This study reveals the tumor‐suppressive role of TRIM38 in colorectal cancer (CRC). TRIM38 is downregulated through DNA hypermethylation and correlates with unfavorable clinical features and poor prognosis. Mechanistically, TRIM38 inhibits CRC progression by promoting K48‐linked ubiquitination of CCT6A, leading to the destabilization of c‐Myc.
Yue Zhang+10 more
wiley +1 more source
Hypocapnia, eucapnia, and hypercapnia during "Where's Waldo" search paradigms: Neurovascular coupling across the cardiac cycle and biological sexes. [PDF]
Johnson NE+5 more
europepmc +1 more source
Optical Coherence Tomography-Derived Changes in Plaque Structural Stress Over the Cardiac Cycle: A New Method for Plaque Biomechanical Assessment. [PDF]
Huang J+13 more
europepmc +1 more source
The 3-dimensional cardiac hype cycle [PDF]
openaire +3 more sources
Na+‐K+ pump cycle during β‐adrenergic stimulation of adult rat cardiac myocytes
Maxim Dobretsov+2 more
openalex +2 more sources
This study investigates the role of protein arginine methyltransferase 1 (PRMT1) in endothelial cells (ECs) in chronic obstructive pulmonary disease (COPD). Mice with endothelial‐specific PRMT1 deletion develop pulmonary hemorrhage, inflammation, and apoptosis, driven by excessive nuclear factor kappa B activation.
Thi Thuy Vy Tran+7 more
wiley +1 more source
Challenging dynamic cerebral autoregulation across the physiological CO2 spectrum: Influence of biological sex and cardiac cycle. [PDF]
Johnson NE+5 more
europepmc +1 more source
Cardiac cycle time-corrected electromechanical activation time greater than 15% is an independent risk factor for major adverse cardiovascular events in chronic heart failure outpatients. [PDF]
Zhang J, Liu W.
europepmc +1 more source
Determination of left ventricular long‐axis orientation using MRI: changes during the respiratory and cardiac cycles in normal and diseased subjects [PDF]
John E. Foster+8 more
openalex +1 more source
Comprehensive epigenomic and transcriptomic profiling revealed a dynamic enhancer landscape and gene expression program associated with nephrolithiasis, highlighting RXRα as a central transcription factor in this regulatory network. Tubular‐specific deletion of RXRα increased intrarenal CaOx crystal deposition, while its activation with Bexarotene ...
Yu Yang+12 more
wiley +1 more source