Results 1 to 10 of about 532,194 (165)

Diabetes-Related Cardiac Dysfunction [PDF]

Endocrinology and Metabolism, 2017
The proposal that diabetes plays a role in the development of heart failure is supported by the increased risk associated with this disease, even after correcting for all other known risk factors.
Lamario J. Williams, Brenna G. Nye, Adam R. Wende   +2 more
doaj   +3 more sources

Endothelial MerTK impairment promotes cardiac dysfunction in the condition of high fat diet [PDF]

Redox Biology
Rationale: Cardiac fibrosis formation leads to cardiac dysfunction that is mainly caused by a high fat diet accompanied by an increased accumulation of apoptotic cells.
Hongye Huang, Shijie Liu, Jingke Yao, Xiaoyuan Bai, Zhicheng Jin, Bingzhong Xue, Hang Shi, Zufeng Ding   +7 more
doaj   +2 more sources

Mitochondrial Dysfunction in Cardiac Arrhythmias

Cells, 2023
Electrophysiological and structural disruptions in cardiac arrhythmias are closely related to mitochondrial dysfunction. Mitochondria are an organelle generating ATP, thereby satisfying the energy demand of the incessant electrical activity in the heart.
Jielin Deng, Yunqiu Jiang, Zhen Bouman Chen, June-Wha Rhee, Yingfeng Deng, Zhao V. Wang   +5 more
doaj   +3 more sources

Relationships of Telomere Homeostasis with Oxidative Stress and Cardiac Dysfunction in Human Ischaemic Hearts

Antioxidants, 2021
Although the roles of telomeres and oxidative stress in ischaemic cardiomyopathy (ICM) are known, mechanisms of telomere homeostasis and their relationship with oxidative stress are incompletely understood. We performed two RNA-seq analyses (mRNA n = 23;
Estefanía Tarazón, Lorena Pérez-Carrillo, Isaac Giménez-Escamilla, Pablo Ramos-Castellanos, Luis Martínez-Dolz, Manuel Portolés, Esther Roselló-Lletí   +6 more
doaj   +1 more source

Implication of Sphingolipid Metabolism Gene Dysregulation and Cardiac Sphingosine-1-Phosphate Accumulation in Heart Failure

Biomedicines, 2022
Disturbances in sphingolipid metabolism lead to biological function dysregulation in many diseases, but it has not been described in heart failure (HF). Sphingosine-1-phosphate (S1P) levels have not ever been measured in the myocardium.
Lorena Pérez-Carrillo, Isaac Giménez-Escamilla, Luis Martínez-Dolz, Ignacio José Sánchez-Lázaro, Manuel Portolés, Esther Roselló-Lletí, Estefanía Tarazón   +6 more
doaj   +1 more source

Symptom Presentation and Access to Medical Care in Patients With Postural Orthostatic Tachycardia Syndrome: Role of Sex

CJC Open, 2021
Background: Postural orthostatic tachycardia syndrome (POTS) is a chronic form of orthostatic intolerance that primarily impacts female patients of childbearing age. The role of sex differences in POTS is not well understood.
Kate M. Bourne, BSc, Juliette Hall, Lauren E. Stiles, JD, Robert S. Sheldon, MD, PhD, Cyndya A. Shibao, MD, MSCI, Luis E. Okamoto, MD, Emily M. Garland, PhD, Alfredo C. Gamboa, MD, Amanda Peltier, MD, Andre Diedrich, MD, PhD, Italo Biaggioni, MD, David Robertson, MD, Satish R. Raj, MD, MSCI   +12 more
doaj   +1 more source

Cardiac Dysfunction Is Not Associated with Increased Reintubation Rate in Patients Treated with Post-extubation High-Flow Nasal Cannula [PDF]

Tuberculosis and Respiratory Diseases, 2022
Background Cardiac dysfunction patients have long been considered at high risk of reintubation. However, it is based on past studies in which only conventional oxygen therapy was applied after extubation.
Jae Kyeom Sim, Juwhan Choi, Jee Youn Oh, Kyung Hoon Min, Gyu Young Hur, Sung Yong Lee, Jae Jeong Shim, Young Seok Lee   +7 more
doaj   +1 more source

Prognostic Impact of Cardiac Diastolic Function and Coronary Microvascular Function on Cardiovascular Death

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023
Background Coronary microvascular dysfunction (CMD) has been considered as a possible cause of cardiac diastolic dysfunction. The current study evaluated the association between cardiac diastolic dysfunction and CMD, and their prognostic implications in ...
David Hong, Seung Hun Lee, Doosup Shin, Ki Hong Choi, Hyun Kuk Kim, Sang Jin Ha, Hyun Sung Joh, Taek Kyu Park, Jeong Hoon Yang, Young Bin Song, Joo‐Yong Hahn, Seung‐Hyuk Choi, Hyeon‐Cheol Gwon, Joo Myung Lee   +13 more
doaj   +1 more source

Sepsis-induced cardiac dysfunction: a review of pathophysiology [PDF]

Acute and Critical Care, 2020
It is well known that cardiac dysfunction in sepsis is associated with significantly increased mortality. The pathophysiology of sepsis-induced cardiac dysfunction can be summarized as involving impaired myocardial circulation, direct myocardial ...
Reverien Habimana, Insu Choi, Hwa Jin Cho, Dowan Kim, Kyoseon Lee, Inseok Jeong   +5 more
doaj   +1 more source

Proteotoxicity and Cardiac Dysfunction [PDF]

Circulation Research, 2015
Baseline physiological function of the mammalian heart is under the constant threat of environmental or intrinsic pathological insults. Cardiomyocyte proteins are thus subject to unremitting pressure to function optimally, and this depends on them assuming and maintaining proper conformation.
Patrick M, McLendon, Jeffrey, Robbins
openaire   +2 more sources