Results 61 to 70 of about 17,121 (220)

A retrospective study evaluating the effect of trastuzumab addition to carboplatin/paclitaxel on overall survival in patients with advanced-stage HER2/neu-overexpressing uterine serous carcinoma or carcinosarcoma

BMC Medicine
Background Uterine serous carcinoma and carcinosarcoma are aggressive forms of endometrial cancer with poor survival outcomes. Trastuzumab, a human epidermal growth factor receptor-2 (HER2)-directed monoclonal antibody, has demonstrated tumoricidal ...
Ting-Fang Lu, Lou Sun, Yu-Hsiang Shih, Yen-Fu Chen, Chun-Ting Fan, Shao-Jing Wang, Shih-Tien Hsu, Chih-Ku Liu, Sheau-Feng Hwang, Chien-Hsing Lu   +9 more
doaj   +1 more source

Coordinated regulation of PIEZO2 by alternative splicing, post‐translational modification, membrane trafficking and protein partners

The Journal of Physiology, EarlyView.
Abstract figure legend Regulatory mechanisms such as alternative splicing, post‐translational modification, membrane trafficking, and protein interactions control channel gating, membrane abundance, and overall activity of PIEZO2. Proper regulation supports PIEZO2‐dependent proprioceptive, somatosensory, nociceptive, pruriceptive and interoceptive ...
Eunice I. Oribamise, Qinglu Li, Mary G. Garry   +2 more
wiley   +1 more source

Prostatic Carcinosarcoma with Lung Metastases [PDF]

, 2013
Carcinosarcoma of the prostate is an uncommon malignancy with poor long-term prognosis. The cancer is typically discovered at an advanced stage, and with less than 100 reported cases, there is limited literature concerning treatment options.
David J. Kang, Armando Armas, Stefanie R. Furlan   +2 more
core   +1 more source

Cancer heterogeneity explored through immune cell deconvolution of the tumor microenvironment

Quantitative Biology, Volume 14, Issue 3, September 2026.
Abstract Cancer is a highly heterogeneous disease, characterized by significant variability across multiple dimensions. This diversity has been extensively studied from various perspectives. In this study, we aim to examine cancer heterogeneity through the lens of immune cell composition within the tumor microenvironment.
Limin Jiang, Chung‐I Li, Rui Xin, Jijun Tang, Yan Guo   +4 more
wiley   +1 more source

A Case of Significant Response to Olaparib in a Patient with Primary Peritoneal Carcinosarcoma Diagnosed by Laparoscopic Surgery

Case Reports in Obstetrics and Gynecology, 2020
Primary peritoneal carcinosarcomas which arise from extragenital locations are extremely rare. Carinosarcomas contain both carcinomatous and sarcomatous elements and can be mainly detected in the female genital tract.
Satoshi Nagamata, Yukiko Nakasuji, Keitaro Yamanaka, Maho Azumi, Keiichi Washio, Maho Shimizu, Ryosuke Takahashi, Kazuyo Matsumoto, Yuka Murata, Kaho Suzuki, Masashi Deguchi, Hideto Yamada, Yoshito Terai   +12 more
doaj   +1 more source

Bladder carcinosarcoma treated by cystectomy and adjuvant chemotherapy with good outcomes: a case report

Journal of Medical Case Reports, 2023
Background Primary carcinosarcoma of the bladder is a rare and highly aggressive tumor, representing less than 1% of all bladder neoplasms. There is no specific treatment guideline has for carcinosarcoma of the bladder, and majority of published patients
Fadila Kouhen, Zineb Dahbi, Mohammed Afif, Meriem Chihabeddine, Nadia Errafiy, Kenza Oqbani, Youssef Omor, Amal Elhossini   +7 more
doaj   +1 more source

TCF/LEF family transcription factors: Molecular landscape and prognostic scoring in pan‐cancer

Clinical and Translational Discovery, Volume 6, Issue 4, August 2026.
This study provides a comprehensive molecular landscape of TCF/LEF family transcription factors across 33 cancer types. We developed a TCF/LEF‐based prognostic score that correlates with immune infiltration, metabolic reprogramming and drug sensitivity, offering a robust transcriptomic signature for predicting patient survival and therapeutic response.
Zhengjun Yang, D. Q. Cai, Zhen Zhao, Zhixiang Jian, Mude Shi, Yajin Chen, Jueming Chen, Chunhua Qu, Diankui Cai   +8 more
wiley   +1 more source

Gastric carcinosarcoma

, 2016
Gastric carcinosarcoma is an uncommon biphasic malignant tumor. We report the case of 59-year-old man with a history of melena and dizziness. Endoscopic findings showed a fungating mass that originated from the posterior wall of upper body. Radical total
Jeong-Hwan Kim, Pyeong-Su Kim, Ho-Yoon Bang, Dong-Seok Han, Min-Young Park, So-Young Yoon, So-Dug Lim   +6 more
core   +1 more source

Mammary carcinosarcoma in cat: a case report [PDF]

, 2010
A case of mammary carcinosarcoma is reported in a 13-year-old, mixed breed female cat, which was not spayed and had not received contraceptives. The patient presented extensive and coalescent nodules in all mammary glands.
A.L.S. Vieira, G.D. Cassali, J.D.G. Paniago, S.A. França, R. Serakides, C. Malm, N.M. Ocarino   +6 more
core   +1 more source

Ovarian Teratoid Carcinosarcoma Is an Aggressive Tumor of Probable Mullerian Derivation with a Carcinosarcomatous and Mixed Germ-Cell Morphology

Case Reports in Oncology, 2019
Ovarian carcinosarcoma is also referred to as malignant mixed Mullerian tumor (MMMT). It is a rare neoplasm, and although it represents less than 5% of malignant ovarian tumors, it remains generally well-known among clinicians and pathologists. Rarer yet
Courtney Fox, Nichole Allen, Veronica Schimp, John Maksem   +3 more
doaj   +1 more source