Results 31 to 40 of about 1,013,426 (312)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Neuropsychological outcome after cardiac arrest: a prospective case control sub-study of the Targeted hypothermia versus targeted normothermia after out-of-hospital cardiac arrest trial (TTM2)

BMC Cardiovascular Disorders, 2020
Background This study is designed to provide detailed knowledge on cognitive impairment after out-of-hospital cardiac arrest (OHCA) and its relation to associated factors, and to validate the neurocognitive screening of the Targeted Hypothermia versus ...
Erik Blennow Nordström, Gisela Lilja, Susanna Vestberg, Susann Ullén, Hans Friberg, Niklas Nielsen, Katarina Heimburg, Lars Evald, Marco Mion, Magnus Segerström, Anders M. Grejs, Thomas Keeble, Hans Kirkegaard, Hanna Ljung, Sofia Rose, Matthew P. Wise, Christian Rylander, Johan Undén, Tobias Cronberg   +18 more
doaj   +1 more source

A Retrospective Study: Quick Scoring of Symptoms to Estimate the Risk of Cardiac Arrest in the Emergency Department

Emergency Medicine International, 2022
Purpose. At present, not enough is known about the symptoms before cardiac arrest. The purpose of this study is to describe the precursor symptoms of cardiac arrest, focusing on the relationship between symptoms and cardiac arrest, and to establish a ...
Yaoke Xu, Hua Zhang, Zongxuan Zhao, Kaifeng Wen, Ci Tian, Qiangrong Zhai, Yi Bai, Shu Li, Hongxia Ge, Xiaodan Li, Qidi Zhou, Qingbian Ma   +11 more
doaj   +1 more source

Knowledge and attitudes to cardiopulmonary resuscitation (CPR)– a cross-sectional population survey in Sweden

Resuscitation Plus, 2021
Aim of the study: Rates of bystander CPR are increasing, yet mortality after out-of-hospital cardiac arrest (OHCA) remains high. The aim of this survey was to explore public knowledge and attitudes to CPR.
Cecilia Andréll, Camilla Christensson, Liselott Rehn, Hans Friberg, Josef Dankiewicz   +4 more
doaj   +1 more source

Targeted temperature management in cardiac arrest: survival evaluated by propensity score matching [PDF]

, 2017
Background: Targeted temperature management in cardiac arrest was introduced following evidence of increased survival from two controlled trials published in 2002.
Eirik A. Buanes, Jon-Kenneth Heltne, Guttormsen, Anne-Berit, Langørgen, Jørund, Heltne, Jon-Kenneth, Karl O. Hufthammer, Jørund Langørgen, Anne-Berit Guttormsen, Buanes, Eirik Alnes, Hufthammer, Karl O.   +9 more
core   +1 more source

[18F]Fluorodeprenyl‐D2 PET as a Tool to Monitor Disease Activity in GAD65‐Ab Autoimmune Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate [18F]fluorodeprenyl‐D2 ([18F]F‐DED) positron‐emission tomography (PET) imaging as a biomarker of disease activity in autoimmune encephalitis (AIE) associated with glutamic acid decarboxylase 65 (GAD65) antibodies. Methods [18F]F‐DED PET was performed in 25 GAD65‐AIE patients and 8 controls using dynamic (0–60 min) and ...
Julia S. Dorneich, Jonathan A. Gernert, Hanna Zimmermann, Lisa Tagnin, Marianthi Zeinaki, Laura Sanzo, Letizia Vogler, Elisabeth Kaufmann, Justina Dargvainiene, Frank Leypoldt, Gérard N. Bischof, Robert Perneczky, Boris‐Stephan Rauchmann, Simon Lindner, Günter U. Höglinger, Rudolf A. Werner, Martin Kerschensteiner, Tania Kümpfel, Matthias Brendel, Franziska S. Thaler   +19 more
wiley   +1 more source

Dynamic Risk Trajectories for Sudden Cardiac Arrest: The Role of Recurrent Cardiovascular Events

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Although cardiovascular events increase sudden cardiac arrest (SCA) risk, the impact of recurrent events on subsequent SCA risk in a contemporary population is unknown.
Marita Knudsen Pope, Harpriya Chugh, Thien Tan Tri Tai Truyen, Marco Mathias, Audrey Uy‐Evanado, Honghuang Lin, Dan Atar, Nichole Bosson, Kyndaron Reinier, Emelia J. Benjamin, Sumeet S. Chugh   +10 more
doaj   +1 more source

Hemodynamic Patterns Before Inhospital Cardiac Arrest in Critically Ill Children: An Exploratory Study

Critical Care Explorations, 2021
OBJECTIVES:. To characterize prearrest hemodynamic trajectories of children suffering inhospital cardiac arrest. DESIGN:. Exploratory retrospective analysis of arterial blood pressure and electrocardiogram waveforms. SETTING:.
Ely Erez, BS, Mjaye L. Mazwi, MBChB, Alexandra M. Marquez, MD, MSTR, Michael-Alice Moga, MD, MSc, Danny Eytan, MD, PhD   +4 more
doaj   +1 more source