Results 51 to 60 of about 2,350,360 (261)

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

LIHNCS - Lugol's iodine in head and neck cancer surgery : a multicentre, randomised controlled trial assessing the effectiveness of Lugol’s iodine to assist excision of moderate dysplasia, severe dysplasia and carcinoma in situ at mucosal resection margins of oral and oropharyngeal squamous cell carcinoma : study protocol for a randomised controlled trial [PDF]

, 2013
Background: Oral cavity and oropharynx cancer are increasing in incidence worldwide but survival outcomes have not significantly improved over the last three decades. The presence of dysplasia or carcinoma in situ at surgical margins following resection
McMahon, Jeremy, Mehanna, Hisham M., McConkey, Christopher C., Hisham Mehanna, Sutton, David N., Dunn, Janet, Cymerman, James A, McCaul, James A, Sutton, David N, Shaw, Richard, James A McCaul, Dunn, Janet A., McCaul, James A., Jeremy McMahon, David N Sutton, Cymerman, James A., Hislop, Stuart, McConkey, Chris, James A Cymerman, Stuart Hislop, Richard Shaw, Mehanna, Hisham; id_orcid, Chris McConkey, Janet Dunn   +23 more
core   +1 more source

Effect and safety of immunotherapy among elder patients (age ≥ 65) with recurrent or metastatic nasopharyngeal carcinoma

BMC Cancer
Background The use of immune checkpoint inhibitors (ICIs) combined with chemotherapy constitutes the first-line treatment for recurrent or metastatic nasopharyngeal carcinoma (RM-NPC).
Rui-Ling Xie, Wu-Lin Cai, Yan-Feng Ouyang, Ye-Hao Zou, Rui Sun   +4 more
doaj   +1 more source

Stratification of Candidates for Induction Chemotherapy in Stage III-IV Nasopharyngeal Carcinoma: A Large Cohort Study Based on a Comprehensive Prognostic Model

Frontiers in Oncology, 2020
Objective: To establish a prognostic index (PI) for patients with stage III-IV nasopharyngeal carcinoma (NPC) patients to personalize recommendations for induction chemotherapy (IC) before intensity-modulated radiotherapy (IMRT).Patients and Methods ...
Xue-Song Sun, Xue-Song Sun, Bei-Bei Xiao, Bei-Bei Xiao, Zi-Jian Lu, Zi-Jian Lu, Sai-Lan Liu, Sai-Lan Liu, Qiu-Yan Chen, Qiu-Yan Chen, Li Yuan, Lin-Quan Tang, Lin-Quan Tang, Hai-Qiang Mai, Hai-Qiang Mai   +14 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

The epidemiology and survival of extrapulmonary small cell carcinoma in South East England, 1970-2004. [PDF]

, 2009
BACKGROUND: Extrapulmonary small cell carcinoma (EPSCC) is a rare cancer and few studies describe its epidemiology. Our objectives were to compare the incidence and survival of EPSCC in South East England with small cell carcinoma of the lung (SCLC), to ...
Jack, Ruth H, Jack Ruth H, Elizabeth A Davies, Jack, Ruth H., Wong Yien, Davies, Elizabeth A.; id_orcid, Henrik Møller, Mak, Vivian, Møller Henrik, Vivian Mak, Wong, Yien Ning S., Mak Vivian, Henrik, Moller; id_orcid, Yien Ning S Wong, Ruth H Jack, Davies Elizabeth A, Henrik, Møller, Davies, Elizabeth A, Wong, Yien Ning S   +18 more
core   +2 more sources

Application of Immunohistochemistry in Papillary Thyroid Carcinoma

, 2022
Immunohistochemistry (IHC) is an economic and precise method to localize the presence of specific protein at cellular level in tissue. Although many papillary thyroid carcinomas do not require IHC to render a diagnosis, there are certain scenarios in ...
Lam, AK, Lee, KTW
core   +1 more source

Predictive value of nasopharyngeal microbiota for necrosis after re-irradiation in recurrent nasopharyngeal carcinoma

BMC Cancer
Background Post-radiation nasopharyngeal necrosis (PRNN) is a severe complication following re-irradiation in patients with recurrent nasopharyngeal carcinoma (NPC).
Kai Wen, Ze-Rong Huang, Yong-Long Liu, Wen-Bin Wu, Zi-Han Qin, Yan-Feng Ouyang, Xiong Zou, Rui You, You-Ping Liu, Ming-Yuan Chen, Yi-Jun Hua   +10 more
doaj   +1 more source

Intensive Local Radiotherapy Is Associated With Better Local Control and Prolonged Survival in Bone-Metastatic Nasopharyngeal Carcinoma Patients

Frontiers in Oncology, 2020
Objective: To compare the survival outcomes brought by different radiation dose schedules to bone lesions and different chemotherapy regimens in bone metastatic nasopharyngeal carcinoma (NPC).Background: The current treatment strategy for bone metastatic
Xiao-Yun Li, Xiao-Yun Li, Guo-Dong Jia, Guo-Dong Jia, Xue-Song Sun, Xue-Song Sun, Shan-Shan Guo, Shan-Shan Guo, Li-Ting Liu, Li-Ting Liu, Sai-Lan Liu, Sai-Lan Liu, Jin-Jie Yan, Jin-Jie Yan, Dong-Hua Luo, Dong-Hua Luo, Rui Sun, Rui Sun, Ling Guo, Ling Guo, Hao-Yuan Mo, Hao-Yuan Mo, Lin-Quan Tang, Lin-Quan Tang, Qiu-Yan Chen, Qiu-Yan Chen, Hai-Qiang Mai, Hai-Qiang Mai   +27 more
doaj   +1 more source

Limited recurrence distance of glioblastoma under modern radiotherapy era

BMC Cancer, 2021
Background The optimal treatment volume for Glioblastoma multiforme (GBM) is still a subject of debate worldwide. The current study was aimed to determine the distances between recurring tumors and the edge of primary lesions, and thereby provide ...
Ziwei Tu, Huifen Xiong, Yang Qiu, Guoqing Li, Li Wang, Shiyi Peng   +5 more
doaj   +1 more source