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Cardiac Resynchronisation with Conduction System Pacing [PDF]

Arrhythmia & Electrophysiology Review, 2023
To date, biventricular pacing (BiVP) has been the standard pacing modality for cardiac resynchronisation therapy. However, it is non-physiological, with the activation spreading between the left ventricular epicardium and right ventricular endocardium ...
Fatima M Ezzeddine, Isaac G Leon, Yong-Mei Cha   +2 more
doaj   +6 more sources

Lineages of the Cardiac Conduction System [PDF]

Journal of Cardiovascular Development and Disease, 2017
The cardiac conduction system (CCS) initiates and coordinately propagates the electrical impulse to orchestrate the heartbeat. It consists of a set of interconnected components with shared properties.
Rajiv Mohan, Bas J. Boukens, Vincent M. Christoffels   +2 more
doaj   +7 more sources

Dbh + catecholaminergic cardiomyocytes contribute to the structure and function of the cardiac conduction system in murine heart [PDF]

Nature Communications, 2023
The heterogeneity of functional cardiomyocytes arises during heart development, which is essential to the complex and highly coordinated cardiac physiological function.
Tianyi Sun, Alexander Grassam-Rowe, Zhaoli Pu, Yangpeng Li, Huiying Ren, Yanru An, Xinyu Guo, Wei Hu, Ying Liu, Yuqing Zheng, Zhu Liu, Kun Kou, Xianhong Ou, Tangting Chen, Xuehui Fan, Yangyang Liu, Shu Tu, Yu He, Yue Ren, Ao Chen, Zhouchun Shang, Zhidao Xia, Lucile Miquerol, Nicola Smart, Henggui Zhang, Xiaoqiu Tan, Weinian Shou, Ming Lei   +27 more
doaj   +3 more sources

High resolution 3-Dimensional imaging of the human cardiac conduction system from microanatomy to mathematical modeling [PDF]

Scientific Reports, 2017
Cardiac arrhythmias and conduction disturbances are accompanied by structural remodelling of the specialised cardiomyocytes known collectively as the cardiac conduction system.
Robert S. Stephenson, Andrew Atkinson, Petros Kottas, Filip Perde, Fatemeh Jafarzadeh, Mike Bateman, Paul A. Iaizzo, Jichao Zhao, Henggui Zhang, Robert H. Anderson, Jonathan C. Jarvis, Halina Dobrzynski   +11 more
doaj   +3 more sources

Transcriptional regulation of the postnatal cardiac conduction system heterogeneity [PDF]

Nature Communications, 2023
The cardiac conduction system (CCS) is a network of specialized cardiomyocytes that coordinates electrical impulse generation and propagation for synchronized heart contractions.
Yena Oh, Rimshah Abid, Saif Dababneh, Marwan Bakr, Termeh Aslani, David P. Cook, Barbara C. Vanderhyden, Jin G. Park, Nikhil V. Munshi, Chi-Chung Hui, Kyoung-Han Kim   +10 more
doaj   +3 more sources

Development and Function of the Cardiac Conduction System in Health and Disease [PDF]

Journal of Cardiovascular Development and Disease, 2017
The generation and propagation of the cardiac impulse is the central function of the cardiac conduction system (CCS). Impulse initiation occurs in nodal tissues that have high levels of automaticity, but slow conduction properties.
David S. Park, Glenn I. Fishman
doaj   +3 more sources

Transcriptional Patterning of the Ventricular Cardiac Conduction System. [PDF]

Circ Res, 2020
Supplemental Digital Content is available in the text. Rationale: The heartbeat is organized by the cardiac conduction system (CCS), a specialized network of cardiomyocytes. Patterning of the CCS into atrial node versus ventricular conduction system (VCS)
Burnicka-Turek O, Broman MT, Steimle JD, Boukens BJ, Petrenko NB, Ikegami K, Nadadur RD, Qiao Y, Arnolds DE, Yang XH, Patel VV, Nobrega MA, Efimov IR, Moskowitz IP.   +13 more
europepmc   +4 more sources

First in situ 3D visualization of the human cardiac conduction system and its transformation associated with heart contour and inclination. [PDF]

Sci Rep, 2021
Current advanced imaging modalities with applied tracing and processing techniques provide excellent visualization of almost all human internal structures in situ; however, the actual 3D internal arrangement of the human cardiac conduction system (CCS ...
Kawashima T, Sato F.
europepmc   +4 more sources

Transcriptomic Profiling of the Developing Cardiac Conduction System at Single-Cell Resolution. [PDF]

Circ Res, 2019
RATIONALE The cardiac conduction system (CCS) consists of distinct components including the sinoatrial node (SAN), atrioventricular node (AVN), His bundle, bundle branches (BB) and Purkinje fibers (PF).
Goodyer WR, Beyersdorf BM, Paik DT, Tian L, Li G, Buikema JW, Chirikian O, Choi S, Venkatraman S, Adams EL, Tessier-Lavigne M, Wu JC, Wu SM.   +12 more
europepmc   +4 more sources

Developmental Origin of the Cardiac Conduction System: Insight from Lineage Tracing. [PDF]

Pediatr Cardiol, 2018
The components of the cardiac conduction system (CCS) generate and propagate the electrical impulse that initiates cardiac contraction. These interconnected components share properties, such as automaticity, that set them apart from the working ...
Mohan RA, Boukens BJ, Christoffels VM.
europepmc   +4 more sources