Results 41 to 50 of about 1,179,909 (205)

Update of the risk assessment on emerging and novel brominated flame retardants in food

EFSA Journal, Volume 24, Issue 7, July 2026.
Abstract The European Commission asked EFSA to update its 2012 risk assessment on Emerging and Novel brominated flame retardants (BFRs) in food. Since the previous Opinion, further information was collected for a total of 27 BFRs. The CONTAM Panel concluded that TDBPP, DBPNG and TBNPA are considered genotoxic and carcinogenic.
EFSA Panel on Contaminants in the Food Chain (CONTAM), Helle Katrine Knutsen, Agneta Åkesson, Vasileios Bampidis, Margherita Bignami, Laurent Bodin, James Kevin Chipman, Gisela Degen, Antonio Hernández‐Jerez, Tim Hofer, Christer Hogstrand, Stefano Landi, Jean‐Charles Leblanc, Kyriaki Machera, Evangelia Ntzani, Isabelle P. Oswald, Guido Rychen, Salomon Sand, Katharina Vejdovszky, Barbara Viviani, Emilio Benfenati, Diane Benford, Andy Hart, Martin Rose, Henri Schroeder, Christiane Vleminckx, Martine Vrijheid, Edoardo Carnesecchi, Violetta Costanzo, Andrea Gissi, Eirini Kouloura, Luisa Ramos Bordajandi, Francesca Riolo, Christer Hogstrand   +33 more
wiley   +1 more source

Optimization and In Vivo Profiling of a Refined Rat Model of Walker 256 Breast Cancer Cell-Induced Bone Pain Using Behavioral, Radiological, Histological, Immunohistochemical and Pharmacological Methods

Frontiers in Pharmacology, 2017
In the majority of patients with advanced breast cancer, there is metastatic spread to bones resulting in pain. Clinically available drug treatments for alleviation of breast cancer-induced bone pain (BCIBP) often produce inadequate pain relief due to ...
Priyank Shenoy, Priyank Shenoy, Andy Kuo, Irina Vetter, Irina Vetter, Maree T. Smith, Maree T. Smith   +6 more
doaj   +1 more source

Biosensors for Biotoxins Detection and Monitoring

Advanced Sensor Research, Volume 5, Issue 6, June 2026.
This review examines state‐of‐the‐art biosensing platforms for biotoxin detection, including antibody‐, aptamer‐, CRISPR‐, nanopore‐, whole cells‐ and MIP‐based sensors. It highlights advances in ultra‐sensitive detection, real‐matrix validation in food and water, and multiplexed analysis, and discusses how the integration with machine learning ...
Alissa Agerova, Juan Francisco Bada Juarez, Matteo Dal Peraro   +2 more
wiley   +1 more source

Activation of c-jun N-terminal kinase in spinal cord contributes to breast cancer induced bone pain in rats

Molecular Brain, 2012
Background The most frequent pain in patients with metastatic breast and prostate cancer is bone pain, which can be severe and difficult to treat. The mechanisms underlying this pain remain unclear.
Wang Xiao-Wei, Hu Shan, Mao-Ying Qi-Liang, Li Qian, Yang Chang-Jiang, Zhang Hui, Mi Wen-Li, Wu Gen-Cheng, Wang Yan-Qing   +8 more
doaj   +1 more source

Cold atmospheric plasma‐mediated tumor microenvironment remodeling for cancer treatment

BMEMat, Volume 4, Issue 2, June 2026.
Schematic presentation of CAP‐mediated TME remodeling. This review summarizes recent efforts in cold atmospheric plasma (CAP) application in cancer treatment, highlighting the anticancer potential of CAP, molecular mechanisms, and future perspectives for further improvement and clinical translation.
Israr Khan, Qiujie Fang, Cao Fei, Ziyuan Wang, Zhaowei Chen, Guojun Chen, Zhiming Xu, Shu Xu, Zhitong Chen   +8 more
wiley   +1 more source

Red propolis and L-lysine on angiogenesis and tumor growth in a new model of hamster cheek pouch inoculated with Walker 256 tumor cells

Einstein (São Paulo)
Objective: To evaluate the effect of red propolis and L-lysine on angiogenesis and tumor growth in a new model of hamster cheek pouch inoculated with Walker 256 tumor cells.
Camila de Carvalho Juanes, Susana Moreira de Souza, Vanessa Nogueira Lages Braga, Francisco Stefânio Barreto, Gisele Rocha Aguiar, Kleison Douglas Gomes Pimentel, Francisco Vagnaldo Fechine, Conceição Aparecida Dornelas   +7 more
doaj   +1 more source

Alleviating Mechanical Allodynia and Modulating Cellular Immunity Contribute to Electroacupuncture’s Dual Effect on Bone Cancer Pain

Integrative Cancer Therapies, 2018
Hypothesis: Electroacupuncture (EA) has been used as an alternative analgesic therapy for hundreds of years, yet its analgesic potency and therapeutic advantage against bone cancer pain (BCP) in comparison with morphine remains unclear.
Yi Liang PhD, Jun-Ying Du PhD, Jun-Fan Fang PhD, Ruo-Yi Fang MD, Jie Zhou MD, Xiao-Mei Shao PhD, Yong-Liang Jiang PhD, Yi-Tian Chen MD, Jian-Qiao Fang PhD   +8 more
doaj   +1 more source

Transcriptomic analysis of long noncoding RNAs and mRNAs expression profiles in the spinal cord of bone cancer pain rats

Molecular Brain, 2020
Bone cancer pain (BCP) is one of the most common types of chronic cancer pain and its pathogenesis has not been fully understood. Long non-coding RNAs (lncRNAs) are new promising targets in the field of pain research, however, their involvements in BCP ...
Xinran Hou, Yingqi Weng, Qulian Guo, Zhuofeng Ding, Jian Wang, Jiajia Dai, Anqi Wei, Zongbin Song   +7 more
doaj   +1 more source

Impact of the acidic environment on gene expression and functional parameters of tumors in vitro and in vivo

Journal of Experimental & Clinical Cancer Research, 2021
Background The low extracellular pH (pHe) of tumors resulting from glycolytic metabolism is a stress factor for the cells independent from concomitant hypoxia.
Mandy Rauschner, Luisa Lange, Thea Hüsing, Sarah Reime, Alexander Nolze, Marcel Maschek, Oliver Thews, Anne Riemann   +7 more
doaj   +1 more source

Antitumor activity of methotrexate‐albumin conjugates in rats bearing a Walker‐256 carcinoma [PDF]

International Journal of Cancer, 1998
We have recently reported that albumin accumulates in solid tumors and serves there as a source of nitrogen and energy. Methotrexate-albumin conjugates [MTX(I)-RSA] derivatized at a molar ratio of 1:1 differ favorably from original MTX in terms of plasma presence and tumor uptake.
A, Wunder, G, Stehle, H H, Schrenk, G, Hartung, D L, Heene, W, Maier-Borst, H, Sinn   +6 more
openaire   +2 more sources