Results 61 to 70 of about 369,292 (356)
Zebrafish Models in Therapeutic Research of Cardiac Conduction Disease
Frontiers in Cell and Developmental Biology, 2021 Malfunction in the cardiac conduction system (CCS) due to congenital anomalies or diseases can cause cardiac conduction disease (CCD), which results in disturbances in cardiac rhythm, leading to syncope and even sudden cardiac death.
Rui Gao, Jie Ren
doaj +1 more source
Development of the cardiac conduction system in zebrafish.
Gene Expression Patterns, 2016 The cardiac conduction system (CCS) propagates and coordinates the electrical excitation that originates from the pacemaker cells, throughout the heart, resulting in rhythmic heartbeat. Its defects result in life-threatening arrhythmias and sudden cardiac death.
K. Poon +4 more
semanticscholar +5 more sources
FEBS Open Bio, EarlyView.Berberine–cinnamic acid co‐crystal (BBR‐CA) inhibits the phosphorylation of the phosphatidylinositol 3‐kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway, suppressing the transfer of pre‐sterol regulatory element‐binding proteins‐1 (SREBP‐1) from the endoplasmic reticulum to the nucleus. This results in a decrease in the expression level of
Wenheng Gao +7 more
wiley +1 more source
Coordinated Tbx3/Tbx5 transcriptional control of the adult ventricular conduction system
eLifeThe cardiac conduction system (CCS) orchestrates the electrical impulses that enable coordinated contraction of the cardiac chambers. The T-box transcription factors TBX3 and TBX5 are required for CCS development and associated with overlapping and ...
Ozanna Burnicka-Turek +12 more
doaj +1 more source
Excitation model of cardiac p cells of the cardiac conduction system [PDF]
, 2015 The article considers elaboration of the mathematical model of cardiac electrical activity which will allow investigating excitation propagation processes at all sites of the cardiac conduction system.
Babich, L. N. +1 more
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Sodium leak through K2P potassium channels and cardiac arrhythmia, an emerging theme. [PDF]
, 2017 In this issue of EMBO Molecular Medicine, Decher et al (2017) identify a point mutation in the K2P2 (TREK‐1) potassium (K+) channel that changes function in just those ways expected to predispose to right ventricular outflow tract (RVOT) ventricular
Goldstein, Steve An
core +2 more sources
Europace, 2023 Conduction system pacing (CSP) has emerged as a more physiological alternative to right ventricular pacing and is also being used in selected cases for cardiac resynchronization therapy. His bundle pacing was first introduced over two decades ago and its
H. Burri +12 more
semanticscholar +1 more source
The impact of Hnrnpl deficiency on transcriptional patterns of developing muscle cells
FEBS Open Bio, EarlyView.We performed nanopore whole‐transcriptome sequencing comparing RNA from Hnrnpl‐knockdown versus control C2C12 myoblasts to investigate the contributions of Hnrnpl to muscle development. Our results indicate that Hnrnpl regulates the expression of genes involved with Notch signaling and skeletal muscle, particularly splicing patterns of specific muscle ...
Hannah R. Littel +8 more
wiley +1 more source
Journal of Cardiovascular Development and Disease, 2021 The rapid propagation of electrical activity through the ventricular conduction system (VCS) controls spatiotemporal contraction of the ventricles. Cardiac conduction defects or arrhythmias in humans are often associated with mutations in key cardiac ...
Caroline Choquet +3 more
doaj +1 more source
Digital 3D reconstruction of two parahissian accessory bundles in a case of Wolff-Parkinson-White syndrome [PDF]
, 2018 Three-dimensional reconstruction of digitized histological serial sections of the cardiac conduction system yielded two accessory pathways in a case of a 24-day-old male infant who died after a short period of illness with ECG findings of Wolff-Parkinson-
Hardmeier, Thomas +3 more
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