Translating cardiovascular ion channel and Ca2+ signalling mechanisms into therapeutic insights
Abstract figure legend This white paper integrates mechanistic discoveries across ion channel biology, Ca2+ signalling and multiscale cardiovascular physiology to highlight new opportunities for accelerating research and guiding next‐generation therapies. Printed with permission from ®Anita Impagliazzo Medical Illustration. [Correction added on 2 March
Silvia Marchianò +18 more
wiley +1 more source
Evaluation of bicuspid aortic valve-associated aortopathic changes using third-generation dual-source computed tomography. [PDF]
Thanihaivel E S +4 more
europepmc +1 more source
When NCX switches sides: Experimental and computational insights into Ca2+ regulation in the heart
Abstract figure legend Due to its presence inside the dyadic cleft, Na+/Ca2+ exchanger (NCX) builds a functional unit together with L‐type calcium channels and ryanodine receptors in the dyadic cleft. NCX acts bidirectionally (forward and reverse mode) dependent on extracellular calcium ([Ca2+]o) and sodium ([Na+]o) concentrations and the membrane ...
Wilhelm Neubert +6 more
wiley +1 more source
ECG-Gated 4D-CTA Assessment of Intracranial Aneurysm Wall Dynamics and Longitudinal Size Change: An Exploratory Study. [PDF]
Jankovič P +7 more
europepmc +1 more source
Presentation of preload and afterload to isolated heart preparations
Abstract figure legend The heart can be isolated, and when this is so, it must be subjected to loading conditions. Over the past few decades, various loading methods have been developed to prescribe preload and afterload to isolated working‐heart preparations.
Esau Mhandu +4 more
wiley +1 more source
Relationship Between Routine Preoperative Chest CT-Based Cardiac Parameters and Recanalization After Mechanical Thrombectomy in Patients with Acute Ischemic Stroke. [PDF]
Xia W +5 more
europepmc +1 more source
ABSTRACT Purpose Cerebrospinal fluid (CSF) flow oscillations have emerged as a potentially important marker related to brain clearance, but their acquisition often relies on specialized imaging MRI sequences. The purpose of this work was to enable quantitative assessment of CSF flow associated with cardiac, respiratory, and low‐frequency cycles using ...
Pontus Söderström +5 more
wiley +1 more source
Utility of breath-hold half-Fourier single-shot turbo spin-echo with deep learning-based reconstruction for acquiring fat-suppressed T2-weighted images of the pancreas. [PDF]
Nonaka T +10 more
europepmc +1 more source
Generative restoration for cardiac PET attenuation correction: a two-stage 3D DDIM framework optimizing fidelity and clinical controllability. [PDF]
Deng J +8 more
europepmc +1 more source

