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Molecular and Cellular Biochemistry, 2013 The LMNA gene, which encodes the nuclear envelope protein lamin A/C, is considered to be the most common autosomal disease gene associated with familial dilated cardiomyopathy. To date, each mutation of the LMNA gene has been associated with a specific disease phenotype.
Wenting Chen +4 more
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Cardiac MRI Findings in Patients presenting With Advanced Conduction System Disease
Heart, Lung and Circulation, 2022 H. Jumaah +7 more
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Hypertrophic Cardiomyopathy and Symptomatic Conduction System Disease in Cardiac Amyloidosis
Southern Medical Journal, 2006Cardiac involvement is the most important prognostic factor in primary amyloidosis (AL). The clinical presentation of amyloid cardiomyopathy is varied and may manifest as heart failure, brady or tachyarrhythmias, syncope, angina and rarely with features of hypertrophic cardiomyopathy and advanced symptomatic conduction system disease. The management of
Praveen, Garg +5 more
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Conduction system disease in cardiac amyloidosis
Trends in Cardiovascular MedicineCardiac amyloidosis (CA) has diverse and deleterious effects on the conductive system. Atrial fibrillation is by far the most common electrophysiological manifestation of CA and is associated with more mortality, morbidity, and hospitalizations. While AF increases the risk of thrombosis regardless of the CHA2DS2-VASc score, the risk of thromboembolism ...
Ala’ Assaf +7 more
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Progress in Cardiovascular Diseases, 2005
Throughout the cardiac conduction system of each heart there were numerous destructive lesions including focal inflammatory infiltration with lymphocytes and in neighboring regions extensive focal fibrotic degeneration. These lesions involved myocytes, nerves and blood vessels.
Thomas N, James +2 more
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Throughout the cardiac conduction system of each heart there were numerous destructive lesions including focal inflammatory infiltration with lymphocytes and in neighboring regions extensive focal fibrotic degeneration. These lesions involved myocytes, nerves and blood vessels.
Thomas N, James +2 more
openaire +2 more sources
[Steinert's disease with cardiac arrhythmia. Morphological findings in the heart conduction system].
Archivos del Instituto de Cardiologia de Mexico, 1975This is a case report of a 63-year-old man with myotonic dystrophy in whom an ECG showed atrial flutter, complete A-V block, idioventricular rhythm with image of left bundle branch block and giant, wide and negative "T-U" waves. The microscopic study of the conduction system showed slight fibrosis of the SAN, fatty infiltration and cellular atrophy of ...
R, Drut, O, Velasco Vela, L, Maljar
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Novartis Foundation symposium, 2004
To unravel the complex disease phenotype of heart failure, we are utilizing an integrative approach employing genomics, physiology, and mouse genetics to identify nodal pathways for specific physiological end points such as myocyte stretch activation responses, contractility and electrical conduction.
Tara R, St Amand +2 more
openaire +1 more source
To unravel the complex disease phenotype of heart failure, we are utilizing an integrative approach employing genomics, physiology, and mouse genetics to identify nodal pathways for specific physiological end points such as myocyte stretch activation responses, contractility and electrical conduction.
Tara R, St Amand +2 more
openaire +1 more source