Results 71 to 80 of about 93,083 (312)

From Millimeters to Micrometers; Re-introducing Myocytes in Models of Cardiac Electrophysiology

Frontiers in Physiology, 2021
Computational modeling has contributed significantly to present understanding of cardiac electrophysiology including cardiac conduction, excitation-contraction coupling, and the effects and side-effects of drugs.
Karoline Horgmo Jæger, Andrew G. Edwards, Wayne R. Giles, Wayne R. Giles, Aslak Tveito   +4 more
doaj   +1 more source

Mitochondria‐endoplasmic reticulum organelle glue as maturation promoter for origination/dimensional dual‐cross cardiomyocytes

BMEMat, EarlyView.
Mitochondria‐endoplasmic reticulum contact sites (MERCS) are areas where the mitochondria and endoplasmic reticulum closely interact. In this study, we utilize synthetic organelle glues to artificially engineer MERCS for regulating cardiomyocyte development, through which the immature and chemo‐plasticity issues of undifferentiated cells are addressed.
Wei Tang, Hao Sun, Chenqi Duan, Jiajia Chang, Yuxing Wang, Ming Zhao, Huiyue Zhao, Shan Lu, Yang Yang, Da Huo   +9 more
wiley   +1 more source

Oxidative Stress-Responsive Apoptosis Inducing Protein (ORAIP) Plays a Critical Role in High Glucose-Induced Apoptosis in Rat Cardiac Myocytes and Murine Pancreatic β-Cells

Cells, 2017
We previously identified a novel apoptosis-inducing humoral factor in the conditioned medium of hypoxic/reoxygenated-cardiac myocytes. We named this novel post-translationally-modified secreted-form of eukaryotic translation initiation factor 5A ...
Takako Yao, Tsutomu Fujimura, Kimie Murayama, Ko Okumura, Yoshinori Seko   +4 more
doaj   +1 more source

A protocol for rapid and parallel isolation of myocytes and non-myocytes from multiple mouse hearts

STAR Protocols, 2021
Summary: This protocol features parallel isolation of myocytes and non-myocytes from murine hearts. It was designed with considerations for (1) time required to extract cardiac cells, (2) cell viability, and (3) protocol scalability.
Gabriella E. Farrugia, Micheal A. McLellan, Kate L. Weeks, Aya Matsumoto, Charles D. Cohen, Crisdion Krstevski, Taylah L. Gaynor, Adam C. Parslow, Julie R. McMullen, Alexander R. Pinto   +9 more
doaj   +1 more source

Acidosis in models of cardiac ventricular myocytes [PDF]

Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, 2006
The effects of acidosis on cardiac electrophysiology and excitation–contraction coupling have been studied extensively. Acidosis decreases the strength of contraction and leads to altered calcium transients as a net result of complex interactions between protons and a variety of intracellular processes. The relative contributions of each of the changes
Crampin, E.J., Smith, N.P., Langham, A.E., Clayton, R.H., Orchard, C.H.   +4 more
openaire   +4 more sources

The contribution of ionic currents to changes in refractoriness of human atrial myocytes associated with chronic atrial fibrillation [PDF]

, 2001
<b>Objective:</b> To investigate changes in human atrial single cell functional electrophysiological properties associated with chronic atrial fibrillation (AF), and the contribution to these of accompanying ion current changes.
K Shivkumar, Kane, K.A., Kane, Kathleen, Rankin, A.C., A Workman, Workman, A.J.   +5 more
core   +1 more source

Clinical Anatomy of the Left and Right Atrial Appendages in Humans: Comparative and Developmental Perspective

Clinical Anatomy, EarlyView.
ABSTRACT Human atrial chambers derive from distinct embryonic anlagens, the original embryonic atria gradually transforming into the so‐called auricles, or atrial appendages. This study quantifies macroscopic variations in pectinate muscle architecture in human atrial appendages and evaluates their visualization using clinical imaging modalities.
Markéta Lexová, Caroline Neradilová, Jan Kovanda, Jan Burkert, Jiří Beneš Jr., Martin Bartos, Theodor Adla, Vojtech Melenovsky, Alena Kvasilova, Ondrej Fabian, Ondrej Naňka, David Sedmera   +11 more
wiley   +1 more source

A novel method of cultivating cardiac myocytes in agarose microchamber chips for studying cell synchronization

Journal of Nanobiotechnology, 2004
We have developed a new method that enables agar microstructures to be used to cultivate cardiac myocyte cells in a manner that allows their connection patterns to be controlled. Non-contact three-dimensional photo-thermal etching with a 1064-nm infrared
Yasuda Kenji, Kaneko Tomoyuki, Kojima Kensuke   +2 more
doaj   +1 more source

HL-1 cells express an inwardly rectifying K+ current activated via muscarinic receptors comparable to that in mouse atrial myocytes

, 2010
An inwardly rectifying K^+ current is present in atrial cardiac myocytes that is activated by acetylcholine (I_{KACh}). Physiologically, activation of the current in the SA node is important in slowing the heart rate with increased parasympathetic tone ...
Muriel Nobles, Sonia Sebastian, Tinker, A., Andrew Tinker, Nobles, M., Sebastian, S., Nobles, Muriel   +6 more
core   +1 more source

A Compartmentalized Mathematical Models of Normal and Failing Mouse Cardiac Myocytes

, 2023
Atrial fibrillations and heart failure are among the leading cardiovascular diseases in the world. Understanding the development and progression of these diseases requires a thorough knowledge of the electrophysiological mechanisms in a healthy and ...
Asfaw, Tesfaye Negash
core   +1 more source