Results 61 to 70 of about 141,036 (291)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Unwind to the beat: chromatin and cardiac conduction

The Journal of Clinical Investigation, 2023
How chromatin accessibility and structure endow highly specialized cells with their unique phenotypes is an area of intense investigation. In the mammalian heart, an exclusive subset of cardiac cells comprise the conduction system.
Douglas J. Chapski, Thomas M. Vondriska
doaj   +1 more source

Complex patterns of spontaneous initiations and terminations of reentrant circulation in a loop of cardiac tissue

, 2008
A two-component model is developed that consists of a discrete loop of cardiac cells that circulates action potentials together with a cardiac pacing mechanism.
Anastasiou-Nana, Banville, Bub, C.K. Cheng, C.M. Baumgarten, Cain, Cain, Cain, Cao, Chay, Chen, Cheng, Cherry, Chialvo, Chow, Courtemanche, Courtemanche, Courtemanche, Cytrynbaum, D.M. Chan, De Bakker, Derksen, Downar, Elaydi, Fox, Fox, Frame, Gilmour, Girouard, Glass, H. Sedaghat, Hall, Harris, Hwang, Ito, J.W. Cain, Jack, Jalife, Kalb, Keener, Kocic, Koller, Koller, Krebs, Kunysz, Lampert, Liebovitch, Lown, M.A. Wood, Manios, Mickens, Mines, Mitchell, Moe, Nagai, Nolasco, Otani, Plonsey, Qu, Quan, Sedaghat, Sedaghat, Stein, Stubna, Ten Tusscher, Vinet, Watanabe, Watanabe, Winkle, Wood, Wood, Wood   +71 more
core   +1 more source

Termination of Reentry in an Inhomogeneous Ring of Model Cardiac Cells [PDF]

, 2002
Reentrant waves propagating in a ring or annulus of excitable media model is the basic mechanism underlying a major class of irregular cardiac rhythms known as anatomical reentry.
Christini, David J., Sinha, Sitabhra
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

His Bundle pacing for congenital complete AV block: An attempt to fix a broken heart?

Annals of Noninvasive Electrocardiology, 2022
Congenital complete atrioventricular block (CCAVB) is usually due to failure of atrioventricular nodal conduction with preservation of the His‐Purkinje system.
Giuseppe Pio Piemontese, Matteo Ziacchi, Giovanni Statuto, Andrea Angeletti, Giulia Massaro, Lorenzo Bartoli, Mauro Biffi   +6 more
doaj   +1 more source

New Insights into the Development and Morphogenesis of the Cardiac Purkinje Fiber Network: Linking Architecture and Function

Journal of Cardiovascular Development and Disease, 2021
The rapid propagation of electrical activity through the ventricular conduction system (VCS) controls spatiotemporal contraction of the ventricles. Cardiac conduction defects or arrhythmias in humans are often associated with mutations in key cardiac ...
Caroline Choquet, Lucie Boulgakoff, Robert G. Kelly, Lucile Miquerol   +3 more
doaj   +1 more source

A comparative study fourth order runge kutta-tvd Scheme and fluent software case of inlet flow problems [PDF]

, 2011
Inlet as part of aircraft engine plays important role in controlling the rate of airflow entering to the engine. The shape of inlet has to be designed in such away to make the rate of airflow does not change too much with angle of attack and also not ...
Altaher Mohamed, Mohamed Abdalwahab
core  

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Muscleblind-like 3 deficit results in a spectrum of age-associated pathologies observed in myotonic dystrophy. [PDF]

, 2016
Myotonic dystrophy type I (DM1) exhibits distinctive disease specific phenotypes and the accelerated onset of a spectrum of age-associated pathologies.
Abdallah, Walid F, Choi, Jongkyu, Comai, Lucio, Dansithong, Warunee, Dixon, Donald M, Jordan, Maria C, Lee, Han Shin, Reddy, Sita, Roos, Kenneth P, Trac, Brandon   +9 more
core   +1 more source