starosławska, J. Sosman, D. McDermott, I. Bodrogi, Z. Kovačević, V. Lesovoy, I. Schmidt-Wolf, O. Barbarash, E. Gokmen, T. O'Toole, S. Lustgarten, L. Moore, R. Motzer   +18 more
semanticscholar   +1 more source

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source

CARCINOMA OF THE BREAST

Annals of Surgery, 1934
Abstract 1. 1. The histological grading of malignancies is not as generally accepted by pathologists as it is by surgeons. 2. 2. There are too many factors to be considered in such a grading to give any uniform opinion. 3. 3. Postoperative irradiation presents another disturbing factor in estimating any histological index. 4. 4.
openaire   +5 more sources

Outcomes of patients in nasopharyngeal adenoid cystic carcinoma in the IMRT era: a single-center experience

BMC Cancer
Objective Nasopharyngeal adenoid cystic carcinoma (NACC) is a rare malignancy with special biological features. Controversies exist regarding the treatment approach and prognostic factors in the IMRT era.
Wen-Bin Wu, Wu-Lin Cai, Ye-Hao Zou, Rui You, You-Ping Liu, Zhao-Di Yuan, Qiong Li, Wen-Chao Li, Zhi-Xuan Pi, Yu-Long Xie, Kai Wen, Ming-Yuan Chen, Rui Sun   +12 more
doaj   +1 more source

Avelumab plus Axitinib versus Sunitinib for Advanced Renal‐Cell Carcinoma

New England Journal of Medicine, 2019
BACKGROUND In a single‐group, phase 1b trial, avelumab plus axitinib resulted in objective responses in patients with advanced renal‐cell carcinoma. This phase 3 trial involving previously untreated patients with advanced renal‐cell carcinoma compared ...
R. Motzer, K. Penkov, J. Haanen, B. Rini, L. Albiges, M. Campbell, B. Venugopal, C. Kollmannsberger, S. Négrier, M. Uemura, J. Lee, A. Vasiliev, W. Miller, H. Gurney, M. Schmidinger, J. Larkin, M. Atkins, J. Bedke, B. Alekseev, Jing Wang, M. Mariani, P. Robbins, A. Chudnovsky, C. Fowst, S. Hariharan, B. Huang, A. di Pietro, T. Choueiri   +27 more
semanticscholar   +1 more source

Goodbye flat lymphoma biology

FEBS Letters, EarlyView.
Three‐dimensional (3D) biological systems have become key tools in lymphoma research, offering reliable in vitro and ex vivo platforms to explore pathogenesis and support precision medicine. This review highlights current 3D non‐Hodgkin lymphoma models, detailing their features, advantages, and limitations, and provides a broad perspective on future ...
Carla Faria, Cèlia Dobaño‐López, Patricia Pérez‐Galán, Christine Bezombes   +3 more
wiley   +1 more source

Screening high-risk individuals for primary gastric carcinoma: evaluating overall survival probability score in the presence and absence of lymphatic metastasis post-gastrectomy

World Journal of Surgical Oncology
Objective The aim of this study was to develop and validate prognostic models for predicting overall survival in individuals with gastric carcinoma, specifically focusing on both negative and positive lymphatic metastasis.
Wenqing Qu, Ling Li, Jinfeng Ma, Yifan Li   +3 more
doaj   +1 more source

Stratification of Candidates for Induction Chemotherapy in Stage III-IV Nasopharyngeal Carcinoma: A Large Cohort Study Based on a Comprehensive Prognostic Model

Frontiers in Oncology, 2020
Objective: To establish a prognostic index (PI) for patients with stage III-IV nasopharyngeal carcinoma (NPC) patients to personalize recommendations for induction chemotherapy (IC) before intensity-modulated radiotherapy (IMRT).Patients and Methods ...
Xue-Song Sun, Xue-Song Sun, Bei-Bei Xiao, Bei-Bei Xiao, Zi-Jian Lu, Zi-Jian Lu, Sai-Lan Liu, Sai-Lan Liu, Qiu-Yan Chen, Qiu-Yan Chen, Li Yuan, Lin-Quan Tang, Lin-Quan Tang, Hai-Qiang Mai, Hai-Qiang Mai   +14 more
doaj   +1 more source

Tumor angiogenesis and metastasis--correlation in invasive breast carcinoma.

New England Journal of Medicine, 1991
BACKGROUND Experimental evidence suggests that the growth of a tumor beyond a certain size requires angiogenesis, which may also permit metastasis.
N. Weidner, J. Semple, W. Welch, J. Folkman   +3 more
semanticscholar   +1 more source

ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling

FEBS Letters, EarlyView.
In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li, Gerard van der Zon, Peter ten Dijke, Tong Shen   +3 more
wiley   +1 more source