Results 171 to 180 of about 220,689 (315)

The Danish Out-of-Hospital Cardiac Arrest Trial: A Statistical Analysis Plan. [PDF]

Acta Anaesthesiol Scand
Mølstrøm S, Møller JE, Schmidt H, Grejs AM, Christensen S, Kjærgaard J, Hassager C, Meyer MAS, Andersen LPK, Rasmussen BS, Andreasen JB, Möller S.   +11 more
europepmc   +1 more source

Oral Delivery Systems for Food‐Derived Bioactive Peptides: Enhancing Stability, Bioavailability, and Health Benefits

Advanced Science, EarlyView.
Advanced delivery systems—including nanoparticles, nanoemulsions, liposomes, and hydrogels—protect food‐derived bioactive peptides from gastrointestinal degradation and bitterness. These systems enable pH‐responsive release, enhance intestinal absorption, and improve therapeutic efficacy against oxidative stress, metabolic disorders, cancer, and ...
Yu Xu, Fan Li, Runan Zhao, Tao Shu, Weihong Min, Bei‐Wei Zhu   +5 more
wiley   +1 more source

Dexamethasone Versus Placebo in Comatose Survivors of Out-of-Hospital Cardiac Arrest: Study Protocol for a Multicenter Randomized Comparison Within the Danish Out-of-Hospital Cardiac Arrest Trial (DANOHCA). [PDF]

Acta Anaesthesiol Scand
Andreasen JB, Grejs AM, Mölström S, Andersen LPK, Möller S, Christensen S, Schmidt H, Møller JE, Meyer MAS, Kjærgaard J, Erbs AW, Rasmussen BS, Hassager C.   +12 more
europepmc   +1 more source

Trafficking Deficiency of TMEM175 Variants in Parkinson's Disease Pathogenesis and the Prospects of Precision Medicine

Advanced Science, EarlyView.
This study identifies that the PD‐associated TMEM175‐L156P variant disrupts lysosomal ion channel trafficking by causing aberrant endoplasmic reticulum retention. A “chaperone–agonist” bifunctional small molecule restores TMEM175‐L156P lysosomal localization and channel function, thereby alleviating PD‐relevant cellular phenotypes and highlighting a ...
Ting Luo, Yu He, Shuyao Li, Haoyu Guan, Ruili Cui, Yu Shi, Zhongwen Jiang, Siyu Wang, Xuan Li, Jiyuan Li, Mei Hu, Yupeng Zhou, Beisha Tang, Yanyan Zhang, Zhaobing Gao, Yu Zhou, Zhenhua Liu, Ping Li   +17 more
wiley   +1 more source

Prophylactic Olanzapine Versus Placebo in Comatose Survivors of Out-of-Hospital Cardiac Arrest: Protocol for a Multicenter Randomized Comparison Within the Danish Out-of-Hospital Cardiac Arrest (DANOHCA) Trial. [PDF]

Acta Anaesthesiol Scand
Liebetrau B, Grejs AM, Meyer MAS, Andersen LPK, Möller S, Mølstrøm S, Møller JE, Schmidt H, Christensen S, Kjærgaard J, Hassager C, Rasmussen BS, Andreasen JB.   +12 more
europepmc   +1 more source

Pasta, a Versatile Transcriptomic Clock, Maps the Chemical and Genetic Determinants of Aging and Rejuvenation

Advanced Science, EarlyView.
Pasta is a transcriptomic aging clock built on an age‐shift learning framework and trained on 17 000 samples across 21 datasets. It accurately predicts relative biological age across tissues, platforms, and species, captures stemness‐to‐senescence transitions, and identifies age‐modulatory perturbations.
Jérôme Salignon, Maria Tsiokou, Patricia Marqués, Enriqueta Rodríguez‐Diaz, Hazel Ang, Federico Pietrocola, Christian G. Riedel   +6 more
wiley   +1 more source

Renal Tubular Epithelial CRLF1 Interacts With ITGB1 to Accelerate Fibrosis During the Transition From AKI to CKD

Advanced Science, EarlyView.
During renal fibrosis, SMAD3 acts as a transcription factor for CRLF1, promoting its expression and secretion. CRLF1 then binds to ITGB1 via an autocrine mechanism, activating the PI3K‐AKT signaling pathway to mediate renal fibrosis. This accelerates the progression from AKI to CKD, highlighting the therapeutic potential of targeting CRLF1 for ...
Chunjie Wang, Yan Zhang, Fang Bai, Shankui Qian, Feng Feng, Fangyi Lu, Jiahui Fan, Kuipeng Yu, Xiangdong Yang   +8 more
wiley   +1 more source

Association Between Geomagnetic Activity and Unsuccessful Out-of-Hospital Cardiac Arrest. [PDF]

Geohealth
Vencloviene J, Krikscionaitiene A, Darginavicius L, Baksevice D, Vaitkaitiene E, Vaitkaitis D, Dobozinskas P.   +6 more
europepmc   +1 more source

From Flexible to Conformable Pressure Sensors: Mechanisms, Materials, and Biomedical Applications

Advanced Electronic Materials, EarlyView.
This review highlights recent progress, challenges and future opportunities in pressure sensing for advanced biomedical applications. We summarize key transduction mechanisms and emerging material strategies, discuss representative wearable and implantable applications for continuous physiological monitoring and provide a focused perspective on barrier
Rishabh B. Mishra, Andrea Ottomaniello, Virgilio Mattoli   +2 more
wiley   +1 more source

Temperature Control After In-Hospital Cardiac Arrest: Outcomes From the Discover In-Hospital Cardiac Arrest Cohort. [PDF]

Crit Care Med
Andrea L, Berg KM, Johnson NJ, Mitchell OJL, Pearce AK, Green A, Elmer J, Huespe IA, Lanspa MJ, Davis GR, Peltan ID, Herman NS, Malhotra R, Bangar MD, Peterson LN, Wadud N, Mayfield H, Vaena M, Valdez P, Howard TE, Loewe MR, Faiver L, Tam J, Halablab SM, Kaviyarasu A, Baram M, Chan V, Crisci T, Rosal N, Ghamande SA, White HD, Anderson B, Dugar S, Mehkri O, Saleem T, Vine J, Lee JH, Norton DL, Gaillard JP, Wachs T, Herbert JT, Krishnamoorthy V, Wardi G, Long MT, Craigova L, DeMasi SC, Shipley K, Khan A, Schnittke N, Hubel K, Crowley CP, Hansen CK, Dodd KW, Choudhury S, March C, Martinez A, Reyes A, Joffe AM, Bui A, Denchev K, Bissell Turpin BD, Fowajuh R, Ward J, Khan A, Chang C, Richieri E, Mirofsky M, Sagardia J, Piezny D, Gira AR, Cunto E, Khan R, Al-Hakim T, Gong MN, Moskowitz A, Discovery, the Critical Care Research Network of the Society of Critical Care Medicine.   +76 more
europepmc   +1 more source