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Lineages of the Cardiac Conduction System [PDF]

Journal of Cardiovascular Development and Disease, 2017
The cardiac conduction system (CCS) initiates and coordinately propagates the electrical impulse to orchestrate the heartbeat. It consists of a set of interconnected components with shared properties.
Rajiv Mohan, Bas J. Boukens, Vincent M. Christoffels   +2 more
doaj   +6 more sources

Neonatal Deletion of Hand1 and Hand2 within Murine Cardiac Conduction System Reveals a Novel Role for HAND2 in Rhythm Homeostasis [PDF]

Journal of Cardiovascular Development and Disease, 2022
The cardiac conduction system, a network of specialized cells, is required for the functioning of the heart. The basic helix loop helix factors Hand1 and Hand2 are required for cardiac morphogenesis and have been implicated in cardiac conduction system ...
Rajani M. George, Shuai Guo, Beth A. Firulli, Michael Rubart, Anthony B. Firulli   +4 more
doaj   +2 more sources

Dbh + catecholaminergic cardiomyocytes contribute to the structure and function of the cardiac conduction system in murine heart [PDF]

Nature Communications, 2023
The heterogeneity of functional cardiomyocytes arises during heart development, which is essential to the complex and highly coordinated cardiac physiological function.
Tianyi Sun, Alexander Grassam-Rowe, Zhaoli Pu, Yangpeng Li, Huiying Ren, Yanru An, Xinyu Guo, Wei Hu, Ying Liu, Yuqing Zheng, Zhu Liu, Kun Kou, Xianhong Ou, Tangting Chen, Xuehui Fan, Yangyang Liu, Shu Tu, Yu He, Yue Ren, Ao Chen, Zhouchun Shang, Zhidao Xia, Lucile Miquerol, Nicola Smart, Henggui Zhang, Xiaoqiu Tan, Weinian Shou, Ming Lei   +27 more
doaj   +2 more sources

Sudden Unexpected Infant and Perinatal Death: Pathological Findings of the Cardiac Conduction System [PDF]

Diagnostics
Objective: Sudden infant death syndrome (SIDS), sudden neonatal unexpected death (SNUD), and sudden intrauterine unexpected death (SIUD) are major unsolved, shocking forms of death that occur frequently and without warning.
Giulia Ottaviani, Patrizia Leonardi, Massimo Del Fabbro, Simone G. Ramos   +3 more
doaj   +2 more sources

Cardiac Resynchronisation with Conduction System Pacing

Arrhythmia & Electrophysiology Review, 2023
To date, biventricular pacing (BiVP) has been the standard pacing modality for cardiac resynchronisation therapy. However, it is non-physiological, with the activation spreading between the left ventricular epicardium and right ventricular endocardium ...
Fatima M Ezzeddine, Isaac G Leon, Yong-Mei Cha   +2 more
doaj   +4 more sources

Development of the Cardiac Conduction System. [PDF]

Cold Spring Harb Perspect Biol, 2020
The cardiac conduction system initiates and propagates each heartbeat. Specialized conducting cells are a well-conserved phenomenon across vertebrate evolution, although mammalian and avian species harbor specific components unique to organisms with four-chamber hearts.
Bhattacharyya S, Munshi NV.
europepmc   +3 more sources

Pleural and pericardial effusions with cardiac conduction system and myocardial involvement: A rare presentation of sarcoidosis [PDF]

Radiology Case Reports, 2022
Sarcoidosis is a granulomatous immune disorder that can infiltrate many organ systems. When the cardiac system is involved, the myocardium and conduction system are frequently affected. We report the case of a patient presenting with complete heart block
Christine Vincent, BA, Oleg Reznik, MD, Joel Raju, MD, Alina Popa, MD   +3 more
doaj   +2 more sources

Conduction System Pacing for Cardiac Resynchronisation

Arrhythmia & Electrophysiology Review, 2021
Conduction system pacing (CSP) is a technique of pacing that involves implantation of permanent pacing leads along different sites of the cardiac conduction system and includes His bundle pacing and left bundle branch pacing. There is an emerging role for CSP to achieve cardiac resynchronisation in patients with heart failure with reduced ejection ...
Parikshit S Sharma, Pugazhendhi Vijayaraman   +1 more
doaj   +3 more sources

Development and Function of the Cardiac Conduction System in Health and Disease

Journal of Cardiovascular Development and Disease, 2017
The generation and propagation of the cardiac impulse is the central function of the cardiac conduction system (CCS). Impulse initiation occurs in nodal tissues that have high levels of automaticity, but slow conduction properties.
David S. Park, Glenn I. Fishman
doaj   +3 more sources

Transcriptional regulation of the postnatal cardiac conduction system heterogeneity [PDF]

Nature Communications
The cardiac conduction system (CCS) is a network of specialized cardiomyocytes that coordinates electrical impulse generation and propagation for synchronized heart contractions.
Yena Oh, Rimshah Abid, Saif Dababneh, Marwan Bakr, Termeh Aslani, David P. Cook, Barbara C. Vanderhyden, Jin G. Park, Nikhil V. Munshi, Chi-Chung Hui, Kyoung-Han Kim   +10 more
doaj   +2 more sources