Results 21 to 30 of about 1,179,909 (205)

Upregulation of Spinal miR-155-5p Contributes to Mechanical Hyperalgesia by Promoting Inflammatory Activation of Microglia in Bone Cancer Pain Rats

Life, 2022
Bone cancer pain (BCP) seriously deteriorates the life quality of patients, but its underlying mechanism is still unclear. Spinal microRNAs might contribute to the development of BCP and the role of microglial activation is controversial.
Yanping Jian, Zongbin Song, Zhuofeng Ding, Jian Wang, Ruike Wang, Xinran Hou   +5 more
doaj   +1 more source

Characterisation of Walker 256 breast carcinoma cells from two tumour cell banks as assessed using two models of secondary brain tumours

Cancer Cell International, 2013
Background Metastatic brain tumours are a common end stage of breast cancer progression, with significant associated morbidity and high mortality.
Lewis Kate M, Harford-Wright Elizabeth, Vink Robert, Ghabriel Mounir N   +3 more
doaj   +1 more source

Overexpression of GDNF in Spinal Cord Attenuates Morphine Analgesic Tolerance in Rats with Bone Cancer Pain

Brain Sciences, 2022
Bone cancer pain (BCP) is one of the typical and distressing symptoms in cancer patients. Morphine is a widely used analgesic drug for BCP; however, long-term morphine administration will lead to analgesic tolerance.
Wei Xu, Zhuofeng Ding, Zongbin Song, Jian Wang, Jie Zhang, Wangyuan Zou   +5 more
doaj   +1 more source

Influence of lodgement site on the proliferation of metastases of Walker 256 carcinoma in the rat [PDF]

British Journal of Cancer, 1978
The growth of s.c. Walker 256 carcinoma was found to be independent of secondary growths induced by i.v. injection. Tumour cells injected i.v. lodged mainly in the lungs, with small clusters of cells in the lymph nodes. The rate of cellular proliferation of these secondary growths of Walker carcinoma was significantly higher than that observed in the s.
D, Bellamy, S M, Hinsull
openaire   +2 more sources

Experimental model of ultrasound thermotherapy in rats inoculated with Walker-236 tumor Modelo experimental de termoterapia ultrassônica em ratos inoculados com tumor de Walker-236

Acta Cirúrgica Brasileira, 2011
PURPOSE: To develop a model to evaluate the effects of focal pulsed ultrasound (US) waves as a source of heat for treatment of murine subcutaneous implanted Walker tumor. METHODS: An experimental, controlled, comparative study was conducted.
José Antonio Carlos Otaviano David Morano, Naylana Cordeiro, Sergio Botelho Guimarães, Francisco Vagnaldo Fechine Jamacaru, Manoel Odorico de Moraes Filho   +4 more
doaj   +1 more source

Robust spinal neuroinflammation mediates mechanical allodynia in Walker 256 induced bone cancer rats

Molecular Brain, 2012
It has been reported that remarkable and sustained activation of astrocytes and/or microglia occurs in cancer induced pain (CIP), which is different from neuropathic and inflammatory pain.
Mao-Ying Qi-Liang, Wang Xiao-Wei, Yang Chang-Jiang, Li Xiu, Mi Wen-Li, Wu Gen-Cheng, Wang Yan-Qing   +6 more
doaj   +1 more source

Hyaluronic Acid Content of the Interstitial Fluid of Walker Carcinoma 256

Experimental Biology and Medicine, 1970
SummaryThe interstitial fluid of Walker carcinoma transplanted into Sprague-Dawley rats was sampled in vivo and compared with the interstitial fluid of the subcutaneous area where the tumor was tra...
B, Fiszer-Szafarz, P M, Gullino
openaire   +2 more sources

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

British Journal of Pharmacology, EarlyView.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown, Alan Armstrong, David J. Mann   +2 more
wiley   +1 more source

Chemokine receptor CXCR4 activates the RhoA/ROCK2 pathway in spinal neurons that induces bone cancer pain

Molecular Pain, 2020
Background Chemokine receptor CXCR4 has been found to be associated with spinal neuron and glial cell activation during bone cancer pain. However, the underlying mechanism remains unknown.
Heng Xu, Chong Peng, Xue-Tai Chen, Ying-Ying Yao, Li-Ping Chen, Qin Yin, Wen Shen   +6 more
doaj   +1 more source

Hypersensitivity to Warfarin in Rats with Walker 256 Carcinoma

Experimental Biology and Medicine, 1982
AbstractWalker 256 carcinoma cells were injected subcutaneously into rats that were then given warfarin intravenously. Depression of prothrombin and factors VII, IX, and X levels was much greater than in control rats given the same doses of warfarin. A somewhat similar hypersensitivity accompanied treatment of normal rats with subcutaneous injections ...
openaire   +2 more sources