Results 51 to 60 of about 42,032 (254)

Additive‐Manufactured, Multifunctional Bioreactor Technology for Dynamic Culture of 3D Bioprinted Tissue Models

open access: yesAdvanced Materials Technologies, EarlyView.
We introduce an additively manufactured bioreactor with a perfusion flow system and integrated temperature and pH sensors for skeletal muscle tissue biofabrication. The bioreactor's performance was evaluated by assessing the viability, spreading of the myoblast cells in a printed scaffold, and contraction of the isolated murine musculi interossei ...
Lys Sprenger   +9 more
wiley   +1 more source

Compartment-based reconstruction of acquisition-weighted 31P cardiac MRSI reduces sensitivity to cardiac motion and scan planning

open access: yesFrontiers in Physiology
Motivation:31P magnetic resonance spectroscopic imaging (31P MRSI) is a powerful technique for investigating the metabolic effects of treatments for heart failure in vivo, allowing a better understanding of their mechanism of action in patient cohorts ...
Andrew Tyler   +11 more
doaj   +1 more source

Substantive incidental cardiac findings revealed by non-cardiac CT examination of the thorax

open access: yesSouth African Journal of Radiology, 2013
Limitations inherent in CT imaging of the thorax left the heart as an ill-defined and largely ignored area. The advent of multi-detector CT scanning and shortened imaging times has allowed clear identification of cardiac structures and pathology.
Miranda Durand, N. Paul, A. Crean
doaj   +1 more source

Modulation of hERG K+ Channel Deactivation by Voltage Sensor Relaxation

open access: yesFrontiers in Pharmacology, 2020
The hERG (human-ether-à-go-go-related gene) channel underlies the rapid delayed rectifier current, Ikr, in the heart, which is essential for normal cardiac electrical activity and rhythm.
Yu Patrick Shi   +2 more
doaj   +1 more source

Deep‐Tissue Light Generation via Whispering Gallery Mode Lasing From a Commercial Nylon Fiber for Biomedical Applications

open access: yesAdvanced Materials Technologies, EarlyView.
A dyed nylon fiber is implemented inside the scattering phantom and skin tissue. The deep‐tissue light generation via whispering gallery mode lasing is demonstrated, achieving a depth of >50 times transport mean free path in scattering phantom and 3 mm beneath skin.
Dongqin Ni   +4 more
wiley   +1 more source

A model for cooperative gating of L-type Ca2+ channels and its effects on cardiac alternans dynamics.

open access: yesPLoS Computational Biology, 2018
In ventricular myocytes, membrane depolarization during the action potential (AP) causes synchronous activation of multiple L-type CaV1.2 channels (LTCCs), which trigger the release of calcium (Ca2+) from the sarcoplasmic reticulum (SR).
Daisuke Sato   +3 more
doaj   +1 more source

Cross‐Scale Hierarchical Targeted Delivery System Based on Small‐Scale Magnetic Robots

open access: yesAdvanced Robotics Research, EarlyView.
This article reviews a cross‐scale hierarchical targeted delivery system that integrates magnetic continuum robots and magnetic microrobots. By combining rapid long‐range navigation with precise microscale targeting, the system overcomes key limitations of single‐scale approaches.
Junjian Zhou   +4 more
wiley   +1 more source

Research on Data-driven PET-CT Gating Imaging Method

open access: yesYuanzineng kexue jishu
PET-CT is a multimodal imaging technology that organically combines positron emission tomography (PET) and computed tomography (CT), providing accurate and comprehensive functional imaging and structural information imaging simultaneously.
XU Shidong1, 2, 3, 4, SUN Xiaoli1, 3, 4, , LIU Shuangquan1, 3, 4, ZHENG Yushuang1, 3, 4, LI Mohan1, 3, 4, WEI Cunfeng1, 2, 3, 4
doaj   +1 more source

CaMKII-dependent regulation of cardiac Na<sup>+</sup> homeostasis

open access: yesFrontiers in Pharmacology, 2014
Na+ homeostasis is a key regulator of cardiac excitation and contraction. The cardiac voltage-gated Na+ channel, NaV1.5, critically controls cell excitability, and altered channel gating has been implicated in both inherited and acquired arrhythmias. Ca2+
Eleonora eGrandi, Anthony W Herren
doaj   +1 more source

Noncanonical electromechanical coupling paths in cardiac hERG potassium channel

open access: yesNature Communications, 2023
Potassium channels allow vital organ such as brain, heart, and muscles to function. Here, authors reveal the existence of a noncanonical kinematic chain of residues involving the S4/S1 and S1/S5 subunit interfaces that controls the gating of the hERG ...
Carlos A. Z. Bassetto   +4 more
doaj   +1 more source

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