FEBS Open Bio, EarlyView.The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer +7 more
wiley +1 more source
Factors associated with post-arrest withdrawal of life-sustaining therapy. [PDF]
, 2017 INTRODUCTION: Most successfully resuscitated cardiac arrest patients do not survive to hospital discharge. Many have withdrawal of life sustaining therapy (WLST) as a result of the perception of poor neurologic prognosis.
Abella, Benjamin S. +7 more
core +1 more source
Pre-arrest and intra-arrest prognostic factors associated with survival after in-hospital cardiac arrest : systematic review and meta-analysis [PDF]
, 2019 : Objective: To determine associations between important pre-arrest and intra-arrest prognostic factors and survival after in-hospital cardiac arrest. Design: Systematic review and meta-analysis.
Cheng, Wei +12 more
core +1 more source
Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer
Aging and Cancer, EarlyView.Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss +12 more
wiley +1 more source
The association between hemoglobin concentration and neurologic outcome after cardiac arrest. [PDF]
, 2016 PURPOSE: The purpose of the study is to determine the association between hemoglobin concentration (Hgb) and neurologic outcome in postarrest patients. METHODS: We conducted a retrospective cohort study using the Penn Alliance for Therapeutic Hypothermia
Dodampahala, Kalani +6 more
core +1 more source
Sudden cardiac arrest and coexisting mitral valve prolapse: a case report and literature review [PDF]
, 2016 The aetiology of sudden cardiac arrest can often be identified to underlying cardiac pathology. Mitral valve prolapse is a relatively common valvular pathology with symptoms manifesting with increasing severity of mitral regurgitation (MR). It is unusual
Ahmed, M +3 more
core +1 more source
Lessons Learned From a Delayed‐Start Trial of Modafinil for Freezing of Gait in Parkinson's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Freezing of gait (FOG) in people with Parkinson's disease (PwPD) is debilitating and has limited treatments. Modafinil modulates beta/gamma band activity in the pedunculopontine nucleus (PPN), like PPN deep brain stimulation. We therefore tested the hypothesis that Modafinil would improve FOG in PwPD.
Tuhin Virmani +8 more
wiley +1 more source
Predictors and outcomes of perioperative cardiac arrest in children undergoing noncardiac surgery
BJA Open, 2023 Background: Perioperative cardiac arrest continues to occur. This study aims to identify risk factors for perioperative cardiac arrest in children presenting for noncardiac surgery and characterise its outcomes.
Carine Foz +4 more
doaj +1 more source
Postcardiac arrest syndrome: from immediate resuscitation to long-term outcome. [PDF]
, 2011 International audienceABSTRACT: Prognosis of post-cardiac arrest patients remains very bleak, not only because of anoxic-ischemic neurological damage, but also because of the "post-cardiac arrest syndrome", a phenomenon often enough severe to cause death
Mongardon, Nicolas +6 more
core +3 more sources
Understanding Challenges to High-quality Pediatric Out-of-Hospital Cardiac Arrest Resuscitation Performance [PDF]
, 2023 Amanda O’Halloran, Akira Nishisaki
openalex +1 more source