Results 1 to 10 of about 81,648 (268)

Down-regulation of replication factor C-40 (RFC40) causes chromosomal missegregation in neonatal and hypertrophic adult rat cardiac myocytes. [PDF]

PLoS ONE, 2012
BACKGROUND: Adult mammalian cardiac myocytes are generally assumed to be terminally differentiated; nonetheless, a small fraction of cardiac myocytes have been shown to replicate during ventricular remodeling.
Hirotaka Ata, Deepa Shrestha, Masahiko Oka, Rikuo Ochi, Chian Ju Jong, Sarah Gebb, John Benjamin, Stephen Schaffer, Holly H Hobart, James Downey, Ivan McMurtry, Rakhee Gupte   +11 more
doaj   +1 more source

Innate immune signaling in hearts and buccal mucosa cells of patients with arrhythmogenic cardiomyopathy

Heart Rhythm O2, 2023
Background: Nuclear factor κB (NF-κB) signaling in cardiac myocytes causes disease in a mouse model of arrhythmogenic cardiomyopathy (ACM) by mobilizing CCR2-expressing macrophages that promote myocardial injury and arrhythmias.
Carlos Bueno-Beti, PhD, Alessandro Tafuni, MD, Stephen P. Chelko, PhD, FHRS, Mary N. Sheppard, MD, Ella Field, MSc, Jennifer Tollit, MSc, Imogen K. Heenan, BSc, Annabelle Barnes, BSc, Matthew R. Taylor, MD, PhD, Luisa Mestroni, MD, Juan Pablo Kaski, MD, Jeffrey E. Saffitz, MD, PhD, FHRS, Angeliki Asimaki, PhD   +12 more
doaj   +1 more source

Myocardial Mitochondrial DNA Drives Macrophage Inflammatory Response through STING Signaling in Coxsackievirus B3-Induced Viral Myocarditis

Cells, 2023
Coxsackievirus B3 (CVB3), a single-stranded positive RNA virus, primarily infects cardiac myocytes and is a major causative pathogen for viral myocarditis (VMC), driving cardiac inflammation and organ dysfunction.
Andong Qin, Zhenke Wen, Sidong Xiong
doaj   +1 more source

A Comorbidity Model of Myocardial Ischemia/Reperfusion Injury and Hypercholesterolemia in Rat Cardiac Myocyte Cultures

Frontiers in Physiology, 2020
IntroductionThe use of comorbidity models is crucial in cardioprotective drug development. Hypercholesterolemia causes endothelial and myocardial dysfunction, as well as aggravates ischemia/reperfusion (I/R)-induced myocardial injury.
András Makkos, Ágnes Szántai, János Pálóczi, Judit Pipis, Bernadett Kiss, Bernadett Kiss, Paola Poggi, Péter Ferdinandy, Péter Ferdinandy, Péter Ferdinandy, Alexandros Chatgilialoglu, Anikó Görbe, Anikó Görbe, Anikó Görbe   +13 more
doaj   +1 more source

High-Sensitive Cardiospecific Troponins: The Role of Gender-Specific Concentration in the Diagnosis of Acute Coronary Syndrome (Descriptive Review)

Reviews in Cardiovascular Medicine, 2023
Cardiospecific troponins are specifically localized in the troponin-tropomyosin complex and in the cytoplasm of cardiac myocytes. Cardiospecific troponin molecules are released from cardiac myocytes upon their death (irreversible damage in acute coronary
Aleksey Chaulin
doaj   +1 more source

Comprehensive Expression Analysis of Cardiac Fibroblast Growth Factor 23 in Health and Pressure-induced Cardiac Hypertrophy

Frontiers in Cell and Developmental Biology, 2022
Enhanced fibroblast growth factor 23 (FGF23) is associated with left ventricular hypertrophy (LVH) in patients with chronic kidney and heart disease. Experimentally, FGF23 directly induces cardiac hypertrophy and vice versa cardiac hypertrophy stimulates
Fiona Eitner, Beatrice Richter, Saskia Schwänen, Malgorzata Szaroszyk, Isabel Vogt, Andrea Grund, Thomas Thum, Joerg Heineke, Joerg Heineke, Dieter Haffner, Maren Leifheit-Nestler   +10 more
doaj   +1 more source

Paracrine Effects of FGF23 on the Heart

Frontiers in Endocrinology, 2018
Fibroblast growth factor (FGF) 23 is a phosphaturic hormone primarily secreted by osteocytes to maintain phosphate and mineral homeostasis. In patients with and without chronic kidney disease, enhanced circulating FGF23 levels associate with pathologic ...
Maren Leifheit-Nestler, Dieter Haffner
doaj   +1 more source

Silibinin Protects Against Isoproterenol-Induced Rat Cardiac Myocyte Injury Through Mitochondrial Pathway After Up-regulation of SIRT1

Journal of Pharmacological Sciences, 2006
Terminally differentiated adult injured cardiac myocytes have been used for various animal models of heart failure. It has recently been shown that isoproterenol induces injury in rat neonatal cardiac myocytes via a β-adrenergic pathway, suggesting that ...
Bei Zhou, Li-Jun Wu, Lin-Hao Li, Shin-ichi Tashiro, Satoshi Onodera, Fumiaki Uchiumi, Takashi Ikejima   +6 more
doaj   +1 more source

C-reactive protein inhibits survivin expression via Akt/mTOR pathway downregulation by PTEN expression in cardiac myocytes. [PDF]

PLoS ONE, 2014
C-reactive protein (CRP) is one of the most important biomarkers for arteriosclerosis and cardiovascular disease. Recent studies have shown that CRP affects cell cycle and inflammatory process in cardiac myocytes.
Beom Seob Lee, Soo Hyuk Kim, Jaewon Oh, Taewon Jin, Eun Young Choi, Sungha Park, Sang-Hak Lee, Ji Hyung Chung, Seok-Min Kang   +8 more
doaj   +1 more source

Modulations of Cardiac Functions and Pathogenesis by Reactive Oxygen Species and Natural Antioxidants

Antioxidants, 2021
Homeostasis in the level of reactive oxygen species (ROS) in cardiac myocytes plays a critical role in regulating their physiological functions. Disturbance of balance between generation and removal of ROS is a major cause of cardiac myocyte remodeling ...
Sun-Hee Woo, Joon-Chul Kim, Nipa Eslenur, Tran Nguyet Trinh, Long Nguyen Hoàng Do   +4 more
doaj   +1 more source