Results 201 to 210 of about 116,699 (313)

Redox‐Responsive Tellurium‐Bridged Covalent Organic Frameworks/PEG Composites for Targeted Therapy of Diabetic Cardiomyopathy

Advanced Science, EarlyView.
This study unlocks the immense potential of COF@polymer nanocomposites as a multifunctional therapeutic platform for targeted drug delivery in diabetic cardiomyopathy. Abstract Diabetic cardiomyopathy, a major complication of diabetes, is strongly associated with elevated levels of glycated hemoglobin (HbA1c) and reactive oxygen species (ROS). However,
Jing Xue, Jialu Zhuang, Taotao Fan, Songtao Tang, Junjun Wang, Xiaohui Liu, Jian Liu, Jin Shi, Jiaji Li, Wanjun Li, Danyou Hu, Xiaoqian Zhang, Hua Wang, Guiyang Zhang   +13 more
wiley   +1 more source

Editorial: Advancing our understanding of the cardiac conduction system to prevent arrhythmias. [PDF]

Front Physiol
Vigmond EJ, Bayer J.
europepmc   +1 more source

Discovery of a Novel and Potent Kir4.1 Inhibitor as a Safe and Rapid‐Onset Antidepressant Agent in Mice

Advanced Science, EarlyView.
The preferred derivative JX3212 demonstrates strong inhibitory activity against Kir4.1 with favorable druggability and shows significant antidepressant efficacy in vivo. Abstract Major depressive disorder is a serious psychiatric disorder for which novel and fast‐acting antidepressants are required.
Sisi Wang, Xiaoyu Zhou, Mengdan Li, Chao Zhang, Haiyan Xu, Jingyi He, Li Zhan, Yueling Gu, Hao Gu, Tianyu Tu, Hanfang Liu, Taotao Lu, Yueming Zheng, Jian Li, Zhaobing Gao, Yixiang Xu   +15 more
wiley   +1 more source

Genetic anticipation and cardiac conduction abnormalities in myotonic dystrophy type 1: implications for early stratification from a multicenter registry. [PDF]

Int J Cardiol Heart Vasc
Lorca R, Alen A, Moliner-Abós C, de Frutos F, Báez-Ferrer N, Peña-Peña ML, Villacorta E, Ripoll-Vera T, Zorio E, Martínez-Gimeno A, Bermúdez-Jiménez J, Limeres J, Tiron C, Larrañaga-Moreira JM, Cabrera-Romero E, García-Pavía P, Espinosa MA, Piqueras J, García-Hernández S, Palomino-Doza J, Soriano-Amores M, Moris G, Carrillo-Mora LM, Syris P, Alvarez-Velasco R, Gimeno JR, Muñoz C.   +26 more
europepmc   +1 more source

Effectiveness of Cardiac Resynchronization Therapy in Adult Congenital Heart Disease: A Meta-Analysis of Biventricular and Conduction System Pacing Outcomes.

Bert A.C. Zwaenepoel, Ralph M.L. Neijenhuis, Gruschen Veldtman, Nicolaas A. Blom, J.Wouter Jukema, Monique R.M. Jongbloed, Jan W. Schoones, Saskia L.M.A. Beeres, Anastasia D. Egorova   +8 more
openalex   +1 more source

Wearable and Implantable Devices for Continuous Monitoring of Muscle Physiological Activity: A Review

Advanced Science, EarlyView.
Recent advances in materials and device engineering enable continuous, real‐time monitoring of muscle activity via wearable and implantable systems. This review critically summarizes emerging technologies for tracking electrophysiological, biomechanical, and oxygenation signals, outlines fundamental principles, and highlights key challenges and ...
Zhengwei Liao, Ata Golparvar, Mohammad Javad Bathaei, Filipe Arroyo Cardoso, Clementine M. Boutry   +4 more
wiley   +1 more source

Takotsubo Syndrome and Arrhythmias: The Chicken and Egg Dilemma. [PDF]

Cureus
Bennis G, Lebbar S, Hafid S, Merzouk F.
europepmc   +1 more source

Lactylation‐Driven YTHDC1 Alleviates MASLD by Suppressing PTPN22‐Mediated Dephosphorylation of NLRP3

Advanced Science, EarlyView.
In MASLD, YTHDC1 undergoes increased lactylation and ubiquitination, reducing its expression. AARS1 mediates lactylation at lysine 565, while disrupted binding to LDHA further promotes lactylation, suppressing YTHDC1. This downregulation enhances PTPN22 mRNA stability, leading to NLRP3 dephosphorylation and activation, which exacerbates inflammation ...
Feng Zhang, Linghua Zeng, Kunkun Zou, Keying Lin, Fangting Yao, Jinglun Song, Shumeng Zhang, Hanshu Feng, Zhichao Yang, Chunlei Wang, Hongtao Diao, Xue Kong, Tengfei Pan, Joonki Kim, Tianqi Duo, Linqiang Li, Yu Bian   +16 more
wiley   +1 more source

Conduction System Pacing Improved Cardiac Functions, Myocardial Work and Functional Capacity in Heart Failure with Reduced Ejection Fraction and Right Bundle Branch Block. [PDF]

J Clin Med
Tóth AZ, Nagy L, Jenei C, Ráduly AP, Sándorfi G, Szabó KM, Kiss A, Nagy LT, Szilágyi GI, Csanádi Z.   +9 more
europepmc   +1 more source

A Review on Biodegradable Materials of Sustainable Soft Robotics and Electronics

Advanced Science, EarlyView.
Biodegradable materials are gaining increasing attention in soft robotics and electronics due to their environmental friendliness, showing great potential for sustainability. In this review, the classification of biodegradable materials, their applications in the field of soft robotics and electronics, as well as the challenges and future prospects ...
Yizhu Xie, Jiaxin Han, Xingyi Dai, Xuyang Zhang, Kangwen Xiao, Junhui Huang, Yajun Cao, Aihua Zhong, Long‐Biao Huang   +8 more
wiley   +1 more source