Results 41 to 50 of about 1,015,327 (288)

Clinical Variability and Genotype Driven Outcomes in an International Cohort of 14 Pediatric FIG4 Patients

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Biallelic FIG4 variants classically cause distinct conditions characterized by peripheral neuropathy (Charcot‐Marie‐Tooth disease type 4J) or skeletal dysplasia (Yunis‐Varón syndrome). However, central nervous system involvement is increasingly recognized. The prevalence and specific characteristics of movement disorders within FIG4‐
Andrea Gangfuß, Vykuntaraju K. Gowda, Daniel Natera‐de Benito, Pinki Munot, Maria Vanegas, Alejandra Darling, Constanze Reutlinger, Laura Carrera‐Garcia, Gilbert Wunderlich, Heike Kölbel, Burkhard Stüve, David Muhmann, Lucía Monfort Belenguer, Diana‐Gabriela Barca, Viveka Santhosh Reddy C, Varunvenkat M. Srinivasan, Cristina Molina Anguita, Heinz Jungbluth, Hormos Salimi Dafsari, Thomas Rossor, Johann Böhm, Ulrike Schara‐Schmidt, Andreas Roos   +22 more
wiley   +1 more source

VALUE OF VOLUME FRACTION OF COLLAGEN IN DEVELOPMENT OF MYOCARDIUM REMODELING ATTHE PATIENTS WITH INFLAMMATORY CARDIOMYOPATHY

Евразийский Кардиологический Журнал, 2014
Objective. Studying of a possible role of interstitial fibrosis in remodeling of myocardium. Material and methods. For the purpose of estimation of fibrosis, depending on degree of dilatation of the left ventricle there has been carried out examination ...
D. M. Ahmedova, B. G. Hojakuliyev
doaj   +1 more source

Cardiac Manifestations of Adrenal Insufficiency

Reviews in Cardiovascular Medicine, 2016
It is estimated that the prevalence of primary adrenal insufficiency (Addison disease) is 1 in 10,000 people. There are multiple case reports and several studies that suggest a correlation between Addison disease and abnormalities of cardiac function. The pathophysiology of cardiac abnormalities in this condition is incompletely understood. This review
Matthew M, Schumaecker, Timothy R, Larsen, David C, Sane   +2 more
openaire   +2 more sources

Repair Techniques for Mitral Valve Insufficiency in Children

, 2018
Congenital mitral valve (MV) dysplasia is a relatively rare and highly complex cardiac disease. We sought to provide a comprehensive analysis of the current surgical techniques for treating mitral valve insufficiency and the results of mitral valve ...
ZANOTTO, LORENZA, Vida, Vladimiro L., Padalino, Massimo A., Massimo A. Padalino, Carrozzini, Massimiliano, Stellin, Giovanni, Lorenza Zanotto, Massimiliano Carrozzini, Giovanni Stellin, Vladimiro L. Vida   +9 more
core   +1 more source

APOPTOSIS AND CHRONIC CARDIAC INSUFFICIENCY

Педиатрическая фармакология, 2009
Research into molecular apoptosis mechanisms in patients with cardio-vascular diseases is one of the pressing issues in modern medicine. Many mechanisms of this phenomenon still remain unexamined, the role of inductors and regulators in cardiomyocyte ...
A.G. Gasanov
doaj   +2 more sources

N-TERMINAL PRO-BRAIN NATRIURETIC PEPTIDE IN DIAGNOSTICS OF NON-COMPACTED MYOCARDIUM IN CHILDREN

Педиатрическая фармакология, 2012
Non-compacted myocardium is a rare congenital cardiomyopathy. Due to the lack of uniform criteria, diagnostics of this condition is complicated presently, which results in over-diagnosing.
E. N. Arkhipova, I. V. Sil’nova, E. N. Basargina, I. V. Dvoryakovskii, A. B. Sugak, N. A. Mayanskii, M. K. Umarova   +6 more
doaj   +1 more source

Biodegradable Conductors for Implantable and Wearable Transient Bioelectronics

Advanced Functional Materials, EarlyView.
Biodegradable conductors are essential building blocks for transient bioelectronics, enabling temporary sensing, stimulation, and energy transfer while eliminating the need for device retrieval. This review summarizes biodegradable metals, conducting polymers, ionic conductors, and conductive composites, highlighting degradation mechanisms, material ...
Yicheng Zhu, Yijun Liu, Naoji Matsuhisa
wiley   +1 more source

Microgels Enable iPSCs to Assemble, Expand, and Differentiate Into Organoids—From Sizable to High‐Throughput

Advanced Materials, EarlyView.
A chemically defined PEG‐based microgel platform enables scalable, reproducible production of three‐dimensional microgel‐iPSC constructs in multiple sizes. The system is compatible with high‐throughput automation and supports human iPSC expansion and differentiation within a single construct, including directed differentiation into cardiac organoids ...
Laura Klasen, Matthias Mork, Ramin Nasehi, Vasudha Turuvekere Krishnamurthy, Kira Zeevaert, Aaron Babendreyer, Jacopo Di Russo, Wolfgang Wagner, Laura De Laporte   +8 more
wiley   +1 more source

NMN improves cardiac function in SIRT3 knockout mice via the SIRT1/PGC-1α pathway

Scientific Reports
SIRT3 knockout mice develop cardiac insufficiency due to decreased mitochondrial function. However, upregulation of the NAD+/NADH ratio can compensate for SIRT3 deficiency through the SIRT1/PGC-1α pathway, thereby improving mitochondrial function.
Xiyao Zhao, Mengrui He, Lina He, Ruijie Han, Yanan Liu   +4 more
doaj   +1 more source

Proteasome functional insufficiency in cardiac pathogenesis

, 2011
The ubiquitin-proteasome system (UPS) is responsible for the degradation of most cellular proteins. Alterations in cardiac UPS, including changes in the degradation of regulatory proteins and proteasome functional insufficiency, are observed in many ...
Huabo Su, Jie Li, Hanqiao Zheng, Xuejun Wang, Saul R. Powell   +4 more
core   +1 more source