Results 221 to 230 of about 2,991,997 (281)

Developmental Environmental Chronotoxicity by Polystyrene Nanoplastics Exacerbates High‐Fat Diet‐Induced Pediatric MAFLD Through Circadian Disruption and Mitochondrial Dysfunction

Advanced Science, EarlyView.
Polystyrene nanoplastics exacerbate high‐fat diet‐induced metabolic dysfunction in an age‐dependent manner. Juvenile mice exhibit greater susceptibility, characterized by circadian disruption, impaired mitochondrial function, reduced energy metabolism, and enhanced hepatic lipid accumulation.
Peihao Xu, Shuting Huang, Leilei Zhu, Junyi Huang, Kewei Li, Guangming Li, Jiannong Wu, Mingyuan Zhou, Fangmei Zhou, Zhishan Ding, Yingzhi Shen   +10 more
wiley   +1 more source

Thickness‐Gradient Liquid Metal Connectors for Seamless Electrophysiological Sensors

Advanced Science, EarlyView.
Thickness‐gradient liquid metal interfaces with elastomeric substrates enable seamless integration between ultrathin skin‐conformal electrodes and external interconnects. The mechanically compliant connector reduces interfacial mismatch and supports stable ECG/EMG monitoring under bending and motion.
Jinyoung Kim, Jaejun Lee, Christopher E. Tabor, Vladimir V. Tsukruk   +3 more
wiley   +1 more source

A Hepatocyte‐to‐Stellate Cell Axis Couples Alternate‐Day Fasting to Liver Fibrosis Resolution via ATG7 S‐Nitrosylation

Advanced Science, EarlyView.
Alternate‐day fasting suppresses mitochondrial complex II assembly via SDHAF4 to upregulate hepatocyte eNOS. The resulting nitric oxide S‐nitrosylates ATG7 at C184 in hepatic stellate cells, restraining autophagic flux and preventing their profibrotic activation.
Xueqiang Wang, Mengqi Zeng, Cunxiao Sun, Yuhan Gou, Zhaode Feng, Weiqiang Lv, Chaoying Yan, Hansen Wu, Pengfei Zhang, Jie Xu, Ke Cao, Hao Li, Mingge Ding, Zhongbo Liu, Xing Zhang, Jiankang Liu, Xuan Zou, Zhihui Feng   +17 more
wiley   +1 more source

Nuclear Translocation of PFKFB3 Promotes Disuse‐Induced Muscle Atrophy via Scaffolding Nedd4‐Mediated JunB Ubiquitination

Advanced Science, EarlyView.
Disuse‐induced muscle atrophy is driven by a non‐metabolic, nuclear function of the enzyme PFKFB3. Acting as a scaffold, PFKFB3 facilitates Nedd4‐mediated ubiquitination and degradation of the anti‐atrophy transcription factor JunB. Inhibiting this novel PFKFB3–Nedd4–JunB signaling axis stabilizes JunB and alleviates muscle wasting, revealing a highly ...
Mengjun Ma, Yinliang Liu, Wangchang Wu, Biao Yang, Jiahao Zhuang, Haoye Yu, Rujia Mi, Yixuan Lu, Wen Yang, Hanting Yi, Chenglong Yuan, Yinfeng Gu, Hongyu Li   +12 more
wiley   +1 more source

The Importance of Electrovectorcardiographic Assessment of Intraventricular Blocks and their Relationship with the Cardiac Cycle. [PDF]

Arq Bras Cardiol
Pastore CA.
europepmc   +1 more source

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The phases of the cardiac cycle

American Heart Journal, 1972
Abstract The events of the cardiac cycle are re-evaluated on the basis of newer ideas of inertial states, compliance, and similar hemodynamic principles by the use of more precise, modern recording equipment. While these events generally agree with classic schemes, certain discrepancies which tend to cause inaccurate measurement are presented.
A A, Luisada, D M, MacCanon
openaire   +2 more sources

The cardiac cycle

Anaesthesia & Intensive Care Medicine, 2012
Abstract The heart consists of four chambers that are connected in such a way that contraction of them causes the heart to act as a pump, the right half of the heart passing blood from the venae cavae to the pulmonary circulation for oxygenation and the left half of the heart pumping oxygenated blood from the pulmonary veins into the aorta and ...
openaire   +1 more source

Oscillations of cAMP with the cardiac cycle

Biochemical and Biophysical Research Communications, 1983
Oscillations of cAMP with the cardiac cycle were demonstrated in the rat heart using a stimulator-triggered rapid freeze-clamp to decrease the temperature of the heart from 37 degrees C to -80 degrees C in 5 msec (20,000 degrees/sec) at a predetermined phase of the cardiac cycle. The nucleotide, cAMP, oscillated 60% with the cardiac cycle during normal
J, Wikman-Coffelt, R, Sievers, R J, Coffelt, W W, Parmley   +3 more
openaire   +2 more sources

The Cardiac Cycle

Abstract The cardiac cycle is a series of physiological events in which blood moves through the chambers of the heart in alternating phases of systole and diastole. Movement of blood throughout the cardiac chambers is dependent on pressure changes and gradients, generated by alternating contraction and relaxation of myocardium.
Robert Pellicer, Alaa Abd-Elsayed
openaire   +1 more source