Results 31 to 40 of about 357,051 (309)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, Volume 20, Issue 6, Page 1398-1419, June 2026.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Neuropsychological outcome after cardiac arrest: a prospective case control sub-study of the Targeted hypothermia versus targeted normothermia after out-of-hospital cardiac arrest trial (TTM2)

BMC Cardiovascular Disorders, 2020
Background This study is designed to provide detailed knowledge on cognitive impairment after out-of-hospital cardiac arrest (OHCA) and its relation to associated factors, and to validate the neurocognitive screening of the Targeted Hypothermia versus ...
Erik Blennow Nordström, Gisela Lilja, Susanna Vestberg, Susann Ullén, Hans Friberg, Niklas Nielsen, Katarina Heimburg, Lars Evald, Marco Mion, Magnus Segerström, Anders M. Grejs, Thomas Keeble, Hans Kirkegaard, Hanna Ljung, Sofia Rose, Matthew P. Wise, Christian Rylander, Johan Undén, Tobias Cronberg   +18 more
doaj   +1 more source

A Retrospective Study: Quick Scoring of Symptoms to Estimate the Risk of Cardiac Arrest in the Emergency Department

Emergency Medicine International, 2022
Purpose. At present, not enough is known about the symptoms before cardiac arrest. The purpose of this study is to describe the precursor symptoms of cardiac arrest, focusing on the relationship between symptoms and cardiac arrest, and to establish a ...
Yaoke Xu, Hua Zhang, Zongxuan Zhao, Kaifeng Wen, Ci Tian, Qiangrong Zhai, Yi Bai, Shu Li, Hongxia Ge, Xiaodan Li, Qidi Zhou, Qingbian Ma   +11 more
doaj   +1 more source

Early Outcomes of Out-of-Hospital Cardiac Arrest after Early Defibrillation: a 24 Months Retrospective Analysis [PDF]

, 2006
Introduction: Cardiovascular disease remains the most common cause of death in the United States and most other Western nations. Among these deaths, sudden, out-of-hospital cardiac arrest claims approximately 1000 lives each day in the United States ...
Barbara Severgnini, Enrico Maria Greco, Paolo Terranova, Paolo Valli, Simonetta Dell'Orto   +4 more
core   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Knowledge and attitudes to cardiopulmonary resuscitation (CPR)– a cross-sectional population survey in Sweden

Resuscitation Plus, 2021
Aim of the study: Rates of bystander CPR are increasing, yet mortality after out-of-hospital cardiac arrest (OHCA) remains high. The aim of this survey was to explore public knowledge and attitudes to CPR.
Cecilia Andréll, Camilla Christensson, Liselott Rehn, Hans Friberg, Josef Dankiewicz   +4 more
doaj   +1 more source

Sudden cardiac arrest and coexisting mitral valve prolapse: a case report and literature review [PDF]

, 2016
The aetiology of sudden cardiac arrest can often be identified to underlying cardiac pathology. Mitral valve prolapse is a relatively common valvular pathology with symptoms manifesting with increasing severity of mitral regurgitation (MR). It is unusual
Ahmed, M, Fletcher, N, Roshdy, A, Sharma, R   +3 more
core   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Effect of Cardiac Arrest Center Protocol Implementation on Survival After Nontraumatic Out‐of‐Hospital Cardiac Arrest

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Evidence on the effect of treatment at a cardiac arrest center (CAC) on clinical outcomes is incomplete and conflicting. The aim was to evaluate the effect of treatment at a CAC on survival after out‐of‐hospital cardiac arrest.
Georg Stachel, Lisa Ruft, Niklas Hertenberger, Gerrit Eichner, Karsten Lenk, Dominik Michalski, Joseph Classen, Sirak Petros, Sebastian Stehr, Ulrich Laufs, André Gries   +10 more
doaj   +1 more source

Factors associated with post-arrest withdrawal of life-sustaining therapy. [PDF]

, 2017
INTRODUCTION: Most successfully resuscitated cardiac arrest patients do not survive to hospital discharge. Many have withdrawal of life sustaining therapy (WLST) as a result of the perception of poor neurologic prognosis.
Abella, Benjamin S., Gaieski, David F., Grossestreuer, Anne V., Haukoos, Jason S., Ikeda, Daniel J., Moskowitz, Ari, Perman, Sarah M., Wiebe, Douglas J.   +7 more
core   +1 more source