Results 41 to 50 of about 2,761,482 (311)

Crosstalk between gut microbiota and tumor: tumors could cause gut dysbiosis and metabolic imbalance

Molecular Oncology, EarlyView.
In this research, we analyzed the relationship between gut microbiota and tumor. We discovered that both subcutaneous and metastatic tumors would alter the composition and metabolic function of gut microbiota. Meanwhile, fecal microbiota transplantation also indicated the anti‐tumor role of the gut microbiota, revealing the crosstalk between tumor and ...
Siyuan Zhang, Haimei Wen, Ying Chen, Jingya Ning, Di Hu, Yujiao Dong, Chenyu Yao, Bo Yuan, Shuanying Yang   +8 more
wiley   +1 more source

Advances in Breast MRI in the Setting of Ductal Carcinoma In Situ.

Seminars in roentgenology, 2018
Ductal carcinoma in situ (DCIS) of the breast is a pre-invasive breast malignancy with controversial clinical relevance and management. These lesions have increased in incidence with breast cancer screening programs and are associated with increasingly ...
N. Amornsiripanitch, D. Lam, H. Rahbar
semanticscholar   +1 more source

Low grade Ductal Carcinoma in situ (DCIS): how best to describe it? [PDF]

, 2014
BACKGROUND: In the absence of definitive data about the natural history of DCIS the appropriateness of describing DCIS as cancer is controversial. METHODS: We conducted a survey amongst British Breast Group (BBG) members, to determine which descriptions ...
Adele Francis, Daniel Rea, Esserman, Fallowfield, Flanders, Galimberti, Independent, Lesley Fallowfield, Lucy Matthews, NIH Consensus and State of the Science Statements, Prinjha, Prinjha, Valerie Jenkins, Wallis   +13 more
core   +1 more source

The PTTG1/VASP axis promotes oral squamous cell carcinoma metastasis by modulating focal adhesion and actin filaments

Molecular Oncology, EarlyView.
VASP was found to be overexpressed in metastatic oral squamous cell carcinoma (OSCC) tissues. Notably, PTTG1‐ and VASP‐deficient OSCC cells demonstrated suppressed metastatic properties by disrupting the interaction between the cytoskeleton and focal adhesion (FAs) in the filopodia region.
Suyeon Park, Sang Shin Lee, Shihyun Kim, Yeonjun Lee, Gyeonwon Park, Jung Oh Kim, Jongho Choi   +6 more
wiley   +1 more source

Paradigm Shift toward Reducing Overtreatment of Ductal Carcinoma In Situ of Breast

Frontiers in Oncology, 2017
The prevalence of ductal carcinoma in situ (DCIS) of the breast has increased substantially after the introduction of breast cancer screening programs, although the clinical effects of early DCIS detection and treatment remain unclear.
Y. Sagara, W. Julia, M. Golshan, M. Toi
semanticscholar   +1 more source

INVESTIGATING INVASION IN DUCTAL CARCINOMA IN SITU WITH TOPOGRAPHICAL SINGLE CELL GENOME SEQUENCING [PDF]

, 2018
Synchronous Ductal Carcinoma in situ (DCIS-IDC) is an early stage breast cancer invasion in which it is possible to delineate genomic evolution during invasion because of the presence of both in situ and invasive regions within the same sample.
Casasent, Anna, Casasent, Anna
core   +1 more source

Polyfunctional CD8+CD226+RUNX2hi effector T cells are diminished in advanced stages of chronic lymphocytic leukemia

Molecular Oncology, EarlyView.
CD226+CD8+ T cells express elevated levels of RUNX2, exhibit higher proliferation capacity, cytokines and cytolytic molecules expression, and migratory capacity. In contrast, CD226−CD8+ T cells display an exhausted phenotype associated with the increased expression of co‐inhibitory receptors and impaired effector functions.
Maryam Rezaeifar, Shima Shahbaz, Anthea C. Peters, Spencer B. Gibson, Shokrollah Elahi   +4 more
wiley   +1 more source

Rapid and Scalable Halosulfonylation of Strain‐Release Reagents**

Angewandte Chemie, Volume 135, Issue 3, January 16, 2023., 2023
A one‐pot halosulfonylation of strained hydrocarbons is described that proceeds under practical, scalable and mild conditions. Sulfonyl halides featuring aryl, heteroaryl and alkyl substituents are generated in situ from sulfinate salts and convenient halogen atom sources. This chemistry enables the synthesis of an array of halogen/sulfonyl‐substituted
Helena D. Pickford, Vasyl Ripenko, Ryan E. McNamee, Serhii Holovchuk, Amber L. Thompson, Russell C. Smith, Pavel K. Mykhailiuk, Edward A. Anderson   +7 more
wiley   +2 more sources

A novel therapy for breast cancer: implications for treatment access [PDF]

, 2019
In 2016, there were 250,000 new cases of invasive cancer and 60,000 of ductal carcinoma in situ. Mammograms are used to screen for cases of disease, but the literature shows that mammograms are highly dependent on patient characteristics and do not ...
Cespedes-Gomez, Omar
core  

Targeting PRAME directly or via EZH2 inhibition overcomes retinoid resistance and represents a novel therapy for keratinocyte carcinoma

Molecular Oncology, EarlyView.
The study evaluated the function and therapeutic implications of PRAME in basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). The findings demonstrate that PRAME impairs keratinocyte differentiation pathways. Furthermore, PRAME impairs anticancer response to retinoid compounds in BCC and SCC cells.
Brandon Ramchatesingh, Amelia Martinez Villarreal, Philippe Lefrançois, Jennifer Gantchev, Sriraam Sivachandran, Samy Abou Setah, Ivan V. Litvinov   +6 more
wiley   +1 more source