Results 51 to 60 of about 206,955 (264)

Erythroplasia of Queyrat

Clinics and Practice, 2012
A 58-year-old Caucasian male presented to the urology clinic reporting an approximate one-year history of a persistent irritating, slowly progressive, glans penis redness. Biopsy revealed penile squamous cell carcinoma in situ.
Deirdre Mary Fanning, Hugh Flood
doaj   +1 more source

Protein Corona Formation on Soft Nanocarriers Under Biomimetic Circulatory Flow

Advanced Materials Interfaces, EarlyView.
A biomimetic venous circulation system is developed to study protein corona formation on soft nanocarriers under physiological shear. Liposomes, PLGA nanoparticles, and lipid‐polymer hybrid nanoparticles acquire largely shared but material‐dependent protein coronas that alter surface properties and suppress cellular uptake, highlighting the importance ...
Anamarija Nikoletić, Dominik Simon Müller, Timon Flathmann, Jakob Steuer, Evangelos Natsaridis, Chiara Candino, Abdullah Kahraman, Oya Tagit   +7 more
wiley   +1 more source

Spheroid‐On‐A‐Drop: A Modular Droplet Microfluidics Platform

Advanced Materials Technologies, EarlyView.
The proposed Spheroid‐on‐a‐Drop platform represents a reproducible and tunable platform for the fabrication of biocompatible GelMA‐based microgels, able to support controlled 3D tumor spheroid culture. Its precise control over droplet dynamics and cell distribution paves the way for advanced applications in tissue modeling, drug screening, and ...
A. Fergola, V. Vighetto, G. Mesiano, A. Cosola, S. L. Marasso, M. Cocuzza, C. F. Pirri, L. Napione, F. Frascella   +8 more
wiley   +1 more source

Stromal‐Derived IL‐8 Promotes M2 Macrophage Polarization via the RhoA/MRTF‐A/SRF Transcriptional Axis to Impair CD8+ T Cell Cytotoxicity in Lung Cancer

Advanced Science, EarlyView.
In the recondite pulmonary neoplastic milieu, DESMIN+ cancer‐associated fibroblasts function as the paramount stromal source of IL‐8, precipitating a deleterious immunological metamorphosis by engaging CXCR2 receptors on the myeloid lineage. This paracrine stimulus triggers a mechanotransduction cascade characterized by RhoA‐dependent actin ...
Xuyu Gu, Qiyu Fang, Jia Yu, Ting Yu, Huashan Shi, Kaiqi Jin, Lei Jiang, Wentian Zhang   +7 more
wiley   +1 more source

TSPYL5 Promotes Triple‐Negative Breast Cancer Metastasis by Antagonizing USP10‐Mediated PTEN Stabilization to Unleash a ZEB1‐Dependent EMT Program

Advanced Science, EarlyView.
The hyperactivation of PI3K/AKT signaling in PTEN wild‐type triple‐negative breast cancer represents a clinical paradox. We delineate a novel post‐translational regulatory axis wherein the oncogene TSPYL5 competitively antagonizes the deubiquitinase USP10.
Jiaying Shi, Ming Yi, Shengyu Xie, Zhaokun Wang, Xinyue Zhang, Yangwei Zhang, Rui Tang, Yuan Yang, Yunqiang Liu   +8 more
wiley   +1 more source

Bifidobacterium Pseudolongum‐Derived Inosine Mitigates Polystyrene Nanoplastics‐Induced Hepatic Injury by Inhibiting the Polarization of M1 Macrophages

Advanced Science, EarlyView.
Probiotic B.p colonization elevated gut‐derived inosine level in the liver, while elevated inosine activated A2AR and subsequently blocked NPs‐induced polarization of M1 macrophages by repressing the miR155/SOCS1/NF‐κB pathway. This reduced the release of inflammatory cytokines and thereby, mitigated NPs‐induced hepatic injury.
Kaikai Zhang, Yuchuan Chen, Jiayuan Wan, Jianzheng Yang, Lijian Chen, Qingyuan Li, Anding Zhou, Nian Zhou, Jiuyang Ding, Qi Wang, Jian Sun   +10 more
wiley   +1 more source

Tumor phylodes en adolescentes

Revista Electrónica Dr. Zoilo E. Marinello Vidaurreta, 2016
El tumor phylodes es una neoplasia fibroepitelial rara, constituye del 0,3 al 0,9 % de los tumores de mama y del 2 al 3 % de los tumores fibroepiteliales de la mama, se puede ver a cualquier edad; la mayoría son benignos pero hasta un 30 % pueden ...
Jaime Landell Cruz, Clara Adys Martínez Velázquez   +1 more
doaj  

p53-protein over-expression and gene mutational of oral carcinoma in-situ

Dental Journal, 2007
We had been reported histological types of oral carcinoma in-situ (oral CIS), such as basaloid, verrucous, and acanthothic/ atrophic types. We considered that they have different histological appearance influenced by molecular behavior. To understand the
Mei Syafriadi, Takashi Saku
doaj   +1 more source

Astrocytic Phenotypic Switching in Posterior Piriform Cortex Orchestrates Bone Cancer Pain–Depression Comorbidity via Purinergic–Noradrenergic Signaling

Advanced Science, EarlyView.
Bone cancer pain and depression share a common origin: astrocytic A2‐to‐A1 transition in the posterior piriform cortex. This phenotypic shift disrupts the ATP–adenosine–A2AR–norepinephrine axis, simultaneously driving nociceptive and affective dysfunction.
Jiang‐Ping Liu, Jun‐Han Zhang, Zhi‐Xuan Tan, Wei‐Bing Yan, Ya‐Ru Yuan, Yao Liu, Bing‐Di Wei, Meng‐Qi Ding, Zhuo‐Min Fu, Ying Liu, An‐Qi Wang, Lin Ma, Yong‐Hong Li, Er‐Qing Chai, Chao‐Jun Wei   +14 more
wiley   +1 more source

Association of initial transurethral resection staging on survival in radical cystectomy patients [PDF]

Investigative and Clinical Urology
Purpose: Muscle-invasive bladder cancer (MIBC) is highly aggressive and presents complex treatment challenges. This study aimed to determine if the stage found during the initial transurethral resection of bladder tumor (TURBT) significantly impacts the ...
Joongwon Choi, Wan Song, Jong Kil Nam, Bumjin Lim, Wook Nam, Jong Jin Oh, Seung-hwan Jeong, Seok Ho Kang, Tae-Hwan Kim, Ji Eun Heo, Won Sik Ham, Geehyun Song, Ho Kyung Seo, Chung Un Lee, Yong Seong Lee, Se Young Choi , Kyung Hwan Kim, Byong Chang Jeong   +17 more
doaj   +1 more source