Results 201 to 210 of about 2,991,997 (281)

Determination of the Same Cardiac Cycle When Analyzing Cine Clips for Use by FetalHQ to Assess Intraobserver and Interobserver Variability. Comment on Mlodawski et al. Reproducibility Challenges in Fetal Cardiac Function Analysis with 2D Speckle-Tracking Echocardiography: Insights from FetalHQ. <i>J. Clin. Med.</i> 2025, <i>14</i>, 3301. [PDF]

J Clin Med
DeVore GR.
europepmc   +1 more source

ROS‐Responsive Nanoparticle Delivery of Dexmedetomidine Protects the Gut Vascular Barrier After Intestinal Ischemia/Reperfusion via the HDAC‐H3K27ac‐TCF4 Axis

Advanced Science, EarlyView.
A low dose of dexmedetomidine, delivered by ROS‐responsive nanoparticles, preferentially accumulates in the ischemic intestine and restores gut vascular barrier integrity after ischemia/reperfusion injury. This nanoparticle‐based strategy prevents bacterial translocation and liver damage without cardiorespiratory side effects, working through HDAC ...
Hu‐Fei Zhang, Jian‐Tong Shen, Hua‐Hua Zhang, Si‐Qi Gao, Ji‐Ao Wang, Yue‐Ling Wang, Mei‐Ling Li, Zi‐Meng Liu, Yi‐Nan Zhang, Yan Li, Xu‐Yu Zhang   +10 more
wiley   +1 more source

Timing along the cardiac cycle modulates neural signals of reward-based learning. [PDF]

Nat Commun
Fouragnan EF, Hosking B, Cheung Y, Prakash B, Rushworth M, Sel A.   +5 more
europepmc   +1 more source

SIRT5‐Mediated Desuccinylation of ACAA2 Protects Against Calcium Oxalate‐Induced Kidney Injury by Regulating Fatty Acid Oxidation to Suppress Mitochondrial Oxidative Injury and Ferroptosis

Advanced Science, EarlyView.
The SIRT5/ACAA2 axis maintains lipid metabolic homeostasis in RTECs by promoting ACAA2 desuccinylation and preserving its stability and enzymatic activity, thereby sustaining FAO and limiting PUFA and PUFA‐containing phospholipid accumulation. Under CaOx stress, SIRT5 downregulation impairs FAO, promotes oxidative stress and ferroptosis, and enhances ...
Qinhong Jiang, Caitao Dong, Yuchen Liu, Yuanquan Lou, Wenlong Lin, Sheng Li, Ziqi He   +6 more
wiley   +1 more source

Influence of cardiac cycle on myocardial extracellular volume fraction measurements with dual-layer computed tomography. [PDF]

Quant Imaging Med Surg
Nishigake D, Yamasaki Y, Hida T, Shirasaka T, Funatsu R, Kato T, Ishigami K.   +6 more
europepmc   +1 more source

Towards a Compositional Framework for Describing Human Phenotypes

Advanced Science, EarlyView.
The Phenotype Assembly Method (PhenoAM) decomposes phenotype variables into measurable Features and typed Qualifiers, enabling standardized, machine‐readable Phenome Data Elements (PhenoDEs) that preserve measurement context. Applied in the International Human Phenome Project (IHPP), the framework yields 58 371 PhenoDEs and supports component‐level ...
Wanting Hu, Yunchao Ling, Xinyue Hu, Wei Chen, Rong Zhou, Xinhao Zhuang, Yanfeng Jiang, Jialu Zhao, Xingdong Chen, Jingchun Luo, Li Jin, Guoqing Zhang   +11 more
wiley   +1 more source

Reply to DeVore, G.R. Determination of the Same Cardiac Cycle When Analyzing Cine Clips for Use by FetalHQ to Assess Intraobserver and Interobserver Variability. Comment on "Mlodawski et al. Reproducibility Challenges in Fetal Cardiac Function Analysis with 2D Speckle-Tracking Echocardiography: Insights from FetalHQ. <i>J. Clin. Med.</i> 2025, <i>14</i>, 3301". [PDF]

J Clin Med
Mlodawski J, Zmelonek-Znamirowska A, Pawlik L, Mlodawska M, Swiercz G.   +4 more
europepmc   +1 more source

An Extracellular Pore‑Targeting Peptide Defines a Designable Allosteric Site in TRPV2

Advanced Science, EarlyView.
Structure‐guided peptide engineering yields Depiv2, a highly potent and subtype‐selective TRPV2 inhibitor that binds to the extracellular pore and remodels it into a closed, non‐conductive state. Depiv2 suppresses pathological cardiac hypertrophy, establishing the TRPV2 outer pore as a designable interface for selective peptide modulation.
Aiqin Zhu, Hongkun Wang, Jiawei Wang, Xiaolu Liu, Aerziguli Aierken, Lizhen Xu, Ping Liang, Fan Yang   +7 more
wiley   +1 more source

High‐Temperature Magnetic Field Mapping Using a Single‐Crystal Diamond MEMS Resonator Array

Advanced Science, EarlyView.
A single‐crystal diamond MEMS resonator array enables magnetic‐field reconstruction with millisecond response, nanotesla level magnetic noise, and stable operation up to 573 K. Two‐ and three‐dimensional magnetic field mapping are demonstrated using ΔEeffect sensing, highlighting the potential of diamond MEMS technology for hightemperature magnetic ...
Zilong Zhang, Keyun Gu, Satoshi Koizumi, Masaya Toda, Meiyong Liao   +4 more
wiley   +1 more source

Quantification of morpho-hemodynamic changes in unruptured intracranial aneurysms with irregular pulsation during the cardiac cycle using 4D-CTA. [PDF]

Front Neurol
Chen S, Zhang W, Cheng Y, Wang G, Lv N.
europepmc   +1 more source